A once-daily oral dose of sofosbuvir and velpatasvir for 12 weeks leads to sustained virological response (SVR) in a majority of patients with chronic hepatitis C virus (HCV) infection, according to an Asian study. However, the efficacy of this regimen may be reduced in patients with HCV genotype 3b with cirrhosis.
A recent study has shown that higher blood pressure (BP) during early pregnancy and greater decreases in BP from early to mid-pregnancy heightens the risk of small-for-gestational-age (SGA) birth, which suggests a range of risk for SGA birth according to BP beginning at early pregnancy.
There appears to be no significant difference in physical activity and amount of sleep between night float and on-call residents, according to a Singapore study. Residents on night float report relatively more fatigue and burnout.
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
The effectiveness and haematologic toxicity of a carboplatin-based chemotherapy are similar to those of cisplatin in the adjuvant treatment of resected nonsmall cell lung cancer (NSCLC), according to a study.
The Test Your Memory (TYM) screen, when combined with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and supplemented with executive and language tests such as the Colour Trail Test (CTT) and modified Boston Naming Test (mBNT), effectively detects cognitive impairment (CI), according to a recent Singapore study.
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.