Diuretic therapy in primary hypertension results in a sustained increase in plasma renin activity (PRA), which is similar across different diuretics classes and is not related to the average reduction in blood pressure (BP), according to the results of a systematic review and meta-analysis.
In individuals with resected oesophageal or gastro-oesophageal junction (GEJ) cancer who have received neoadjuvant chemoradiotherapy (CRT), adjuvant nivolumab therapy demonstrated superior efficacy over placebo, according to the CheckMate 577 trial.
Digital biomarkers collected by smartphones and wearable sensors may help detect behavioural and physiological changes signalling symptom burden in pancreatic cancer patients before and after surgery, according to a recent study.
Undergoing a structured weight loss programme after ablation for atrial fibrillation (AF) does not confer significant reduction in AF burden compared with usual care, according to the SORT-AF* study presented at EHRA 2021.
The anti-PD-1 antibody tislelizumab may help improve patient outcomes vs docetaxel as second- or third-line treatment for advanced or metastatic non–small-cell lung cancer (NSCLC) regardless of histology or PD-L1 expression, interim findings from the phase III RATIONALE 303 study have shown.
Niraparib maintenance therapy improved progression-free survival (PFS) in patients with platinum-sensitive recurrent ovarian cancer (PSROC) regardless of time to progression since penultimate platinum chemotherapy or response to last chemotherapy, according to subgroup analyses of the NORA trial.
Low bone mineral density (BMD), on its own, is predictive of a heightened risk of atherosclerotic cardiovascular disease (ASCVD) in women, as well as provides an incremental prognostic value over age and other clinical risk factors, as shown in a study from Korea.
A web-based mobile application (app) called MyCOVIDRisk estimates the risk of COVID-19 transmission and has been found to be feasible and acceptable among the US public, a study has shown. Transmission risk can be estimated for app users, without collecting personal health data, based on local prevalence of disease, type of activity, and mitigation measures employed.
The combination of the immune checkpoint inhibitor atezolizumab and the angiogenesis inhibitor bevacizumab continues to demonstrate significant clinical benefits vs the oral multikinase inhibitor sorafenib in patients with unresectable hepatocellular carcinoma (HCC), according to updated results from the IMbrave150 trial.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
The effect of cannabidiol (CBD) in the treatment of patients with Lennox–Gastaut syndrome may occur within 7 days of initiation, and most adverse events resolve within a 14-week period, a study reports.
In a webinar held on 27 March 2021, paediatric
endocrinology nurses Karen Blair,
Kate Davies, and Siti Zarina Yaakop shared
insights and clinical experience based
on their frontline roles in caring for patients
with central precocious puberty (CPP)
and supporting their family members.