Adding selexipag to the double combination therapy of macitentan and tadalafil (triple combination) improved multiple outcomes in patients newly diagnosed with pulmonary arterial hypertension (PAH), results of the phase IIIb TRITON* trial showed.
Noninvasive ventilation (NIV) may not be the most suitable alternative for managing obesity hypoventilation syndrome (OHS) with or without severe obstructive sleep apnoea (OSA), according to subanalyses results of the Pickwick trial presented at ATS 2020.
The first-in-class tyrosine kinase inhibitor masitinib significantly reduces severe asthma exacerbations in patients who are uncontrolled on oral corticosteroids (OCS), regardless of their baseline eosinophil counts, according to a study presented at the ATS 2020 Virtual Meeting.
Interim analyses of the INBUILD trial presented at ATS 2020 continue to reflect the benefit of the tyrosine kinase inhibitor nintedanib for individuals with progressive fibrosing interstitial lung diseases (ILDs).
A fixed-dose triple therapy of ICS, LAMA, and LABA* is superior to dual therapies of either LAMA-LABA or ICS-LABA for controlling exacerbations in patients with moderate-to-very-severe COPD**, according to the large ETHOS*** trial.
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In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.