nonalcoholic%20fatty%20liver%20disease
NONALCOHOLIC FATTY LIVER DISEASE

Nonalcoholic fatty liver disease is having excessive fat (in the form of triglycerides) accumulation not due to excessive alcohol consumption or other secondary causes.

It is considered as a hepatic manifestation of metabolic syndrome.

Progression of nonalcoholic fatty liver disease is variable.

Surgical Intervention

Bariatric Surgery
  • Alternative therapy in patients unresponsive to lifestyle changes and pharmacological therapy to reduce weight and metabolic complications as it has long-term stable results
  • It was shown in the surrogate markers that bariatric surgery is effective on NAFLD-associated liver injury and there is also initial evidence for improved necroinflammation and fibrosis
  • It is advised that surgery should be done before the patient becomes cirrhotic
Liver Transplantation
  • Accepted procedure in NASH patients with end-stage liver disease
  • It was found that overall survival after transplantation is approximately identical with patients who received liver transplants for hepatic failure caused by other liver diseases
  • Comorbid conditions limit eligibility for transplantation
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