Once-weekly subcutaneous administration of the novel recombinant, humanized, IgG4 bispecific antibody emicizumab prevents or reduces bleeds in patients with haemophilia A and factor VIII inhibitors in the phase III HAVEN 1* trial, offering a potential new standard of care for this severe bleeding disorder.
Rosuvastatin led to improved coagulation profile, in particular lower levels of factor VIII procoagulant activity (VIII:C), among patients who had venous thrombosis (VT) previously, suggesting that statins could reduce the risk of recurrent VT, according to a study presented at the ISTH 2017 Congress in Berlin, Germany.
Gene-transfer therapy using adeno-associated virus in patients with severe haemophilia A resulted in sustained levels of coagulation factor VIII (FVIII) expression within 1 year of observation, reducing spontaneous bleeds and FVIII infusions in most patients, interim results of a phase 1/2 dose-escalation study have shown.
Idarucizumab, a dabigatran-reversing humanized monoclonal antibody fragment, rapidly, completely, and durably reversed the anticoagulant effect of dabigatran in elderly patients with life-threatening bleeding or undergoing invasive medical interventions, according to a full cohort analysis of the RE-VERSE AD* study presented at the ISTH 2017 Congress in Berlin, Germany.
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Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.