Multidisciplinary

Helmet-CPAP safely improves oxygenation in pregnant women with COVID-19 respiratory failure

Tristan Manalac, 40 minutes ago

Administrating continuous positive airway pressure (CPAP) through a helmet (h-CPAP) device safely improves oxygenation in women with moderate-to-severe acute respiratory failure (ARF) due to the coronavirus disease 2019 (COVID-19), a recent study has found.

High-dose semaglutide improves glucose metabolism outcomes in overweight/obese patients with T2D

Elaine Soliven, 9 hours ago

Treatment with a higher dose of semaglutide led to significantly improved glucose metabolism outcomes in patients with overweight/obesity and type 2 diabetes (T2D) compared with a lower dose of semaglutide or placebo, according to the STEP* 2 trial presented at EASD 2021.

Durvalumab + tremelimumab + chemo: A new first-line SoC for mNSCLC?

Roshini Claire Anthony, 15 hours ago

The combination of durvalumab, tremelimumab, and chemotherapy in the first-line setting improved progression-free survival (PFS) and overall survival (OS) in patients with metastatic non-small-cell lung cancer (mNSCLC), according to results of the phase III POSEIDON trial.

Atrophic gastritis, PPI use amplify EC risk in immunocompetent patients

15 hours ago

In immunocompetent patients admitted at a community hospital, comorbidities such as advanced gastric cancer and atrophic gastritis (AG), as well as treatment with proton pump inhibitors (PPI), seem to aggravate the risk of developing oesophageal candidiasis (EC), a recent study has found.

Baricitinib prevents death in critically ill COVID-19 patients

Pearl Toh, 18 hours ago

The oral selective JAK1/2 inhibitor baricitinib significantly reduces the risk of death in critically ill COVID-19 patients who are on invasive mechanical ventilation (IMV) or ECMO*, when used in combination with standard care, according to the addendum study of the COV-BARRIER trial presented at IDWeek 2021.

Everolimus helps fight recurrent thymic neuroendocrine neoplasia

Jairia Dela Cruz, 19 hours ago

Treatment with everolimus appears to have beneficial effects on recurrent thymic neuroendocrine neoplasia (NEN), particularly well-differentiated tumours, with patients having a low Ki-67 index more likely to have a better outcome with the drug, as shown in a small study.

Rapid antigen test: Don’t let perfect be the enemy of good

Pearl Toh, 23 Oct 2021

While rapid antigen test is less sensitive than conventional nucleic acid amplification test (NAAT) such as RT-PCR* in detecting SARS-CoV-2 virus, “a test does not have to be perfect to be clinically useful,” said Professor Angela Caliendo during a session in IDWeek 2021 — echoing the maxim that perfect should not be the enemy of good in the pandemic era.

Rapid COVID-19 testing: Is it as good in kids?

Roshini Claire Anthony, 20 Oct 2021

A large retrospective study from the US, presented at IDWeek 2021, has shown that the Abbott ID NOW rapid molecular COVID-19 assay is highly sensitive and specific at detecting SARS-CoV-2 infection in a paediatric population.

A new paradigm for T2DM care in the era of SGLT-2i

01 Oct 2021

During the recent EMPIRE SUMMIT, Professor Dr Chee Kok Han discussed the importance of an early, patient-centred,multi factorial approach in managing type 2 diabetes mellitus(T2DM). Specifically, Professor Chee highlighted the role ofempagliflozin (Jardiance®, Boehringer Ingelheim) in conferring cardiorenal protection to patients with T2DM.

Early-initiation-of-Enstilar--in-managing-plaque-psoriasis-provides-better-patient-outcomes

01 Oct 2021

Psoriasis is characterised by well-circumscribed, erythematous, scaly plaques and can be categorised as eitherlocalised or generalised, depending on the severity of the disease and its impact on patients’ quality of life. The mainstay of treatment for localised disease includes topical therapy with corticosteroids, calcipotriene and coal tar products, while generalised psoriasis may require more advanced forms of treatment like phototherapy and systemic therapy. In this case study, Dr Preamala Gunabalasingam shares her clinical experience treating.2plaque psoriasis with a combined formulation of betamethasone dipropionate and calcipotriol monohydrate in a single spray foam (Enstilar® Foam, LEO Pharma).

High-dose semaglutide improves glucose metabolism outcomes in overweight/obese patients with T2D

Elaine Soliven, 27 Oct 2021

Durvalumab + tremelimumab + chemo: A new first-line SoC for mNSCLC?

Roshini Claire Anthony, 26 Oct 2021

Baricitinib prevents death in critically ill COVID-19 patients

Pearl Toh, 26 Oct 2021

Rapid antigen test: Don’t let perfect be the enemy of good

Pearl Toh, 23 Oct 2021

Health status similar between sacubitril/valsartan and ramipril recipients post-acute MI

Roshini Claire Anthony, 23 Oct 2021

Patients who receive sacubitril-valsartan after an acute myocardial infarction (MI) have a similar health status, as determined by EQ-5D visual analog scale (VAS) score, compared with those who receive ramipril, according to results of a prespecified analysis of the PARADISE-MI trial presented at HFSA 2021.

Novel JAK3 blocker: Potential to stave off balding?

Pearl Toh, 22 Oct 2021

The oral selective Janus kinase 3 (JAK3) inhibitor ritlecitinib effectively prevents hair loss in people with alopecia areata (AA) compared with placebo, according to the ALLEGRO study presented at EADV 2021.