Post-menopausal women diagnosed with oestrogen receptor (ER)-positive ductal carcinoma in situ (DCIS) who undergo breast-conserving surgery followed by whole breast radiotherapy have a reduced risk of developing local recurrence, according to a study from Italy.
Targeted antibiotic prophylaxis – after a rectal swab to identify specific intestinal flora – does not appear to significantly impact the risk of urinary sepsis following a transrectal ultrasound (TRUS)-guided prostate biopsy, according to a recent study.
Long‐term treatment with perampanel in the adjunctive setting appears to provide improved seizure control without raising new safety/tolerability signals in patients with epilepsy, particularly those with secondarily generalized seizures at baseline, according to the results of an open-label extension of phase III trials.
Academic decline in primary and secondary school appears to precede overt clinical symptoms of depression, a UK study reports. Furthermore, self-harm behaviour is associated with poor academic performance but during secondary school only.
Concomitant use of direct oral anticoagulants (DOACs) and amiodarone, a dual P-glycoprotein (p-gp)/ cytochrome p-450 (CYP3A4) inhibitor, appears to have no influence on the efficacy and safety outcomes in patients with atrial fibrillation, suggest the results of a recent meta-analysis.
Same-day regimens (SaDs) are on a par with specific-dose regimens (SpDs) with regard to bowel cleanliness, cecal intubation rate (CIR) and adenoma detection rate (ADR), results of a recent meta-analysis have shown. However, SaDs appear to be better than SpDs in preparation quality with bisacodyl.
In the management of paediatric bronchiolitis, high-flow oxygen therapy appears to be superior to standard oxygen therapy in terms of rate of escalation of care due to treatment failure, according to the results of a trial.
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.