Multiple myeloma is a bone marrow disease characterized by the presence of malignant plasma cells, & abnormal serum &/or urine immunoglobulin secondary to clonal plasma cell expansion.

It accounts for 1-2% of all cancers worldwide & mostly affects patients at ages 65-74 years old.

Patient usually presents with bone pain & nonspecific symptoms, or due to abnormalities in laboratory exams.


Differential Diagnosis

  • Other plasma cell proliferative disorders
    • Include other plasma cell proliferative disorders that do not meet the criteria for multiple myeloma but may eventually progress into multiple myeloma
    • Solitary (Isolated) Plasmacytoma
      • Diagnostic criteria should include all of the following: Biopsy-confirmed solitary bone or soft tissue lesion w/ evidence of clonal plasma cells, normal bone marrow without any evidence of clonal plasma cells, normal skeletal survey & no abnormalities in CT & MRI except for a primary solitary lesion, & no evidence of end-organ damage (CRAB criteria) attributable to any plasma cell proliferative disorder
      • May progress into multiple myeloma (10% progression rate in 3 years)
    • Extramedullary plasmacytoma
    • Osteosclerotic myeloma (POEMS syndrome)
    • Waldenström macroglobulinemia
  • Light chain amyloidosis
  • Plasma cell leukemia
  • Heavy chain disease
  • Bone metastasis
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
06 Sep 2019
Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 5 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
05 Sep 2019
Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol and triglyceride but not high-density lipoprotein cholesterol, suggesting its usefulness for mitigating the risk of cardiovascular disease in patients with hypercholesterolaemia, according to the results of a meta-analysis.