Neurology

Long-term risk of anticoagulant-related bleeding high in patients with first unprovoked VTE

an hour ago

There appears to be substantial long-term risks and consequences of anticoagulant-related major bleeding in patients with a first unprovoked venous thromboembolism (VTE), suggests a recent study.

Mediterranean diet helps prevent CVD, microvascular complications in diabetes

2 days ago

Individuals with types 1 (T1D) and 2 diabetes (T2D) mellitus who adhere to a Mediterranean dietary pattern are at lower risk of cardiovascular disease (CVD) and microvascular complications, including diabetic retinopathy and nephropathy, a study has found.

Hypertension not uncommon in adults with cerebral palsy

Stephen Padilla, 3 days ago

A recent systematic review and meta-analysis has revealed that about one in three adults with cerebral palsy are hypertensive, which stresses the importance of clinical screening for blood pressure (BP) in these individuals beginning in young adulthood.

Healthy dietary habits help prevent cognitive decline with ageing

5 days ago

A healthy diet, defined by adherence to either the Mediterranean diet, the World Health Organization (WHO) guidelines, or Dutch Health Council dietary guidelines, is predictive of better cognitive function and slower cognitive decline with ageing from middle age onward, a study has shown.

Wearable sensors detect mild gait disturbances in early multiple sclerosis

Tristan Manalac, 5 days ago

Wearable inertial sensors can detect gait disturbances with high sensitivity even during the early stages of multiple sclerosis (MS), where established clinical global scales may miss slight deviations in gait, according to a recent study.

Salt substitute may slash stroke risk

Roshini Claire Anthony, 5 days ago

Swapping regular salt for a reduced-sodium salt substitute may cut stroke, major adverse cardiovascular event (MACE)*, and death rates in individuals with a risk of stroke, according to results of the SSaSS** trial.

Shifting paradigms in MS management: Early, optimized interventions improve patient outcomes

04 May 2018

Multiple sclerosis (MS) is one of the most common neurological disorders – affecting over 2.3 million people globally – and it is the leading cause of nontraumatic disability in young adults. However,the availability of supportive resources and services for people with MS is scarce in many regions of the world. In Malaysia, the prevalence of MS is estimated at 2-3/100,000; the current Malaysian clinical practice guidelines on the management of MS recommend disease modifying agents, such as interferon-β and teriflunomide, as first-line therapeutic agents. In this article, Dr Singer - in partnership with Sanofi and the Malaysian Society of Neurosciences - shares his insights into managing MS dynamically, highlighting the importance of early intervention in improving patient outcomes.

Hypertension and cholesterol lowering interventions do not reduce cognitive decline

Roshini Claire Anthony, 22 Nov 2016

Blood pressure lowering medications and statins do not prevent cognitive and functional decline in elderly patients, according to results of the HOPE-3 trial* presented at the Scientific Sessions of the American Heart Association (AHA 2016) held recently in New Orleans, Louisiana, US.

An uncommon cause of hyperthyroidism

Dr. Rose Zhao-Wei Ting, 16 Nov 2016

A 55-year-old man presented with almost one year history of heat intolerance, mild palpitation and significant weight loss. Free T3 and T4 were elevated with normal TSH. Patient had suboptimal response to carbimazole therapy.

High-dose aducanumab delays clinical decline across multiple domains in early AD

Elaine Soliven, 25 Aug 2021

Treatment with high-dose aducanumab shows less clinical decline across individual items or domains of cognition, function, and behaviour compared with placebo in patients with early symptomatic Alzheimer’s disease (AD), according to the EMERGE* study presented at AAIC 2021.

Subjective cognitive decline risk may be higher in transgender vs cisgender adults

Roshini Claire Anthony, 23 Aug 2021

Transgender adults had a higher likelihood of experiencing subjective cognitive decline (SCD) and SCD-related functional limitations compared with their cisgender counterparts, according to a study presented at AAIC 2021.

Short sleep duration in midlife may increase risk of dementia in later life

Elaine Soliven, 19 Aug 2021

Midlife adults aged between 50 and 70 years who reported a short sleep duration of ≤6 hours/night had an increased risk of developing dementia later in life, according to a study presented at AAIC 2021.

Is keto neuroprotective in individuals with impaired cognition?

Audrey Abella, 18 Aug 2021

Two studies presented at AAIC 2021 showed a potential neuroprotective effect of a ketogenic supplement or diet: In one study, consumption of a keto drink was associated with improvements in dorsal attention network (DAN) functional connectivity in mild cognitive impairment (MCI). Another study showed the keto diet’s potential to improve aberrant default mode network (DMN) connectivity patterns in adults at risk for Alzheimer’s disease (AD).