Myasthenia gravis is an autoimmune neurological disorder caused by autoantibodies against the acetylcholine receptor or against a receptor-associated protein, muscle-specific tyrosine kinase (MuSK-Ab).
The autoimmune attack at the muscle endplate leads to failure of neuromuscular transmission and eventually muscle weakness.
In the active phase of the disease, symptoms typically fluctuates and then become severe; myasthenic crisis occur in this phase.
In the stable/inactive phase, symptoms are stable but still persist; it usually worsen attributable to infection, fatigue, tapering of medications or other identifiable factors.
In the burnt-out phase, remission may occur wherein patients are on immunotherapy and symptom-free, or may even be off medications.
In 15-20 years, if the symptoms left untreated, patient's weakness becomes fixed wherein the most severely affected muscles become atrophic.
Combination therapy with alendronate plus alfacalcidol appears to produce significant increases in bone mineral density (BMD) and reductions in bone turnover biomarker levels, and to lower the rate of hypercalciuria in myasthenia gravis patients who initiated treatment with glucocorticoids, according to a study.
Among offspring of parents with bipolar disorder (OBP), resting-state functional connectivity (rsFC) between left inferior frontal gyrus (IFG) and clusters in the left insula (LINS) may be a risk marker for the development of bipolar disorder, suggests a study.
Exposure to ambient pesticides within 2,000 m of the mother’s residence during pregnancy increases the risk of autism spectrum disorder (ASD) in offspring, suggests a study. Moreover, risks for ASD with comorbid intellectual disability are further increased when infant is exposed to pesticides.