eCritical Care Reviews Meeting 2021 (eCCR21)

Baclofen may reduce alcohol-related agitation in ICU

Roshini Claire Anthony, 20210301160001

Daily doses of baclofen may help reduce the risk of agitation among individuals with unhealthy alcohol use admitted to the intensive care unit (ICU), according to results of the BACLOREA* trial presented at eCCR 2021.

Oral hygiene in the ICU: Doing away with oral chlorhexidine prophylactic rinse

Jairia Dela Cruz, 20210222140000

De-adoption of the practice of swabbing the mouth with chlorhexidine for the prevention of ventilator-associated pneumonia (VAP) in the intensive care unit (ICU) and implementing a standard oral care bundle does not necessarily reduce mortality, infection-related ventilator-associated complications (IVACs), or procedural pain, according to the results of the CHORAL study.

Dexamethasone lowers mortality, ventilation use in ARDS

Stephen Padilla, 20210222120000

Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.

Systemic corticoids cut death risk in critically ill COVID-19 patients

Tristan Manalac, 20210222090000

The systemic use of corticosteroids lowers 28-day all-cause mortality among patients with the novel coronavirus disease (COVID-19), as opposed to usual care or placebo, according to the REACT* meta-analysis presented at the recently concluded eCritical Care Reviews Meeting 2021 (eCCR21).

Genetic underpinnings of severe, life-threatening COVID-19 uncovered

Tristan Manalac, 20210220090000

The propensity of the novel coronavirus disease (COVID-19) to develop into a severe and life-threatening disease appears to be influenced by genetics, according to the GenOMICC* study, whose results were recently presented at the eCritical Care Reviews Meeting 2021 (eCCR21).

Lower oxygenation target in ICU does not improve mortality

Roshini Claire Anthony, 20210219180001

In patients with acute hypoxemic respiratory failure admitted to the intensive care unit (ICU), a lower oxygenation target does not lead to a lower mortality rate, according to results of the HOT-ICU* trial presented at eCCR 2021.

NONSEDA: Some mechanically ventilated ICU patients need not be sedated

Jairia Dela Cruz, 20210219140000

Among critically ill adults receiving mechanical ventilation in the intensive care unit (ICU), a protocol of no sedation is comparable to light sedation with daily interruption in terms of mortality, as shown in the NONSEDA trial.

Lower acute kidney injury risk with dabigatran over warfarin in Asians with NVAF

STARRT-AKI: Is early better than delayed renal-replacement therapy in AKI patients?

Stephen Padilla, 20210219120000

An accelerated renal-replacement strategy does not appear to reduce the risk of mortality at 90 days among critically ill patients with acute kidney injury (AKI) compared to a standard strategy, according to the results of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial.

VHA no better than CCT in guiding haemostatic therapy for trauma

Stopping bleeding after trauma: VHA no better than CCT

Pearl Toh, 20210217143501

Adding Viscoelastic Haemostatic Assay (VHA) to empiric standard major haemorrhage protocol (MHP) in management of trauma did not improve overall outcomes compared with conventional coagulation test (CCT)-guided interventions, according to the ITACTIC* study presented at eCCR 2021.

OK to RELAx PEEP levels for ventilation of ICU patients without ARDS: latest study

Pearl Toh, 20210210143500

Invasive ventilation using a lower positive end-expiratory pressure (PEEP) strategy was noninferior to higher PEEP in ICU* patients without acute respiratory distress syndrome (ARDS), according to the RELAx** study presented at eCCR 2021.