narcolepsy
NARCOLEPSY

Narcolepsy is a chronic neurologic sleep disorder wherein the patient have excessive daytime sleepiness and rapid eye movement sleep is dysregulated.

It affects 1 in 1000 individuals, with prevalence of about 0.04% of general population.
The exact cause remains unclear.
Studies suggest a combination of genetic predisposition, abnormal neurotransmitter functioning and abnormal immune modulation.
Symptoms include excessive daytime sleepiness, cataplexy, sleep paralysis, sleep-related hallucinations, automatic behavior, fragmented nocturnal sleep and insomnia.

Narcolepsy Management

Prevention

Scheduled Naps

  • Regular scheduled short daytime naps can decrease sleepiness & improve alertness
    • Fifteen- to twenty-minute naps every 4 hours during daytime are recommended
    • Usually combined with other therapies

Other Management Approaches

  • Avoid sleep deprivation
  • Avoid frequent time zone changes
  • Practice good sleep hygiene
  • Regular exercise
    • Increases daytime energy & improves sleeping patterns

Follow Up

  • Regular follow-up every 6 months to 1 year is advised once stabilized on medication
    • Monitor compliance & response to treatment
    • Assess development of side effects (eg sleep disturbances, mood changes, cardiovascular & metabolic problems)
    • Assist patients in adapting to the disorder
Editor's Recommendations
Most Read Articles
23 Apr 2018
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Audrey Abella, 20 Mar 2020
The addition of highly purified cannabidiol (CBD) into an antiepileptic regimen led to reductions in convulsive seizure rates in children with Dravet syndrome (DS), the GWPCARE2* study has shown.
27 May 2020
High rather than low levels of neonatal 25(OH)D3 pose an increased risk of incident epilepsy in early childhood, a finding that may be attributed to chance, confounding, or late gestational vitamin D exposure, according to a study.
Jairia Dela Cruz, 29 Jan 2020
In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.