Non-hodgkin's%20lymphoma News

News

Lenalidomide plus CHOP: Acceptable toxicity in elderly with angioimmunoblastic T-cell lymphoma

Christina Lau, 20181221084142

Lenalidomide, given for 14 days in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), has demonstrated acceptable toxicity in the REVAIL study in elderly patients with angioimmunoblastic T-cell lymphoma (AITL), with efficacy results similar to reports from previous studies.

Brentuximab vedotin + CHP doubles PFS over CHOP in CD30+ peripheral T-cell lymphoma

Roshini Claire Anthony, 20181211140309

The combination of brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A+CHP) more than doubled progression-free survival (PFS) as well as improved overall survival (OS) in patients with CD30-expressing peripheral T-cell lymphoma compared with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), according to results of the phase III ECHELON-2* trial.

VR-CAP trumps R-CHOP for front-line treatment of mantle cell lymphoma

Roshini Claire Anthony, 20181029140207

Adults newly diagnosed with mantle cell lymphoma who were unable to undergo bone marrow transplantation had longer overall survival (OS) following first-line treatment with VR-CAP* compared with R-CHOP**, according to final results of the phase III LYM-3002*** trial.

New treatment option now available for patients with HR+/HER2- aBC/MBC, PIK3CA mutations

31 Mar 2021

At the recent webinar entitled Pik Me Up: Mutation Matters, Consultant Medical Oncologist Dr Senthil Rajappa discussed the role of PI3Kα-specific inhibitor alpelisib (TREZILENT^®, Novartis) in managing patients with HR+/HER2- aBC/MBC and PIK3CA mutations while Senior Consultant Pathologist Professor Dr Pathmanathan Rajadurai explained the process of detecting PIK3CA mutations in patients.

Immunotherapy sparks hope for paediatric ALL

Audrey Abella, 14 Oct 2020

Despite a 90-percent cure rate after first treatment for children with acute lymphoblastic leukaemia (ALL), approximately 10–15 percent of patients with paediatric ALL will experience relapse. [Expert Rev Anticancer Ther 2017;17:725-736] A recent webinar on the current landscape of ALL highlighted the potential of immunotherapy for paediatric patients with relapsed or refractory ALL, thus providing hope for this high-risk patient group.

Relationship between tumour response to systemic therapy and overall survival in unresectable hepatocellular carcinoma

Dr Raghav Sundar, 09 Sep 2019

Overall survival (OS) is currently the primary criteria in assessing the efficacy of a cancer treatment. Dr Raghav Sundar, a consultant medical oncologist at the National University Hospital, Singapore, details the crucial role played by tumour response in evaluating treatment efficacy, with a focus on the multiple kinase inhibitor lenvatinib in the treatment of hepatocellular carcinoma (HCC).