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Asthma attack during pregnancy may foretell adverse outcomes for maternal and child health

Pearl Toh, Yesterday

Children of women who had asthma exacerbations during pregnancy were more likely have respiratory disorders such as asthma and pneumonia than those whose mothers did not — suggesting that the effects of asthma exacerbations during pregnancy may transcend generations, a study finds. This was in addition to having an increased risk of adverse pregnancy and perinatal outcomes.

No link between talc powder and ovarian cancer risk in large study

Pearl Toh, 10 Jan 2020

There was no evidence that the use of talc powder in the genital area was associated with an increased risk of ovarian cancer, a large pooled analysis of four prospective cohort studies shows.

Ovarian cancer rates in Singapore doubled over past 4 decades

Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Sleeping poorly in older pregnant women may be bad for babies

Jairia Dela Cruz, 10 Jan 2020

Poor sleep quality in pregnant women with advanced maternal age (AMA) may adversely affect neonatal health outcomes, increasing the risk of shorter birth length and the likelihood of admission to a special care nursery or neonatal intensive care unit (NICU), as reported in a recent study.

Persistent reduction of breast cancer risk after anastrozole cessation

Roshini Claire Anthony, 09 Jan 2020

The reduced incidence of breast cancer with 5-year prophylaxis with the aromatase inhibitor anastrozole among women at high risk of the disease persists even after anastrozole cessation, suggests long-term results of the IBIS-II* trial presented at SABCS 2019.

Tucatinib may prolong survival in heavily pretreated HER2+ metastatic breast cancer

Roshini Claire Anthony, 08 Jan 2020

The addition of tucatinib to a trastuzumab-capecitabine regimen improved progression-free survival (PFS) in patients with HER2+ metastatic breast cancer (MBC) previously treated with multiple HER2-targeted agents, according to the HER2CLIMB* study presented at SABCS** 2019. Additionally, this improved PFS was also noted in patients with brain metastases.

Pre-pregnancy acetaminophen use tied to increased adverse birth outcomes risk

Elaine Soliven, 08 Jan 2020

The use of acetaminophen 3 months prior to pregnancy was associated with an increased risk of adverse birth outcomes, such as low birth weight (LBW), preterm birth (PTB), and small-for-gestational-age (SGA), according to a recent study.

Expert consensus: Patient profile should guide antihistamine choice in primary care setting

10 Dec 2019

Oral H₁-antihistamines are the initial treatment of choice for allergic rhinitis (AR) and chronic urticaria in the primary care setting. However, in a diverse population of patients with AR and urticaria, primary care physicians are faced with the challenge of prescribing the best therapy amid a wide armamentarium of antihistamines available.

The Evolving Role of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 in Women’s Urogenital Health

12 Jun 2019

Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.

Immunization protects children from vaccine-preventable diseases

21 Mar 2018

During the Kuala Lumpur International Neonatology Conference held in conjunction with the World Prematurity Day 2017, Dato Dr Musa Mohd Nordin spoke on the importance of immunizing children with the diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. He highlighted the role of Hexaxim® as a fully liquid, ready-to-use, 6-in-1 (including hepatitis B) vaccine for the primary and booster vaccinations of infants and toddlers. Meanwhile, Dr Yong Junina Fadzil discussed the benefits of quadrivalent influenza vaccines (QIVs) in providing children with broader protection against influenza B viruses.

Bye-bye vaginal infection, hello vaginal flora!

22 Jan 2018

The human body is home to an estimated 100 trillion microbial cells and a quadrillion viruses, which are collectively known as the human microbiota. Recently, the human microbiota has gained the attention of the scientific fraternity for its roles in health and diseases, with some quarters referring to it as the 'forgotten organ'. Imbalances in the usual composition of commensal or symbiotic species in a localized area of the body is known as microbial shift or dysbiosis, and this condition may result in infections caused by opportunistic pathogens, thereby impacting the natural defence mechanism of the human body.

Persistent reduction of breast cancer risk after anastrozole cessation

Roshini Claire Anthony, 09 Jan 2020

Tucatinib may prolong survival in heavily pretreated HER2+ metastatic breast cancer

Roshini Claire Anthony, 08 Jan 2020

Higher obstetric complications, twin births with delayed embryo transfer during IVF

Elvira Manzano, 01 Aug 2019

Delaying the transfer of embryo until the blastocyst stage during in-vitro fertilization (IVF) increased obstetric complications and twin births in a Nordic study. This finding is particularly important as there’s a spike in assisted reproduction technology (ART) treatments being performed with blastocyst transfer (BT) in recent years, according to the investigators.

No benefit of ICSI over IVF in non-male factor infertility

Roshini Claire Anthony, 25 Jul 2019

Patients undergoing assisted reproduction for non-male factor infertility do not derive greater benefit from intracytoplasmic sperm injection (ICSI) over in vitro fertilization (IVF), according to a study presented at ESHRE 2019.

Frozen, fresh embryo transfers yield similar growth outcomes

Elaine Soliven, 23 Jul 2019

Children who were born after frozen embryo transfer (FET) showed comparable growth outcomes during their first 5 years of life as those who were born after fresh ET, according to a study presented at ESHRE 2019.

Long-term sperm cryopreservation does not affect pregnancy success

Roshini Claire Anthony, 22 Jul 2019

Likelihood of pregnancy following artificial insemination by donor (AID) or in vitro fertilization (IVF) was not negatively affected by using sperm that had been cryopreserved for up to 15 years, according to a study from China.

Immediate frozen embryo transfer improves pregnancy, live birth rates

Elaine Soliven, 19 Jul 2019

Women who underwent immediate frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) cycle were more likely to have ongoing pregnancy and live birth compared with those who underwent delayed FET, according to a study presented at ESHRE 2019.

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