Durvalumab with or without tremelimumab in the first-line setting does not improve overall survival (OS) over standard-of-care (SoC) chemotherapy in patients with unresectable, locally advanced or metastatic urothelial carcinoma, according to the phase III DANUBE trial.
A combined regimen of atezolizumab and nanoparticle albumin-bound (nab)-paclitaxel (A+nP) improves overall survival (OS) vs placebo plus nab-paclitaxel (P+nP) in patients with previously untreated, inoperable, locally advanced or metastatic, PD-L1 immune cell (IC)–positive triple-negative breast cancer (TNBC), according to the final analysis of the IMpassion130 study.
First-line cemiplimab significantly improved overall survival (OS) and progression-free survival (PFS) in patients with advanced NSCLC* with PD-L1** tumour expression of ≥50 percent, according to the EMPOWER-Lung 1*** study presented at ESMO 2020.
Surufatinib, a novel small-molecule inhibitor that targets tumour angiogenesis and immune evasion, improves progression-free survival (PFS) in patients with progressive, advanced, well-differentiated pancreatic neuroendocrine tumours (pNETs), according to results of the SANET-p trial presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.
In patients with stage IB–IIIA EGFR-mutated (EGFRm) non-small-cell lung cancer (NSCLC) who have undergone complete tumour resection, adjuvant osimertinib significantly reduces the risk of recurrence, including in the central nervous system (CNS), results of an exploratory analysis of the phase III ADAURA trial have shown.
Individualized starting dose (ISD) of maintenance niraparib improves progression-free survival (PFS) vs placebo in Chinese patients with platinum-sensitive recurrent ovarian cancer (PSROC), results of the NORA trial have shown.
Pembrolizumab in combination with chemotherapy significantly improves overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) vs chemotherapy alone in patients with previously untreated, locally advanced unresectable or metastatic oesophageal cancer, according to results of the phase III KEYNOTE-590 study presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.
The PD-1 inhibitor nivolumab continues to yield sustained recurrence-free survival (RFS) benefit over ipilimumab with better tolerability at 4 years in the adjuvant setting for patients with resected stage IIIB–C or IV melanoma, according to the CheckMate238 trial presented at ESMO 2020.
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The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.