nonalcoholic%20fatty%20liver%20disease
NONALCOHOLIC FATTY LIVER DISEASE

Nonalcoholic fatty liver disease is having excessive fat (in the form of triglycerides) accumulation not due to excessive alcohol consumption or other secondary causes.

It is considered as a hepatic manifestation of metabolic syndrome.

Progression of nonalcoholic fatty liver disease is variable.

Lifestyle Modification

  • The only effective treatment for nonalcoholic fatty liver (NAFL) is weight loss
    • It was found that a gradual weight loss of 5-10% has shown improvement in hepatic insulin resistance, liver histology & enzymes levels but not in fibrosis
  • Lifestyle modification overall goals are to reduce excess body weight through diet & exercise therapies for a period of 3-12 months
  • To improve NAFL/nonalcoholic steatohepatitis (NASH), it is recommended to prioritize the optimization of energy intake & restricting lipids in terms of the proportions of nutrient intake

Diet

  • It was found that moderate calorie-restricted diet with modified macronutrient composition produces better results in comparison with a very low-caloric diet
  • Avoid beverages & foods that contain fructose & trans-fat
  • Increasing intake of omega-3/omega-6 polyunsaturated fatty acids in diet is suggested

Alcohol intake

  • Keep alcohol intake below the risk threshold of 30 g for men & 20 g for women
  • Heavy alcohol intake is a risk factor for chronic liver disease & should be avoided by patients with NAFL & NASH

Coffee drinking

  • Found to have protective element in NAFLD & reduces histological severity & liver-related outcomes

Exercise/physical activity

  • Moderate intensity aerobic physical activities 150-200 minutes/week in 3-5 sessions is recommended
    • Has been shown to improve fatty changes in the liver even without accompanying reduced body weight
  • It was also found that resistance training is also effective as it promotes musculoskeletal fitness with effects on metabolic risk factors
  • Any increase on previous levels of physical activity is better than continuing inactivity
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.