Long-term treatment with the interleukin-5
receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.
Use of the novel application (app) CureApp Smoking Cessation (CASC) results in a significantly higher continuous abstinence rate (CAR) from weeks 9 to 24 compared to the control app, making it a promising tool for smoking cessation treatment, according to a study presented at the American Thoracic Society (ATS) 2019 International Conference.
The use of budesonide-formoterol, combined in a single preventer-reliever inhaler, on an as-needed basis more than halves the rate of asthma exacerbations in patients with mild asthma compared with the reliever albuterol used as needed, according to the Novel START* study presented at ATS 2019.
Switching from mepolizumab to benralizumab led to a significant reduction in oral corticosteroid (OCS) dose and a better QoL* in patients with severe eosinophilic asthma (SEA), according to a small study presented at ATS 2019.
The reduced mortality/morbidity benefit previously demonstrated with selexipag in patients with pulmonary arterial hypertension (PAH) may be more pronounced when treatment is initiated soon after diagnosis, according to results of a post hoc analysis of the GRIPHON* study presented as a poster at ATS 2019.
Diagnosis of gastro-oesophageal reflux disease (GERD) remains unclear in patients with subacute/chronic cough, especially those with low blood eosinophil counts ≤150/μl, but using the Frequency Scale for the Symptoms of GERD (FSSG) questionnaire may considerably help, suggests a study presented at the recent American Thoracic Society (ATS) 2019 International Conference held at Dallas, Texas in the US.
Treatment with dupilumab, a fully human monoclonal antibody that inhibits interleukin (IL)-4 and IL-13 signalling, significantly reduces severe exacerbation rate and improves lung function in patients with late-onset asthma, according to results of a post hoc analysis of the Liberty Asthma Quest* trial presented at ATS 2019.
Bariatric surgery plays a role in the treatment of obstructive sleep apnoea (OSA), inducing improvements in apnoea-hypopnea index (AHI), symptoms and consequences, although the effect appears to be greater on the last two, according to an expert who spoke at the American Thoracic Society (ATS) 2019 International Conference.
Unrecognized severe obstructive sleep apnoea (OSA) intensifies the risk of postoperative cardiovascular complications among at-risk adults receiving major noncardiac surgery, according to a new study presented at the recently concluded 2019 International Conference of the American Thoracic Society (ATS 2019).
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.