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Managing endometriosis in primary care

Yesterday

Endometriosis is a chronic gynaecologic condition affecting up to one in every 10 women. KK Women’s and Children’s Hospital (KKH) in Singapore treats approximately 1,200 women with endometriosis-related problems every year. Audrey Abella speaks with Dr Wei-Wei Wee-Stekly, consultant at the Minimally Invasive Surgery Unit at KKH, on how this condition can be appropriately addressed in the primary care setting.

Ribociclib add-on to NSAI + goserelin prolongs PFS in HR+, HER2- advanced breast cancer

Elaine Soliven, 03 Dec 2018

Adding ribociclib, a CDK*4/6 inhibitor, to NSAI** and goserelin improves progression-free survival (PFS) in premenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC), according to the MONALEESA-7*** study presented at ESMO Asia 2018.

Pregnancy outcomes favourable for women with idiopathic noncirrhotic portal hypertension

25 Nov 2018

Despite condition-related complications, pregnancy in women with idiopathic noncirrhotic portal hypertension results in favourable foetal outcomes in a majority of cases reaching 20 weeks of gestation, reports a new study.

Immunization protects children from vaccine-preventable diseases

21 Mar 2018

During the Kuala Lumpur International Neonatology Conference held in conjunction with the World Prematurity Day 2017, Dato Dr Musa Mohd Nordin spoke on the importance of immunizing children with the diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. He highlighted the role of Hexaxim® as a fully liquid, ready-to-use, 6-in-1 (including hepatitis B) vaccine for the primary and booster vaccinations of infants and toddlers. Meanwhile, Dr Yong Junina Fadzil discussed the benefits of quadrivalent influenza vaccines (QIVs) in providing children with broader protection against influenza B viruses.

Bye-bye vaginal infection, hello vaginal flora!

22 Jan 2018

The human body is home to an estimated 100 trillion microbial cells and a quadrillion viruses, which are collectively known as the human microbiota. Recently, the human microbiota has gained the attention of the scientific fraternity for its roles in health and diseases, with some quarters referring to it as the 'forgotten organ'. Imbalances in the usual composition of commensal or symbiotic species in a localized area of the body is known as microbial shift or dysbiosis, and this condition may result in infections caused by opportunistic pathogens, thereby impacting the natural defence mechanism of the human body.

IMpassion 130 heralds in a new era for immunotherapy in breast cancer

Pearl Toh, 01 Nov 2018

Treatment with the PD-L1 inhibitor atezolizumab on top of standard chemotherapy with nab-paclitaxel significantly improves progression-free survival (PFS) in triple-negative breast cancer (TNBC) compared with nab-paclitaxel alone, top-line results from the IMpassion* 130 trial reveal. In particular, median overall survival (OS) was 10 months longer with atezolizumab among PD-L1-positive (PD-L1+) patients in an interim analysis.

Combo therapy with zoledronic acid improves DFS in premenopausal HR+ early BC

Pearl Toh, 25 Oct 2018

Adding the combination therapy of zoledronic acid + letrozole to triptorelin as adjuvant treatment for hormone receptor positive (HR+) early breast cancer in premenopausal women significantly improves disease-free survival (DFS) compared with the combination of tamoxifen and triptorelin, according to the HOBOE-2* study presented at ESMO 2018.

First-in-class CDK 4/6 inhibitor improves overall survival in advanced breast cancer patients

Dr. Joseph Delano Fule Robles, 22 Oct 2018

Final analysis of results from the PALOMA-3 study showed improvement in overall survival (OS) with addition of cyclin-dependent kinase (CDK) 4/6 inhibitor palbociclib to fulvestrant in hormone receptor−positive, HER2-negative advanced breast cancer that has relapsed or progressed on hormonal therapy.

AMH may not predict oocyte yield in breast cancer patients

Pearl Toh, 29 Aug 2018

Levels of anti-Müllerian hormone (AMH) may not correlate with ovarian reserve in patients with breast cancer, suggests a study presented at ESHRE 2018, thus raising questions on the utility of AMH testing before hormonal stimulation in fertility preservation for women with breast cancer.

Younger lymphoma patients may be less susceptible to chemo-induced ovarian toxicity

Pearl Toh, 27 Aug 2018

Chemotherapy may be less damaging to fertility of female lymphoma patients who are of a younger age than those who are older, even in the case of an alkylating regimen, suggests a study presented at ESHRE 2018.

Tubal flushing with oil-based contrast ups pregnancy success

Pearl Toh, 20 Aug 2018

Tubal flushing with oil-based contrast medium at hysterosalpingography (HSG) leads to a higher ongoing pregnancy rate beyond the previously reported results at 6 months, with significantly shorter time to ongoing pregnancy than flushing with water-based contrast, according to a study presented at ESHRE 2018.

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