Foregoing intracardiac electrophysiologic mapping was as good as conventional cryoablation with pulmonary vein (PV) mapping in the AVATAR-HF* study, suggesting that a simplified procedure could produce the same outcomes for lower costs.
Use of uninterrupted edoxaban during catheter ablation for atrial fibrillation (AF) shows comparable safety and efficacy as uninterrupted vitamin K antagonists (VKAs), according to the ELIMINATE-AF trial presented at EHRA 2019.
Patients on the anticoagulant drug edoxaban could safely continue their treatment while undergoing certain procedures, with a low incidence of bleeding and cardiovascular events reported in the prospective EMIT AF/VTE* study.
Remote monitoring (RM) reduced hospitalization rates in patients with heart failure (HF) and implanted cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D), according to data from the RESULT* trial presented at EHRA 2019.
Patients who have recently experienced atrial fibrillation (AF) could benefit from treatment with upfront rate-control medication rather than undergoing immediate cardioversion to restore sinus rhythm, according to The Netherlands-based RACE 7 ACWAS* trial.
A two-part tilt training programme designed to retrain the autonomic nervous system (ANS) to respond correctly to move to an upright position effectively prevented reflex syncope (RS) or fainting episodes, offering patients an improved quality of life (QoL) and ability to return to work, according to data presented at EHRA 2019.
Use of high doses of the dihydropyridine nifedipine was associated with a higher risk of out-of-hospital cardiac arrest (OHCA) than nonuse of dihydropyridines, according to data from two large registries under the ESCAPE-NET* presented at EHRA Congress 2019.
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Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.