Multiple%20myeloma News

News

Idecabtagene vicleucel boosts PFS and responses vs standard regimens in triple class–exposed R/R MM

Christina Lau, 20230417000000

Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy, improves progression-free survival (PFS) and responses vs standard regimens in patients with triple class–exposed relapsed and refractory multiple myeloma (R/R MM), the phase III KarMMa-3 trial has shown.

Original New Drug Application Approvals by US FDA (16 - 31 October 2022)

20221102095557

New drug applications approved by US FDA as of 16 - 31 October 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Teclistamab demonstrates clinical activity for R/R MM

Audrey Abella, 20220811100000

The T-cell-redirecting bispecific antibody teclistamab induced deep and durable responses in patients with triple-class-exposed relapsed or refractory multiple myeloma (R/R MM), findings from the phase I/II MajesTEC-1 trial have shown.

Original New Drug Application Approvals by US FDA (16 - 31 July 2022)

20220731000000

New drug applications approved by US FDA as of 16 - 31 July 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Upfront ASCT + RVd improves PFS in NDMM

Roshini Claire Anthony, 20220716110001

Upfront autologous stem cell transplantation (ASCT) plus lenalidomide, bortezomib, and dexamethasone (RVd) significantly improves progression-free survival (PFS) in patients with newly diagnosed multiple myeloma (NDMM), results of the phase III DETERMINATION trial showed.

Post-transplant KRd a new SoC for MM?

Audrey Abella, 20220707100000

In the ongoing phase III ATLAS study evaluating patients with newly diagnosed multiple myeloma (MM), progression-free survival (PFS) was better with maintenance treatment with carfilzomib, lenalidomide, and dexamethasone (KRd) than lenalidomide (R) alone after autologous stem-cell transplantation (ASCT).

$Ixa-dex, pom-dex both effective in heavily pretreated relapsed, refractory multiple myeloma$

Ixa-dex, pom-dex both effective in heavily pretreated relapsed, refractory multiple myeloma

20220608180000

Ixazomib-dexamethasone (ixa-dex) and pomalidomide-dexamethasone (pom-dex) achieve comparable levels of efficacy and safety in relapsed and refractory multiple myeloma (RRMM) patients who had already been exposed to prior lenalidomide-based regimens, a recent study has found.

Original New Drug Application Approvals by US FDA (16 - 31 May 2022

20220531000000

New drug applications approved by US FDA as of 16-31 May 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Accelerated daratumumab infusion safe, well tolerated in multiple myeloma

20220529120000

Accelerated administration of daratumumab, an anti-CD3 monoclonal antibody approved for multiple myeloma, is safe and well tolerated when given following at least two standard infusions, suggest the results of a recent study.

High BMI might promote MGUS progression to multiple myeloma

20220517180000

In individuals with monoclonal gammopathy of undetermined significance (MGUS), obesity or high body mass index (BMI) seems to aggravate the risk of disease progression to multiple myeloma (MM), an effect that appears to be stronger in women, a recent study has found.

Carfilzomib-based triplet regimen a potential upfront treatment for high-risk MM

Pearl Toh, 22 Oct 2020

The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.

Product Highlight - Talzenna

13 Sep 2022

Talazoparib 0.25 mg hard cap

ALL treatment: Current settings, future goals

Roshini Claire Anthony, 08 Jan 2021

Significant advancements in the treatment of acute lymphocytic leukaemia (ALL) in children have improved their outcomes. However, ALL treatment and eradication remain a major challenge in adults. In a recent webinar, two specialists from the US discussed current ALL treatment strategies and goals of future regimens.