Deep brain stimulation (DBS) of the ventral anterior limb of the internal capsule (vALIC) is well tolerated and effective for patients with treatment-refractory obsessive-compulsive disorder (OCD), a recent study has shown.
The anticonvulsant drugs levetiracetam, fosphenytoin and valproate all demonstrate efficacy for benzodiazepine-refractory convulsive status epilepticus, with each drug inducing seizure cessation and improving alertness in most patients and yielding similar safety outcomes, according to data from the Established Status Epilepticus Treatment Trial (ESETT).
In the treatment of paediatric patients with postdural puncture headache refractory to conservative therapies, the use of cosyntropin results in rapid pain relief, according to data from a retrospective analysis.
Higher intake of plant-based fat, in particular n-6 polyunsaturated fatty acids (PUFAs), in place of carbohydrate during midlife was associated with a reduced risk of cognitive impairment in Chinese adults in later life, according to the Singapore Chinese Health Study (SCHS).
Use of lacosamide therapy in the long-term management of adult patients with epilepsy is effective and well tolerated, yielding seizure freedom rates comparable to that achieved with controlled‐release carbamazepine (carbamazepine‐CR), as reported in a recent study.
Prior intake of direct oral anticoagulants (DOACs) bears no increased risk of symptomatic intracerebral haemorrhage in acute ischaemic stroke patients initiating treatment with intravenous thrombolysis (IVT), according to the results of a meta-analysis.
A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).