Obstetrics & Gynaecology

Top Medical News
Tranexamic acid does not prevent haemorrhage-related events in Caesarean section

Among women with multiple pregnancies, prophylactic treatment with tranexamic acid does not appear to reduce the incidence of blood loss-related events following caesarean delivery, a study has shown.

Maintenance niraparib a boon in advanced ovarian cancer
Jairia Dela Cruz, 2 days ago

Use of niraparib in the maintenance setting appears to minimize the risk of progression in advanced ovarian cancer patients, with surgical timing having little to no effect on the drug’s efficacy, as shown in a post hoc analysis of the phase III PRIMA/ENGOT-OV26/GOG-3012 study.

Premature menopause poses increased mortality risk
3 days ago
While affecting only a small group of women, premature ovarian insufficiency appears to have a negative effect on mortality, according to a study.
Antibiotic use for chronic endometritis poses risk of miscarriage after ART
6 days ago
The use of antibiotic therapy to resolve chronic endometritis can put women undergoing assisted reproductive treatment (ART) at heightened risk of pregnancy loss, according to a study.
Occupational lifting, pushing put women at risk of pelvic organ prolapse
19 Jun 2022
Physically demanding jobs may be hazardous to women, with a recent study reporting that occupational load-bearing contributes to an increase in the risk of developing symptomatic pelvic organ prolapse during midlife.
Expectant moms with low vitamin D levels at risk of miscarriage
Jairia Dela Cruz, 16 Jun 2022
Pregnant women with vitamin D deficiency run the risk of losing their foetuses in the womb, according to a meta-analysis.
How effective are contraceptive counseling, provision interventions for women?
16 Jun 2022
Contraceptive counseling and provision of services beyond usual care are both effective at improving contraceptive use without increasing sexually transmitted infections (STIs) or reducing condom use, results of a systematic review and meta-analysis have shown.
Special Reports
Management of recurrent implantation failure during the COVID-19 pandemic
Dr. Ameet Patki, Dr. Prakash Mayandi, 22 Mar 2022
Recurrent implantation failure (RIF) refers to the failure to achieve a clinical pregnancy after three in vitro fertilization (IVF) attempts with at least four good-quality embryos. RIF leaves couples frustrated and desperate for answers and is challenging for clinicians to handle, compounded by the impact of the COVID-19 pandemic restrictions. Two experts, Dr Ameet Patki, Medical Director of Fertility Associates Mumbai and Hon Assoc Prof at KJ Somaiya Medical College & Hospital, India, and Dr Prakash Mayandi, Metro IVF Fertility Centre, Kuala Lumpur, Malaysia, weigh in with their views on managing RIF during the COVID-19 pandemic.
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01 Dec 2021
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The changing treatment landscape for premenopausal women with advanced breast cancer: Focus on ribociclib
Dr. Wong Seng Weng, Dr. Lee Guek Eng, 19 Mar 2021
In Singapore, advanced breast cancer (aBC) is the leading cause of cancer death in women 30–49 years of age. For premenopausal women diagnosed with hormone receptor (HR)-positive, HER2-negative BC, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors provide new hope. Currently, ribociclib is the only CDK4/6 inhibitor studied in the first-line setting for premenopausal women with HR+/HER2- aBC, in the phase III MONALEESA-7 trial. Two experts, Dr Wong Seng Weng, Medical Director & Consultant Medical Oncologist at The Cancer Centre, Paragon Medical & Mount Elizabeth Novena Specialist Centre, and Dr Lee Guek Eng, Senior Consultant & Specialist in Medical Oncology at Icon Cancer Centre and Program Director of the Young Women Cancer Program, weigh in with their views on managing premenopausal women with aBC.
Acute diarrhoea is the second leading cause of death
in children aged younger than 5 years, accounting for
approximately 1.
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.
Expert consensus: Patient profile should guide antihistamine choice in primary care setting
10 Dec 2019
Oral H1-antihistamines are the initial treatment of choice for allergic rhinitis (AR) and chronic urticaria in the primary care setting. However, in a diverse population of patients with AR and urticaria, primary care physicians are faced with the challenge of prescribing the best therapy amid a wide armamentarium of antihistamines available.
Gangliosides and cognition: An appraisal of the evidence
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

SNPs likely to improve breast cancer risk prediction
Dr Joslyn Ngu, 04 Dec 2017

Incorporating polygenic risk scores based on 18 SNPs (single nucleotide polymorphisms) into risk stratification for breast cancer will improve screening results, says an expert.

Conference Reports
Postpartum depression: Another outcome of the COVID-19 pandemic?
Roshini Claire Anthony, 08 Jun 2022

Several studies presented at ACOG 2022 have raised the question as to whether postpartum depression (PPD) is one of the mental health outcomes of the COVID-19 pandemic.

Linzagolix benefits Hb levels, mood, QoL
Roshini Claire Anthony, 26 May 2022

The use of the oral GnRH antagonist linzagolix in patients with heavy menstrual bleeding (HMB) due to uterine fibroids induced multiple benefits including improved haemoglobin (Hb) levels, health-related quality of life (HRQoL), and mood, analysis of the PRIMROSE 1 and 2 trials showed.

Fezolinetant reduces hot flashes in menopausal women
Elaine Soliven, 21 May 2022
Treatment with fezolinetant significantly reduced the frequency and severity of vasomotor symptoms (VMS), particularly hot flashes, in women during their menopausal phase, according to the SKYLIGHT 1* trial presented at ACOG 2022.
Once-daily, low-dose elagolix reduces HMB in premenopausal women with uterine fibroids
Elaine Soliven, 20 May 2022
Once-daily (QD) administration of low-dose elagolix 150 mg led to significantly reduced heavy menstrual bleeding (HMB) in premenopausal women with uterine fibroids, according to a study presented at ACOG 2022.
Relugolix combo improves uterine fibroid symptoms regardless of fibroid location
Stephen Padilla, 17 May 2022
Combination therapy with relugolix (once daily relugolix 40 mg, estradiol 1 mg, norethindrone acetate 0.5 mg) leads to improvement in heavy menstrual bleeding (HMB) and in other uterine fibroid (UF)-related symptoms independent of the location of the largest fibroid, results of a recent study have shown.
Pelvic floor dysfunction in women warrants further attention
Audrey Abella, 17 May 2022
There appears to be a dearth of evidence on the management of nonrelaxing pelvic floor dysfunction (PFD), a debilitating condition characterized by tension of the pelvic floor muscles that frequently leads to pelvic pain, according to data presented at ACOG 2022.
Levonorgestrel IUD  staves off heavy menses in obese nulliparous women
Elvira Manzano, 17 May 2022
The use of an intrauterine device (IUD) containing levonorgestrel 52 mg cuts heavy menses in obese nulliparous women in a phase III study.