Several microRNAs (miRNAs) are differentially expressed in the brain, cerebrospinal fluid and blood in Alzheimer’s disease and may help improve early detection of the disease, reports a recent meta-analysis.
Screening for Alzheimer’s disease and related dementias (ADRD) in older adults does not improve health-related quality of life (HRQoL), though it also does not seem to cause additional harm, a recent study has found.
The presence of microembolic signals following successful endovascular treatment of anterior circulation occlusions has no bearing on clinical or radiological outcome, although it is a red flag for recurrence of embolic events within 90 days, a study has found.
Individuals exposed to elevated blood pressure (BP) levels from young adulthood to midlife are likely to have poor gait and cognitive performance in midlife, a study suggests. Cerebral white matter hyperintensity moderates the relationship of cumulative BP exposure with gait but not with cognitive function.
Administering cannabis via inhalation methods appears to cut the perceived severity of headache and migraine by about 50 percent, although the effect weakens over time and patients therefore use increasing doses, a study has reported. This suggests that tolerance to the effects of cannabis may develop with continued exposure.
A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).