American Association for Cancer Research (AACR) Annual Meeting 2022

Novel cellular therapy produces impressive responses in heavily pretreated CD30-positive lymphoma

Kanas Chan, 20220519031535

A novel cellular therapy that links the bispecific antibody AFM13 with cord blood–derived natural killer cells (AFM13-NK), when used at recommended phase II dose (RP2D), produces a 100 percent overall response rate (ORR) in patients with refractory or relapsed CD30-positive Hodgkin or non-Hodgkin lymphomas (HL/NHL), according to results of the NCT04074746 trial presented at American Association for Cancer Research (AACR) 2022.

Stem cell–like epigenetic signature predicts resistance to CD19 CAR T-cell therapy in ALL

Sarah Cheung, 20220517060000

A stem cell–like epigenetic signature is identified in pretreatment samples from young patients with acute lymphoblastic leukaemia (ALL) who are resistant to CD19 chimeric antigen receptor (CAR) T-cell therapy, with potential utility for refining patient selection for appropriate treatment.

Sotorasib continues to impress at 2 years in KRAS G12C–mutant NSCLC

Elvira Manzano, 20220513000000

Long-term findings from the pooled phase I/II CodeBreak 100 trial support the efficacy of sotorasib in certain patients with KRAS G12C–mutant non–small cell lung cancer (NSCLC).

Neoadjuvant nivolumab plus chemo: New SoC in resectable NSCLC

Christina Lau, 20220513000000

In patients with resectable non-small-cell lung cancer (NSCLC), neoadjuvant nivolumab in combination with platinum-based chemotherapy significantly improves event-free survival (EFS) and shows a trend towards better overall survival (OS) vs chemotherapy alone, without impeding the feasibility of surgery or increasing adverse events (AEs), according to results of the phase III CheckMate 816 trial.

SWOG S1616 suggests PFS benefit with ipi-nivo combo in metastatic/unresectable melanoma

Roshini Claire Anthony, 20220512180001

The combination of ipilimumab and nivolumab may provide a progression-free survival (PFS) benefit in patients with metastatic or unresectable melanoma who did not respond to anti-PD-1/anti-PD-L1 therapy, according to a small study presented at AACR 2022.

Sotorasib demonstrates durable efficacy in KRASG12C-mutated NSCLC

Christina Lau, 20220511051930

The KRAS^G12C inhibitor sotorasib has demonstrated durable efficacy in patients with locally advanced or metastatic KRAS^G12C-mutated non-small-cell lung cancer (NSCLC), with 2-year overall survival (OS) reported in one-third of patients in the CodeBreaK 100 trial.

Adding canakinumab to SoC confers no survival benefit in advanced NSCLC

Roshini Claire Anthony, 20220510180001

The addition of the monoclonal anti-interleukin-1β antibody canakinumab to the standard of care (SoC) regimen of platinum doublet chemotherapy and pembrolizumab in the first-line setting did not improve progression-free survival (PFS) or overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC), results of the phase III CANOPY-1 trial showed.

New chemo-free triplet regimen shows promise for endometrial cancer

Audrey Abella, 20220509100000

A triplet regimen combining the PARP inhibitor olaparib with metronomic cyclophosphamide and metformin showed favourable signals for heavily pretreated women with advanced endometrial carcinoma, the phase I/II ENDOLA study suggests.

Adebrelimab plus chemo almost doubles OS, triples PFS in extensive-stage SCLC

Elvira Manzano, 20220506000000

Adding adebrelimab to chemotherapy improves survival outcomes over chemotherapy alone in patients with extensive-stage small cell lung cancer (SCLC) in the phase III CAPSTONE-1 study presented at AACR 2022. This brings hope to SCLC patients with limited treatment options and poor prognoses.