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Atogepant emerges as potential migraine prophylaxis

Roshini Claire Anthony, 3 hours ago

Atogepant, a novel oral calcitonin gene-related peptide (CGRP) receptor antagonist, has shown potential in prevention of migraine at a range of doses, according to a presentation at the recent American Headache Society conference (AHS 2019).

Urea breath test yields accurate results for H. pylori detection in Asian patients

4 hours ago

The carbon 13 urea breath test (13C-UBT) is sensitive and accurate for the diagnosis of Helicobacter pylori infection in Asians, as shown in the results of a systematic review and meta-analysis.

PDE9 inhibition improves natriuretic peptide efficacy in experimental heart failure

4 hours ago

Inhibition of phosphodiesterase-9 (PDE9-I) is associated with improved efficacy of natriuretic peptide (NP), as well as favourable haemodynamic and renal effects in experimental heart failure (HF), a recent study has shown.

Consequences of a disciplinary decision on doctors’ practice behaviour in providing H&L injection

Stephen Padilla, 5 hours ago

A doctor in Singapore has recently been fined SGD 100,000 for failing to obtain informed consent from a patient prior to an injection of hydrocortisone and lignocaine (H&L). This disciplinary action has impacted the practice behaviour of some doctors in two aspects: avoidance behaviour and change in price for a service or procedure, according to a descriptive study.

ESC hs-cTn 0/1 h better than extended algorithm in predicting MACE

6 hours ago

The European Society of Cardiology (ESC) high-sensitivity cardiac troponin (hs-cTn) measurement at presentation and after 1 h (ESC hs-cTn 0/1 h algorithm) provides a better balance of efficacy and safety when predicting major adverse cardiac events (MACE), a study has shown. On the other hand, the extended algorithm is the preferred option for the rule-out of 30-day MACE with unstable angina (UA).

Immunomodulator–anti-TNF combo cuts risk of treatment ineffectiveness in CD but not UC

Jairia Dela Cruz, 8 hours ago

Initiating therapy with a combination of immune modulators (IM) and antitumour necrosis factor (anti-TNF) agents appears to reduce the incidence of therapeutic ineffectiveness in patients with Crohn’s disease (CD) but not those with ulcerative colitis (UC), a recent study has found.

Benefits of 3rd Generation Beta-blockers in Antihypertensive Therapy

Prof. Rafael R. Castillo, Dr. Hyo Seung Ahn, 20 Aug 2019

Major trials have demonstrated the benefits of beta-blockers in the treatment of hypertension.¹At a recent symposium held during the Asian Paciﬁc Society of Cardiology 2019 Congress in Manila, Philippines, experts discussed the latest guidelines on hypertension treatment, with a focus on the role of the 3^rdgeneration beta-blocker, nebivolol. The symposium was chaired by Dr Dante D. Morales, Clinical Associate Professor at the University of the Philippines College of Medicine, and featured renowned cardiologists Prof Rafael R. Castillo and Dr Hyo Seung Ahn.

Exploring the efficacy and cost-effectiveness of influenza vaccination in the elderly

19 Aug 2019

The cost of hospitalization for complications associatedwith influenza can be reduced significantly through theprevention of influenza infection.5 Cost savings mayincrease exponentially if one considers the control ofinfluenza outbreaks, especially in the aged care homesetting.

Optimizing Treatment Adherence in Advanced Renal Cell Carcinoma: A Case Study

14 Aug 2019

Renal cell carcinoma (RCC) is the most common primary tumour arising from the kidney, constituting approximately 80–85% of primary renal neoplasms. According to the Malaysian National Cancer Registry Report 2007–2011, RCC accounts for 62.8% of all kidney cancers nationwide. RCC typically occurs approximately 50% more commonly in men compared with women, and predominantly occurs in the sixth to eighth decade of life.

Prolonged fever in children: Not always a result of the dengue virus

23 Jul 2019

In an environment where children can interact openly, highly infectious diseases, such asinfluenza, have the potential to spread among childrenand those they come in contact with. Once infected,parents or siblings may have to take time off work or school to recover and to avoid spreading the disease to other healthy individuals.

Formulations Matter: Improving CoQ10 Bioavailability with the VESIsorb® Technology

22 Jul 2019

Coenzyme Q10 (CoQ10, ubiquinone) is a fat-soluble, potent physiological antioxidant that is required for the production of cellular adenosine triphosphate (ATP). CoQ10 can be obtained through tissue synthesis and diet, and it has been widely studied in patients with cardiovascular (CV) risk factors. The effects of oral CoQ10 supplementation in different patient subgroups are presented here.

PyloBalance as an adjunct therapy in the treatment of H. pylori infections

17 Jul 2019

All Helicobacters are urease-positive, able to convert aminoacids and urea into ammonia to neutralize stomach acid, andhighly mobile – characteristics that help them invade the mucosallayer to evade the body’s immune response. Helicobacter pylori(H. pylori) is linked to peptic ulcer disease, chronic gastritis,gastric mucosa-associated lymphoid tissue lymphoma, andearly gastric cancer. The infection rate of H. pylori is over 80% indeveloping countries and 20–50% in industrialized nations, withover 4.4 billion people testing positive for the bacteria in 2015.1,2

Advances in the treatment for T2DM: Improving outcomes with empagliflozin/linagliptin combination therapy

15 Jul 2019

Type 2 diabetes mellitus (T2DM) is on the rise owing to the increasing prevalence of obesity and sedentary lifestyles. As such, when considering treatment for patients who are overweight or obese, clinicians should be aware of potential weight gain that is associated with antidiabetic medication.

Dolutegravir-emtricitabine + TAF/TDF combo ADVANCEs as potential HIV-1 treatment

Roshini Claire Anthony, 20 Aug 2019

The combination of emtricitabine and dolutegravir with either a tenofovir alafenamide fumarate (TAF) or tenofovir disoproxil fumarate (TDF)-based regimen fared similarly to a TDF-emtricitabine-efavirenz regimen in reducing HIV-1 RNA levels, according to results of the phase III ADVANCE* study presented at IAS 2019.

Fostemsavir shows sustained virologic suppression in resistant HIV

Pearl Toh, 19 Aug 2019

The investigational first-in-class attachment inhibitor prodrug fostemsavir (FTR) continues to improve virologic and immunologic response from weeks 48 to 96 in patients with multidrug-resistant HIV-1 who had been heavily treated, according to the BRIGHTE* study presented at IAS 2019.

OnabotulinumtoxinA a step FORWARD in preventing chronic migraine

Roshini Claire Anthony, 16 Aug 2019

Patients receiving topiramate to prevent chronic migraines could potentially switch to onabotulinumtoxinA injections to reduce the frequency of their headaches, according to results of the FORWARD* study presented at the recent American Headache Society conference (AHS 2019).

Fremanezumab reduces migraine days

Elaine Soliven, 16 Aug 2019

Fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, significantly reduces the number of migraine days in patients with chronic migraine (CM) or episodic migraine (EM), according to the FOCUS* study presented at AHS 2019.

Two to TANGO: Dolutegravir-lamivudine combo safe, effective substitute for TAF regimen

Roshini Claire Anthony, 15 Aug 2019

Individuals with HIV-1 who demonstrate virologic suppression on a tenofovir alafenamide fumarate (TAF)-based three- or four-drug regimen (TBR) could safely switch to a two-drug regimen comprising dolutegravir and lamivudine, according to results from the phase III TANGO* study presented at the recent International AIDS Society conference (IAS 2019).

Active lifestyle may delay Alzheimer’s disease progression

Roshini Claire Anthony, 13 Aug 2019

An active lifestyle, regardless of vascular risk, may delay the progression of Alzheimer’s disease (AD) by slowing down cognitive decline and neurodegeneration, according to a study presented at the Alzheimer’s Association International Conference (AAIC 2019).

Yoga for migraine: Does it work?

Pearl Toh, 08 Aug 2019

Incorporating yoga as a complementary therapy to standard pharmacological treatment of migraine helps reduce the frequency and intensity of migraine and its impact on the lives of people with such condition, according to the CONTAIN* study presented at the 2019 AHS Meeting.

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