Initiation of sacubitril-valsartan combo during hospitalization in Asian patients with heart failure with reduced ejection fraction (HFrEF) appears to lead to a higher incidence of adverse drug reactions (ADRs) and treatment discontinuation when compared with starting the patients on the drug as an outpatient, according to real-world data.
The population-based risk prediction algorithm QCOVID demonstrates very high levels of discrimination for deaths and hospital admissions due to the novel coronavirus disease (COVID-19), according to the results of a national derivation and validation cohort study.
Replacing sugar-sweetened beverages (SSBs) with noncaloric drinks such as artificially sweetened beverages (ASBs) or unsweetened beverages (USBs) did not affect the serum triglyceride-HDL-C ratio (TG:HDL-C) of adults who report regular SSB intake, a study has shown. However, doing so had a favourable impact on body weight and central adiposity, while USBs trumped the other two beverage types in terms of sweet taste preference.
An estimated 463 million adults – about one in 11 – had diabetes in 2019. These numbers are expected to rise to 700 million by 2045. Worse, one in two people are undiagnosed. [https://www.idf.org/, accessed 19 October 2020]
A community initiative targeted at metastatic breast cancer (mBC) patients has recently been launched by the Breast Cancer Welfare Association Malaysia (BCWA). Called #UnPause, the initiative aims to rally mBC patients to live their lives to the fullest. It further aims to raise awareness of mBC among the public and prevent treatment disruption as a result of the COVID-19 pandemic. #UnPause is also supported by Pfizer.
Practising yoga for 30 minutes at least thrice weekly reduces patient-reported symptoms of atrial fibrillation (AF) — bringing to light a potential noninvasive, medication-free intervention for managing a costly disease that is AF.
Durvalumab with or without tremelimumab in the first-line setting does not improve overall survival (OS) over standard-of-care (SoC) chemotherapy in patients with unresectable, locally advanced or metastatic urothelial carcinoma, according to the phase III DANUBE trial.
Having vaccination against influenza during pregnancy was not associated with an increased risk of autism spectrum disorder (ASD) in the offspring, a large cohort study reveals — providing more support for vaccination during pregnancy.
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Despite a 90-percent cure rate after first treatment for children with acute lymphoblastic leukaemia (ALL), approximately 10–15 percent of patients with paediatric ALL will experience relapse. [Expert Rev Anticancer Ther 2017;17:725-736] A recent webinar on the current landscape of ALL highlighted the potential of immunotherapy for paediatric patients with relapsed or refractory ALL, thus providing hope for this high-risk patient group.