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Hepatic recruitment of eosinophils appears to play a protective role during acute liver injury caused by acetaminophen overdose, reveals a recent study.
Treatment with secukinumab 300 mg significantly improves symptoms of biologic-naïve patients with psoriatic arthritis (PsA) compared with placebo, results from the CHOICE study have shown.
Adherence to a healthy diet can help reduce the risk of heart failure (HF) with reduced ejection fraction (HFrEF), as seen in both the Alternative Healthy Eating Index (AHEI) and the clinically abbreviated Prime Diet Quality Score (PDQS), reveals a study.
Hope springs yet again in the field of HIV treatment, as another HIV patient (reportedly the fourth in the world) goes into remission 3 decades following diagnosis. The patient stopped antiretroviral therapy (ART) after receiving allogeneic hematopoietic stem cell transplantation (HCT) of CCR5-Δ32/Δ32 donor cells for acute myelogenous leukaemia (AML).
ClickCheck, a portable and low-cost refractive error measurement device, demonstrates a high level of agreement with the standard-practice subjective refraction (SR) in terms of spherical power, according to a recent study. Nevertheless, improvements are needed to yield better cylindrical power evaluations.
The time in target rage (TTR) of systolic blood pressure (SBP) appears to be predictive in assessing the risk of cardiovascular death in patients with nonvalvular atrial fibrillation (NVAF), reports a recent study.
Long-term combination therapy with relugolix plus oestradiol and norethindrone (relugolix-CT) shows sustained reductions in dysmenorrhoea and non-menstrual pelvic pain (NMPP) for up to 2 years in premenopausal women with endometriosis, according to the SPIRIT extension* study presented at ESHRE 2022.
Special Reports
In this third interview of a series focused on dengue, Dr Ravindran Thayan, Head of Virology Unit at Institute for Medical Research, discussed the reasons for epidemic outbreaks in Malaysia, and the challenges associated with dengue surveillance and dengue serotypes in Malaysia.
Dry eye disease (DED) is a multifactorial condition characterized by tear film instability, and results in ocular discomfort and visual disturbance, and may impact patient’s quality of life such as reading and driving at night. The outer most lipid layer of the tear film, formed by the meibum, helps to maintain tear film stability by reducing the rate of tear evaporation. Alteration in the tear lipid layer, because of impaired quality or quantity of the meibum, is one of the most common causes of evaporative DED.
The recent Myeloproliferative Neoplasms Expert Forum: Deep Dive into ERNEST saw Professor Alessandro M. Vannucchi, professor of hematology at the University of Florence, Italy, present an analysis on the ERNEST registry and study, and the subsequent updated ERNEST study. He delved into the patient cohort, benefits in overall survival and symptoms, and answered the perennial question of whether Jakavi® (ruxolitinib) provides absolute improvements in myelofibrosis (MF) survival.
The prevalence of OA, which is the most common cause of disability in the aged population, is increasing in Malaysia owing to a combination of risk factors such as older age and obesity. A COPCORD study conducted in Malaysia found that 64.8% of all joint-related complaints were knee related; among patients assessed for knee pain, over half showed clinical evidence of OA. While the 2013 Malaysian CPG on the Management of Osteoarthritis recommends a linear step-up approach in managing knee OA, monotherapy is often inadequate in relieving pain symptoms and functional limitations experienced by patients with arthritis.
In a virtual lecture series sponsored by Viatris, Dr Dolores Bonzon spoke about the importance of blood pressure (BP) control and recommendations for pharmacologic treatment in the management of paediatric hypertension (HTN). She also discussed the diagnosis and treatment of a paediatric patient with HTN from her practice.
At the recent regional Myeloproliferative Neoplasm (MPN): New Horizons, A Cross-Country Webinar supported by Novartis, Dr Francesco Passamonti, professor of haematology, University Hospital Ospedale di Circolo, Fondazione Macchi, Varese, Italy, addressed the current landscape of treatment surrounding Myelofibrosis (MF) and improving survival outcomes.
3.9 million Malaysians have diabetes, representing a staggering 1in 5 adults. We also have the highest rate of diabetes in Asia and to compound matters, more than half of them will develop chronic kidney disease (CKD) during their lifetime. The incidence of CKD is also rising relentlessly year after year, evolving rapidly into not only a Malaysian, but a global non-communicable disease pandemic. Progressive CKD may not only lead to end-stage renal disease but markedly increases mortality risks, where this grows more than ten times fold if one happens to have CKD.
Conference Reports
Daily antibiotics are the current guideline-recommended standard for urinary tract infection (UTI). Interestingly, in the randomized, open-label ALTAR trial presented at EAU 2022, the urinary antiseptic methenamine hippurate was noninferior to antibiotic prophylaxis in women with recurrent UTI.
Ignorance and fear of HIV both contribute significantly to the negative attitudes towards men who have sex with men (MSM) living with the virus, suggests a study presented at the 24th International AIDS Conference (AIDS 2022) in Montreal, Canada.
The anti-PD-L1 antibody avelumab demonstrated clinical activity as first-line treatment for patients with metastatic or locally advanced urothelial carcinoma who were PD-L1-positive and ineligible for cisplatin, according to findings from the ARIES trial presented at EAU 2022.
The long-acting combination of cabotegravir plus rilpivirine, administered as monthly or once-every-2-months jabs, appears to be effective in both older and younger patients living with HIV, with most maintaining virologic suppression through week 96, according to pooled data from the phase III ATLAS, FLAIR, and ATLAS-2M studies.
Transgender individuals, particularly transgender men (TGM), show poor acceptance of HIV prevention interventions (HPI) in the Philippines, according to a study presented at the AIDS 2022 conference in Montreal, Canada. Although some transgender individuals who prefer having sex with men make use of HPI, it remains relatively lower among TGM who have sex with men (SM).
Co-occurring and long-term heavy drinking, smoking, and depressive symptoms are common among women living with HIV, according to a study presented at the 24th International AIDS Conference (AIDS 2022). In turn, such sustained syndemics appear to worsen mortality in this population.
Treatment with dolutegravir during pregnancy does not appear to pose an excess risk of adverse birth outcomes, according to two studies presented at the 24th International AIDS Conference in Montreal, Canada.
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