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Neurology
Top Medical News
Despite an extensive literature on the possible mechanisms involved in gut microbiota modulation and the pathophysiology of dementia, current evidence does not support clinical application of supplementation with probiotics and synbiotics to boost cognitive function in individuals with dementia, according to a meta-analysis.
Patients with type 2 diabetes mellitus (T2DM) may also sustain brain damage in regions of the brain involved in cognition and emotion, a new study has found. This provides structural bases for mood and cognitive deficits in T2DM patients.
After treatment with fremanezumab, a difficult-to-treat patient population with treatment-resistant episodic or chronic migraine saw sustained benefits across a broad range of measures, according to multiple analyses of the FOCUS study released during the AHS 2020 Virtual Meeting.
A recent UK nationwide, cross-specialty surveillance study on coronavirus disease 2019 (COVID-19) suggests that stroke, followed by altered mental state comprising encephalopathy or encephalitis and primary psychiatric diagnoses, are the most common complications, with altered mental state occurring as frequently in younger vs older patients.
The CGRP* receptor blocker erenumab shows sustained efficacy in reducing migraine frequency over 2 years in a difficult-to-treat patient population with episodic migraine who had failed 2–4 prior preventive treatments, an interim analysis of the LIBERTY** open-label extension study shows.
Among older adults, self-reported hearing difficulty is related to cognitive impairment, as mediated by social isolation, a study reports. SHD is also associated with physical disability.
Nursing home (NH) residents who develop out-of-hospital cardiac arrests (OHCAs) suffer from worse neurological outcomes, according to a recent Singapore study.
Special Reports
Multiple sclerosis (MS) is one of the most common neurological disorders – affecting over 2.3 million people globally – and it is the leading cause of nontraumatic disability in young adults. However,the availability of supportive resources and services for people with MS is scarce in many regions of the world. In Malaysia, the prevalence of MS is estimated at 2-3/100,000; the current Malaysian clinical practice guidelines on the management of MS recommend disease modifying agents, such as interferon-β and teriflunomide, as first-line therapeutic agents. In this article, Dr Singer - in partnership with Sanofi and the Malaysian Society of Neurosciences - shares his insights into managing MS dynamically, highlighting the importance of early intervention in improving patient outcomes.
Conference Reports
After treatment with fremanezumab, a difficult-to-treat patient population with treatment-resistant episodic or chronic migraine saw sustained benefits across a broad range of measures, according to multiple analyses of the FOCUS study released during the AHS 2020 Virtual Meeting.
The CGRP* receptor blocker erenumab shows sustained efficacy in reducing migraine frequency over 2 years in a difficult-to-treat patient population with episodic migraine who had failed 2–4 prior preventive treatments, an interim analysis of the LIBERTY** open-label extension study shows.
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
While aducanumab significantly reduced clinical decline in individuals with early Alzheimer's disease (AD) in one randomized trial, no changes were seen in another identical study — rendering the role of aducanumab in AD inconclusive.
Older adults who are excessively sleepy at daytime are twice as likely as their non-sleepy counterparts to develop either heart disease, cancer, or diabetes, a new research released at AAN 2020 has shown.
A new combination product (AXS-07), which consists of the triptan rizatriptan and the NSAID* meloxicam, led to rapid and sustained pain relief than treatment with either component alone or placebo in patients with a history of inadequate response to prior acute migraine treatment, according to data from the MOMENTUM study released during the AAN 2020 Meeting.
Treatment with risdiplam helps infants with Type 1 spinal muscular atrophy (SMA) gained significant motor functions, according to the FIREFISH Part 2 pivotal trial presented during the AAN 2020 Meeting.
