Treatment with ultra-short-acting β-blockers, such as esmolol and landiolol, in sepsis and septic shock patients with persistent tachycardia leads to a significantly lower mortality at 28 days despite initial resuscitation, according to the results of a systematic review and meta-analysis.
People who were deprived of sleep (≤4 hours per night) or who slept excessively (≥10 hours per night) saw a faster cognitive decline than those with normal sleep duration (7 hours per night), shows a large cohort study.
Concomitant pathology of aortic stenosis (AS) and cardiac amyloidosis (CA) occurs frequently in older AS patients and has worse clinical presentation and prognosis unless treated, suggests a study. Hence, transcatheter aortic valve replacement (TAVR) must not be denied in AS-CA patients.
The mean amplitude of intraocular pressure excursion (MAPE) appears to be a valuable parameter to describe circadian fluctuations in intraocular pressure (IOP) in glaucoma patients, a recent study has found.
Use of nivolumab for the second-line treatment of advanced oesophageal squamous cell carcinoma yields numerical gains in survival as compared with chemotherapy in Asian patients, according to a subgroup analysis of the phase III ATTRACTION-3 trial.
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.