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Multidisciplinary
Top Medical News
COVID-19 patients carry particularly high viral loads during the early stages of the disease, with millions of virus exhaled in their breath per hour, reveals a study — which indicates that breath emission could possibly contribute to airborne transmission of the virus.
Nearly half of critically ill adolescent and young adult patients who received vancomycin develop acute kidney injury (AKI), according to a study.
A 4-week delay in cancer treatment can increase mortality across surgical, systemic treatment, and radiotherapy indications for seven cancers, with longer delays being more and more harmful to patients, suggest the results of a systematic review and meta-analysis.
Giving crushed prasugrel to patients with ST-segment elevation myocardial infarction (STEMI) en route to the hospital for planned PCI* does not improve reperfusion rates compared with giving the tablets whole in the COMPARE CRUSH trial.
A study has found that the LENT, modified-LENT, and PROMISE scores have poor accuracy of survival prognostication in Asian patients with malignant pleural effusion (MPE) undergoing pleuroscopy.
VP-102, a proprietary, drug-device combination containing cantharidin 0.7% (w/v), was effective and safe for treating molluscum contagiosum (MC), according to the phase III CAMP* trials.
Meteorological factors, such as humidity, precipitation, ambient temperature, and wind speed, seem to affect the transmissibility of the respiratory syncytial virus (RSV), according to a recent Singapore study.
Special Reports
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
At the recent Pfizer webinar “Pneumococcal Vaccination in High-Risk Individuals: Are We Doing It Right?”, Dr Petrick Periyasamy, head of the Hospital Canselor Tuanku Muhriz UKM Infectious Diseases Unit, discussed the currently known epidemiology of adult pneumococcal disease (PD),as well as the impact of vaccines on PD prevention in at-risk populations.
Dacomitinib 15 mg FC tab
Alpelisib 50 mg, 150 mg and 200 mg FC tab
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
At a Pfizer-sponsored webinar held in collaboration with the Malaysian Medical Association, several distinguished speakers shared their insights into the current SARSCOV-2 pandemic, better known as COVID-19. Topics discussed include current and future therapeutic interventions from both local and global perspectives.
Heart failure (HF) is a global public health concern, affecting about 38 million individuals globally.1 Despite significant medical advances, HF remains a chronic and progressive condition that can negatively affect patients’ quality of life (QoL).2,3 In this case study, Dr Abdul Muizz shares his clinical experience in managing a patient with HF and reduced ejection fraction (HFrEF), following the percutaneous coronary intervention, showing how the initiation of sacubitril/valsartan therapy (an angiotensin receptor/neprilysin inhibitor [ARNI]) changed the clinical outcome of this patient.
Conference Reports
An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.
HIV patients hospitalized for COVID-19 are at a higher risk of mortality than those hospitalized without HIV in a new study reported at HIV Glasgow 2020.
Using regional citrate for anticoagulation during dialysis significantly extends the lifespan of dialysis filter compared with systemic heparin anticoagulation, although this has no impact on the patients’ mortality rate over 1 year, according to the RICH study presented at ASN 2020.
The efficacy of lanifibranor in reducing histological markers of non-alcoholic steatohepatitis (NASH) is comparable in patients with and without type 2 diabetes (T2D), according to the phase IIb NATIVE study presented as a poster at AASLD 2020.
Use of the potent and selective PPARδ* agonist seladelpar led to improvements in histologic responses and liver chemistry in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH), a phase II study has shown.
Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.
Reductions in liver fat and adipose tissue volumes were sustained in patients with type 2 diabetes (T2D) with the addition of the SGLT-2* inhibitor dapagliflozin (DAPA) and the DPP-4** inhibitor saxagliptin (SAXA) to metformin (MET), compared with a regimen comprising glimepiride (GLIM)+MET, according to the extension period results of a phase IIIb trial.
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