Adding the CDK4/6 inhibitor abemaciclib to endocrine therapy improves progression-free survival (PFS) in first-line treatment of hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer, according to results of the phase III MONARCH 3 study presented at the European Society for Medical Oncology (ESMO) 2017 Congress in Madrid, Spain. [ESMO 2017, abstract 236O_PR]
Osimertinib nearly doubled progression-free survival (PFS) compared with conventional EGFR tyrosine kinase inhibitors (EGFR-TKIs) given as first-line treatment for EGFR-mutated non-small-cell lung cancer (NSCLC), according to a late-breaking report at the European Society for Medical Oncology (ESMO) 2017 Congress in Madrid, Spain. [ESMO 2017, abstract LBA2_PR]
Contradicting the common notion that small, early breast tumours are less aggressive, a subgroup analysis of the MINDACT trial reported recently at the European Society for Medical Oncology (ESMO) 2017 Congress in Madrid, Spain, demonstrated that nearly a quarter of such tumours were aggressive by genetic criteria, and patients with those tumours derived a benefit from neoadjuvant chemotherapy.
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
It takes just less than 4 days for COVID-19 to spread from one person to another and cause symptoms, and more than 10 percent of the cases are infected by a person who has caught the virus but yet to show symptoms, recent studies suggest.