Multidisciplinary

Top Medical News
an hour ago
Levels of the C1q tumour necrosis factor-related protein 9 (CTRP9) adipokine correlate significantly and independently with cardiac autonomic neuropathy (CAN) in diabetics, a new study has shown.
2 hours ago
The glucagon-like peptide-1 receptor agonist semaglutide appears safe and effective in the treatment of patients with nonalcoholic steatohepatitis (NASH), resulting in a higher rate of resolution than placebo, according to the results of a phase II trial. There is, however, little effect on fibrosis stage.
4 hours ago
While there may be no particular survival benefit to performing revascularization on top of medical therapy, the combination does seem to reduce the risk of poor outcomes, such as fatal myocardial infarction and unplanned revascularizations and stroke, recent meta-analysis reports.
Roshini Claire Anthony, 16 hours ago

In patients newly diagnosed with immune thrombocytopenia (ITP), the first-line combination treatment of mycophenolate and corticosteroids was effective and well tolerated compared with corticosteroids alone, results of the UK-based Flight* trial showed.

16 hours ago
Bidirectional contact tracing, wherein both parent and subsequent cases of a known infected patient, could help drastically improve control of the coronavirus disease 2019 (COVID-19) pandemic, a recent study reports.
Pearl Toh, 19 hours ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Jairia Dela Cruz, 20 hours ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
Special Reports
Assoc Prof. Darren Poon, Assoc Prof. Edmund Chiong, 14 Jan 2021
Metastatic hormone-sensitive prostate cancer (mHSPC) refers to the condition whereby patients have metastatic prostate cancer and no prior hormonal therapy or androgen deprivation therapy (ADT). Typically, patients with mHSPC have been treated with ADT alone, following which, the overwhelming majority develop castration resistance over time and head towards eventual mortality. In recent years, the publication of various landmark trials has prompted dramatic changes in the mHSPC treatment landscape, and had favourably impacted overall survival (OS) in these patients. At a recent webinar, A/Prof Darren Poon, Honorary Consultant in Clinical Oncology, Hong Kong Sanatorium & Hospital, and Honorary Clinical Associate Professor, Department of Clinical Oncology, The Chinese University of Hong Kong, reviewed treatment options in mHSPC, while A/Prof Edmund Chiong, Head and Senior Consultant, Department of Urology, National University Hospital, Singapore, presented a case which was discussed by an esteemed panel of experts. This webinar was jointly organized by the Singapore Society of Oncology and the Singapore Urological Association, and supported by Astellas. 
Roshini Claire Anthony, 08 Jan 2021

Significant advancements in the treatment of acute lymphocytic leukaemia (ALL) in children have improved their outcomes. However, ALL treatment and eradication remain a major challenge in adults. In a recent webinar, two specialists from the US discussed current ALL treatment strategies and goals of future regimens.

Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Rachel Soon, 04 Jan 2021
At the recent Mylan (a Viatris company) webinar ‘Find the Missing Millions: Advanced Treatments for Hepatitis, ’panelists Prof Dr Rosmawati Mohamed, consultant gastroenterologist and hepatologist at University Malaya Medical Centre, and Prof Dr Henry Chan, director of the Chinese University of Hong Kong’s Center of Liver Health, discussed the current challenges in reducing the impact of chronic hepatitis B and C, as well as the evidence supporting new antivirals in treatment guidelines.
09 Dec 2020
In an interview, Dr Eric Lee Kim Hor, a consultant paediatrician from Pantai Hospital Kuala Lumpur, spoke on the importance of vaccination in the prevention of influenza among children, resulting in the prevention of coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in coronavirus disease (COVID-19) as well as reduction of burden on the healthcare system.
08 Dec 2020
At the Nimenrix Speaker Training Workshop webinar, Dr Amgad Gamil of Pfizer Inc. discussed updates on the epidemiology of invasive meningococcal disease (IMD), while simultaneously reviewing the latest immunogenicity and safety data of the MenACWY-TT vaccine (Nimenrix®, Pfizer) in the paediatric population.
Dr. Asok Kurup, Dr. Kenneth Chan, 07 Dec 2020
The rising incidence of infections caused by multidrug-resistant (MDR) gram-negative bacteria has become a serious health threat and a major challenge for intensivists. Against a backdrop of high patient mortality and risk factors for infection in intensive care units (ICU), early adequate therapy is of paramount importance. At a recent Pfizer-sponsored symposium, Dr Asok Kurup, Infectious Disease Physician, Singapore presented the implications of MDR gram-negative infections in critically ill patients in Asia, while Dr Kenneth Chan, Respiratory Physician and Intensivist, Singapore highlighted the role of ceftazidime-avibactam (Zavicefta) and shared published real-world data on ceftazidime-avibactam. 
Conference Reports
Roshini Claire Anthony, 22 Jan 2021

In patients newly diagnosed with immune thrombocytopenia (ITP), the first-line combination treatment of mycophenolate and corticosteroids was effective and well tolerated compared with corticosteroids alone, results of the UK-based Flight* trial showed.

Pearl Toh, 22 Jan 2021
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Roshini Claire Anthony, 21 Jan 2021

The presence of isolated ulnar or “nightstick” fractures may be a sign of intimate partner violence (IPV), according to a small retrospective study presented at the 2020 Radiological Society of North America (RSNA) annual meeting.

Pearl Toh, 21 Jan 2021
The oral selective sphingosine-1-phosphate (S1P) receptor modulator ozanimod induced significant improvements in clinical remission and response, which were sustained up to 52 weeks, in patients with moderate-to-severe ulcerative colitis (UC), according to the phase III True North study presented at AIBD 2020 Congress.
Elaine Soliven, 20 Jan 2021
Screening with digital breast tomosynthesis (DBT) was associated with lower false-negative (FN) cancer rates and improved breast cancer detection compared with digital mammography, according to a study presented at RSNA 2020.
Pearl Toh, 19 Jan 2021
Updates from the SECURE-IBD* registry reveal that treatment with thiopurine, either alone or in combination with tumour necrosis factor inhibitors (TNFis), for inflammatory bowel disease (IBD) was associated with a greater risk of severe COVID-19 compared with TNFis monotherapy.
Roshini Claire Anthony, 18 Jan 2021

Roxadustat appears a promising treatment for anaemia in patients with chronic kidney disease (CKD), regardless of whether they are undergoing dialysis, according to two analyses presented at ASH 2020.

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