A maintenance regimen comprising olaparib and bevacizumab led to greater progression-free survival (PFS) in patients newly diagnosed with advanced ovarian cancer, results of the phase III PAOLA-1/ENGOT-ov25* study showed.
Men with metastatic castration-resistant prostate cancer (mCRPC) derived significantly greater clinical benefit from cabazitaxel vs the androgen receptor-targeted agents (ARTA) abiraterone or enzalutamide, according to the results of the CARD* trial presented at ESMO 2019.
Final overall survival (OS) results from the double-blind phase III FLAURA study reinforce osimertinib as the standard frontline treatment for epidermal growth factor receptor-mutated (EGFRm) non–small cell lung cancer (NSCLC), say leading oncologists at ESMO 2019.
Nivolumab, used in the first-line treatment of patients with advanced hepatocellular carcinoma (HCC), has demonstrated clinically meaningful improvements in overall survival (OS) and response rates vs sorafenib in the phase III CheckMate 459 study, although the improvement in OS did not reach statistical significance.
The addition of upfront docetaxel chemotherapy to androgen deprivation therapy (ADT) confers durable and clinically significant benefit in men with hormone-naïve metastatic prostate cancer (mHNPC) regardless of metastatic burden, according to a long-term follow-up of the phase III STAMPEDE* trial reported at ESMO 2019.
Immunotherapy with pembrolizumab appears to increase response rates compared with single-agent chemotherapy in malignant pleural mesothelioma (MPM) patients who have failed a previous line of platinum-based chemotherapy, but this improved response does not translate to survival advantage, according to the results of the phase III PROMISE-meso trial presented at the 2019 Congress of the European Society for Medical Oncology (ESMO).
Systemic treatment tailored by molecular gene expression analysis has failed to improve outcomes of patients with carcinoma of unknown primary origin (CUP), according to the results of the GEFCAPI 04 trial presented at the 2019 Congress of the European Society for Medical Oncology (ESMO 2019).
There appears to be no pressing need for men with prostate cancer to undergo radiotherapy immediately after surgery, according to a recent study presented at the 2019 Congress of the European Society of Medical Oncology (ESMO 2019).
Blood-first next-generation sequencing leads to identification of ALK fusions in patients with nonsmall cell lung cancer, which in turn guides treatment decision-making, according to the initial results of the phase II/III B-FAST* trial presented at the European Society for Medical Oncology (ESMO) Congress 2019.
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Despite a 90-percent cure rate after first treatment for children with acute lymphoblastic leukaemia (ALL), approximately 10–15 percent of patients with paediatric ALL will experience relapse. [Expert Rev Anticancer Ther 2017;17:725-736] A recent webinar on the current landscape of ALL highlighted the potential of immunotherapy for paediatric patients with relapsed or refractory ALL, thus providing hope for this high-risk patient group.