Multidisciplinary

Inhaled treprostinil ups exercise capacity in pulmonary hypertension

Pearl Toh, 40 minutes ago

Inhaled treprostinil significantly improves exercise capacity in terms of 6-minute walking distance (6MWD) over 16 weeks compared with placebo in patients with pulmonary hypertension associated with interstitial lung disease (ILD), according to the INCREASE trial presented at ATS 2020.

Too much white rice a bane to endocrine health in South Asia

Jairia Dela Cruz, an hour ago

Eating higher amounts of white rice raises the risk of diabetes, and this association is especially pronounced in South Asia, a study has found. Meanwhile, in other regions of the world, the risk is modest or inconsequential.

Lancet warns against ‘medical populism’ in fight against COVID-19

Stephen Padilla, 3 hours ago

Ten countries in the Asia Pacific region, with six coming from Southeast Asia (SEA), have topped the ranking of nations that successfully suppressed the novel coronavirus disease (COVID-19) pandemic, according to The Lancet COVID-19 Commission statement on the 75th session of the United Nations (UN) General Assembly.

Anxiety, depression link to aortic stiffness suggests brain–gut–vascular axis in CD

4 hours ago

The associations of anxiety, depression, and chronic inflammation with aortic pulse wave velocity (aPWV) and systolic blood pressure (SBP) indicate the first evidence of a brain–gut–vascular axis and new potential targets for treatment in patients with Crohn’s disease (CD), reveals a study.

Cold atmospheric plasma therapy improves wound healing in diabetic foot ulcers

Audrey Abella, 5 hours ago

The application of cold atmospheric plasma (CAP) therapy to diabetic foot ulcers (DFUs) led to significant acceleration of wound healing process compared with placebo treatment, the German KaltplasmaWund trial has shown.

Faster insulin aspart shows real-world efficacy for T1D

Tristan Manalac, 6 hours ago

For patients with type 1 diabetes (T1D), switching to faster insulin aspart may improve glycated haemoglobin (HbA1c), time-in-range (TIR), and time in hyperglycaemia, without posing serious hypoglycaemia risks, according to a new study.

Single-inhaler triple-therapy for COPD: When one is better than more

Audrey Abella, 21 Sep 2020

Single-inhaler triple-therapy (SITT) comprising FF/UMEC/VI* is preferred over dual therapies (DT) or multiple-inhaler (MI) TT for managing COPD**, according to data presented at ERS 2020.

Mepolizumab: Targeting eosinophils in severe asthma with precision medicine

Pearl Toh, 16 Sep 2020

Mepolizumab, a first-in-class anti-IL-5* antibody, effectively prevents asthma exacerbations in patients with severe eosinophilic asthma (SEA), according to a presentation at the ERS 2020 Congress.

Nivolumab-ipilimumab displays potential in malignant pleural mesothelioma

Roshini Claire Anthony, 24 Sep 2020

For patients with unresectable malignant pleural mesothelioma (MPM), nivolumab plus ipilimumab in the first-line setting demonstrated greater overall survival (OS) than standard-of-care (SoC) platinum chemotherapy, interim analysis of the phase III CheckMate743 trial revealed.

Empagliflozin reduces CV death, HF hospitalization in HFrEF patients

Roshini Claire Anthony, 23 Sep 2020

In patients with chronic heart failure with reduced ejection fraction (HFrEF), empagliflozin reduced the risk of cardiovascular (CV) death or heart failure hospitalization (HHF) and decline in estimated glomerular filtration rate (eGFR), results of the EMPEROR-Reduced* trial showed.

DAPA-CKD heralds a new era for dapagliflozin in kidney disease

Pearl Toh, 23 Sep 2020

Adding dapagliflozin to standard of care (SOC) significantly reduces the risk of worsening kidney function, death due to kidney or cardiovascular (CV) disease, and all-cause mortality compared with SOC alone in patients with chronic kidney disease (CKD), regardless of whether they have type 2 diabetes (T2D), reveals the DAPA-CKD* trial — showing dapagliflozin charting new territories from diabetes to the renal realm.

Brensocatib tackles exacerbations in bronchiectasis

Roshini Claire Anthony, 22 Sep 2020

Treatment with the DPP 1* inhibitor brensocatib prolonged time to exacerbation and reduced exacerbation rates in patients with non-cystic fibrosis bronchiectasis, according to the phase II WILLOW** study presented at ERS 2020.

Masitinib demonstrates potential for severe asthma

Audrey Abella, 22 Sep 2020

The first-in-class oral tyrosine kinase inhibitor (TKI) masitinib demonstrated a positive benefit-risk profile over a sustained period in patients with severe persistent asthma regardless of baseline eosinophil level, with the greatest benefit seen among those with the highest oral corticosteroid (OCS) dependency, according to data presented at ERS 2020.

Daily albumin infusion fails to reduce infection, renal dysfunction in decompensated cirrhosis

Roshini Claire Anthony, 21 Sep 2020

Daily albumin infusion to achieve serum albumin levels of ≥30 g/L did not reduce the risk of infection, renal dysfunction, or mortality in individuals with acute decompensated cirrhosis, according to results of the ATTIRE* study presented at ILC 2020.

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