Treatment with the DPP 1* inhibitor brensocatib prolonged time to exacerbation and reduced exacerbation rates in patients with non-cystic fibrosis bronchiectasis, according to the phase II WILLOW** study presented at ERS 2020.
The first-in-class oral tyrosine kinase inhibitor (TKI) masitinib demonstrated a positive benefit-risk profile over a sustained period in patients with severe persistent asthma regardless of baseline eosinophil level, with the greatest benefit seen among those with the highest oral corticosteroid (OCS) dependency, according to data presented at ERS 2020.
Vitamin D therapy and bariatric surgery in obese asthmatic patients both improve peripheral blood mononuclear cells (PBMC) sensitivity to the in vitro corticosteroid (CS) treatment, results of a Spain study have shown.
Asthma manifests differently between patients from urban and rural areas, likely due in part to differing environments, according to a recent study presented at the virtual International Congress 2020 of the European Respiratory Society (ERS 2020).
In children with asthma, genotype testing identifies a specific genetic alteration associated with poor response to long-acting β2 agonist (LABA), as shown in the PACT trial. This information proves useful in prescribing appropriate medications and improving asthma control.
Frequent coughing at night, measured using a smartphone app, appears to be a reliable indicator of worsening asthma, as reported in a study presented at this year’s European Respiratory Society (ERS) virtual meeting.
Gefapixant, a first-in-class non-narcotic, oral P2X3 receptor antagonist, significantly reduces cough frequency in patients with refractory or unexplained chronic cough, according to two COUGH* studies presented at ERS 2020.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.