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Abemaciclib-fulvestrant improves OS in HR+, HER2- breast cancer

Roshini Claire Anthony, 14 hours ago

A combination of the CDK 4/6 inhibitor abemaciclib with fulvestrant improved overall survival (OS) in patients with HR+, HER2- advanced breast cancer (ABC), with a trend toward improved outcomes in patients with poor prognosis, according to results of the phase III MONARCH 2* trial presented at ESMO 2019.

Air pollution ruins health in the very young

Tristan Manalac, 3 days ago

Exposure to air pollution increases the risk of death in infants and impairs lung function in young children, according to two studies presented at the recently concluded International Congress of the European Respiratory Society (ERS 2019).

First-line olaparib maintenance improves PFS in advanced ovarian cancer

Roshini Claire Anthony, 4 days ago

A maintenance regimen comprising olaparib and bevacizumab led to greater progression-free survival (PFS) in patients newly diagnosed with advanced ovarian cancer, results of the phase III PAOLA-1/ENGOT-ov25* study showed.

Bisphenol A exposure during pregnancy tied to respiratory problems in offspring

Tristan Manalac, 4 days ago

Babies born to mothers exposed to high levels of bisphenol A during pregnancy are at a greater risk of wheezing and poor lung function, according to a new study presented at the recently concluded International Congress of the European Respiratory Society (ERS 2019).

Veliparib regimen boosts PFS in women with advanced ovarian cancer

Elvira Manzano, 03 Oct 2019

Veliparib added onto frontline chemotherapy followed by veliparib maintenance monotherapy (veliparib throughout) significantly prolonged progression-free survival (PFS) in women with newly diagnosed high-grade serous ovarian carcinoma, the phase III placebo-controlled VELIA/GOG-3005 trial has shown.

Gestational diabetes risk elevated following ART

Roshini Claire Anthony, 30 Sep 2019

Women who conceive singleton pregnancies following assisted reproductive technology (ART) may have a higher risk of developing gestational diabetes than those who conceive spontaneously, according to results of a systematic review and meta-analysis presented at EASD 2019.

The Evolving Role of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 in Women’s Urogenital Health

12 Jun 2019

Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.

Immunization protects children from vaccine-preventable diseases

21 Mar 2018

During the Kuala Lumpur International Neonatology Conference held in conjunction with the World Prematurity Day 2017, Dato Dr Musa Mohd Nordin spoke on the importance of immunizing children with the diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. He highlighted the role of Hexaxim® as a fully liquid, ready-to-use, 6-in-1 (including hepatitis B) vaccine for the primary and booster vaccinations of infants and toddlers. Meanwhile, Dr Yong Junina Fadzil discussed the benefits of quadrivalent influenza vaccines (QIVs) in providing children with broader protection against influenza B viruses.

Bye-bye vaginal infection, hello vaginal flora!

22 Jan 2018

The human body is home to an estimated 100 trillion microbial cells and a quadrillion viruses, which are collectively known as the human microbiota. Recently, the human microbiota has gained the attention of the scientific fraternity for its roles in health and diseases, with some quarters referring to it as the 'forgotten organ'. Imbalances in the usual composition of commensal or symbiotic species in a localized area of the body is known as microbial shift or dysbiosis, and this condition may result in infections caused by opportunistic pathogens, thereby impacting the natural defence mechanism of the human body.

Higher obstetric complications, twin births with delayed embryo transfer during IVF

Elvira Manzano, 01 Aug 2019

Delaying the transfer of embryo until the blastocyst stage during in-vitro fertilization (IVF) increased obstetric complications and twin births in a Nordic study. This finding is particularly important as there’s a spike in assisted reproduction technology (ART) treatments being performed with blastocyst transfer (BT) in recent years, according to the investigators.

No benefit of ICSI over IVF in non-male factor infertility

Roshini Claire Anthony, 25 Jul 2019

Patients undergoing assisted reproduction for non-male factor infertility do not derive greater benefit from intracytoplasmic sperm injection (ICSI) over in vitro fertilization (IVF), according to a study presented at ESHRE 2019.

Frozen, fresh embryo transfers yield similar growth outcomes

Elaine Soliven, 23 Jul 2019

Children who were born after frozen embryo transfer (FET) showed comparable growth outcomes during their first 5 years of life as those who were born after fresh ET, according to a study presented at ESHRE 2019.

Long-term sperm cryopreservation does not affect pregnancy success

Roshini Claire Anthony, 22 Jul 2019

Likelihood of pregnancy following artificial insemination by donor (AID) or in vitro fertilization (IVF) was not negatively affected by using sperm that had been cryopreserved for up to 15 years, according to a study from China.

Immediate frozen embryo transfer improves pregnancy, live birth rates

Elaine Soliven, 19 Jul 2019

Women who underwent immediate frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) cycle were more likely to have ongoing pregnancy and live birth compared with those who underwent delayed FET, according to a study presented at ESHRE 2019.

New study questions widespread use of freeze-all strategy in IVF

Pearl Toh, 18 Jul 2019

The increasingly adopted strategy to freeze all IVF* embryos for transfer in a later cycle offers no improvement in ongoing pregnancy rates over the conventional strategy of fresh embryo transfer among normo-ovulatory women, thus calling into question a general freeze-all strategy in a growing number of clinics.

Increasing paternal age may reduce IVF/ICSI success rate

Roshini Claire Anthony, 18 Jul 2019

The likelihood of pregnancy following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is significantly reduced when male partners are aged 51 years and older, according to a retrospective study from the UK.

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