Desmopressin (DDAVP) appears to be effective in reducing the rate of change in plasma sodium concentration, such that the proactive and reactive strategies of use result in safe correction of sodium levels in hyponatraemic patients at average risk of osmotic demyelination, a recent study has shown.
Treatment with beta-blockers does not appear to influence lung function, overall respiratory status and safety of tiotropium/olodaterol in patients with moderate to very severe chronic obstructive pulmonary disorder (COPD), according to data from the TONADO research programme.
Semaglutide appeared to render better reductions in HbA1c and weight compared with dulaglutide in individuals whose type 2 diabetes (T2D) was inadequately controlled on metformin, according to findings of the SUSTAIN 7* trial.
Administering intravitreal injections of ranibizumab in addition to panretinal photocoagulation (PRP) appears to be more effective than PRP monotherapy in terms of neovascularization regression in patients with high-risk proliferative diabetic retinopathy, according to a study.
A weekly dose escalation of regorafenib was superior to starting with the standard dose of 160 mg/day for patients with refractory metastatic colorectal cancer (mCRC), according to the ReDOS* trial presented at the ASCO GI Cancers Symposium 2018.
The risk of major bleeding, including intracranial bleeding, major or clinically relevant nonmajor bleeding, as well as cardiovascular and all-cause death is greater in patients with atrial fibrillation and a history of falling who are treated with anticoagulants, according to a study. Regardless of falls history, the efficacy and safety of apixaban vs warfarin are consistent.
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.