narcolepsy
NARCOLEPSY

Narcolepsy is a chronic neurologic sleep disorder wherein the patient have excessive daytime sleepiness and rapid eye movement sleep is dysregulated.

It affects 1 in 1000 individuals, with prevalence of about 0.04% of general population.
The exact cause remains unclear.
Studies suggest a combination of genetic predisposition, abnormal neurotransmitter functioning and abnormal immune modulation.
Symptoms include excessive daytime sleepiness, cataplexy, sleep paralysis, sleep-related hallucinations, automatic behavior, fragmented nocturnal sleep and insomnia.

Narcolepsy References

  1. Ahmed I, Thorpy M. Clinical features, diagnosis and treatment of narcolepsy. Clin Chest Med. 2010 Jun;31(2):371-381. PMID: 20488294
  2. Cao M. Advances in narcolepsy. Med Clin North Am. 2010 May;94(3):541-555. PMID: 20451031
  3. Black JE, Nishino S, Brooks SN. Narcolepsy and syndromes of central nervous system-mediated sleepiness. The Journal of Lifelong Learning in Psychiatry. 2005 Oct;3(4):585-597.
  4. Billiard M, Bassetti C, Dauvilliers Y, et al. EFNS guidelines on the management of narcolepsy. Eur J Neurol. 2006 Oct;13(10):1035-1048. PMID: 16987156
  5. Morgenthaler TI, Kapur VK, Brown T, et al. Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1705-1711. PMID: 18246980
  6. Didato G, Nobii L. Treatment of narcolepsy. Expert Rev Neurother. 2009 Jun;9(6):897-910. PMID: 19496692
  7. Khan F, Hazin R and Iqbal M. Narcolepsy: clinical decision making for the primary care physician. South Med J. 2009 Dec;102(12):1246-1252. PMID: 20016433
  8. Nishino S, Okuro M. Emerging treatments for narcolepsy and its related disorders. Expert Opin Emerg Drugs. 2010 Mar;15(1):139-158. PMID: 20166851
  9. Zeman A, Britton T, Douglas N, et al. Narcolepsy and excessive daytime sleepness. BMJ. 2004 Sep;329(7468):724-728. PMID: 15388615
  10. Chokroverty S. Sleep and its disorders. In: Bradley W, Daroff R, Fenichel G, et al, eds. Bradley: Neurology in Clinical Practice. 5th ed. Philadelphia: Butterworth Heinemann Elsevier; 2008
  11. Britton T, Douglas N, Hansen A, et al. Guidelines on the Diagnosis and Management of Narcolepsy in Adults and Children: Evidence-based Guidelines for the UK with Graded Recommendations. Ashtead, UK: Taylor Patten Communications Ltd; 2002
  12. MedWormhttp://www.medworm.com/rss/index.php/Neurology/25/http://www.medworm.com/rss/medicalfeeds/specialities/Neurology.xml
  13. American Psychiatric Association. Narcolepsy. In: Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013:372-373.
  14. Wise MS, Arand DL, Auger RR, et al. Treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1712-1727. PMID: 18246981
  15. Scamell TE. Clinical features and diagnosis of narcolepsy in adults. UpToDate. www.uptodate.com. Mar 2017.
  16. Thorpy MJ, Dauvilliers Y. Clinical and practical considerations in the pharmacologic management of narcolepsy. Sleep Med. 2015 Jan;16(1):9-18. doi: 10.1016/j.sleep.2014.10.002. PMID: 25458251
  17. Cao MT, Guilleminault C. Narcolepsy: diagnosis and management. In: Kryger MH, Roth T, eds. Principles and practice of sleep medicine. 6th. Philadelphia, PA: Elsevier's Saunders; 2017. :873-882.
  18. Chokroverty S, Avidan AY. Sleep and its disorders. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley’s neurology in clinical practice. 7th. Philadelphia, PA: Elsevier's Saunders; 2015. 1615-1685. :1615-1685.
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