Multidisciplinary

Top Medical News
NVR 3-778 first in class hepatitis B treatment
19 hours ago
Nearly one in three children with chronic hepatitis B (CHB) who discontinued their antiviral treatment has relapsed, a study has shown.
Novel framework sets standard for ICU physiotherapists in Singapore
Stephen Padilla, 20 hours ago
A recent study has identified 163 items of skills and knowledge that are necessary as a minimum standard for clinical practice for physiotherapists working in the intensive care unit (ICU) in Singapore.
Hair loss common after COVID-19 infection
Elvira Manzano, 20 hours ago
There appears to be an increased risk of hair loss – a phenomenon called telogen effluvium – after COVID-19 infection.
Bariatric surgery-induced improvement in HDL functionality tied to reduced inflammation
21 hours ago
Individuals who undergo Roux-en-Y gastric bypass (RYGB) show improved high-density lipoprotein (HDL) functionality, which then contributes to a decrease in adipose tissue and systemic inflammation, reports a recent study.
SES, clinical factors trump brain MRI in predicting long-term neurodevelopment in CHD infants
22 hours ago
In infants with congenital heart disease (CHD), the perioperative clinical course and socioeconomic status (SES) appear to be better predictors of long-term neurodevelopmental outcomes than conventional neonatal brain magnetic resonance imaging (MRI), a new study has found.
Add-on dupilumab reduces OCS use in patients with steroid-dependent severe asthma
Audrey Abella, 22 hours ago
In patients with chronic dependence on oral corticosteroids (OCS) for severe asthma, long-term exposure to dupilumab supports sustained reduction in OCS dosage and improvement in clinical outcomes for up to 96 weeks, according to an analysis of the phase III LIBERTY ASTHMA TRAVERSE study.
Probiotics, prebiotics, synbiotics boost metabolism in NAFLD
Tristan Manalac, 23 hours ago
Patients with nonalcoholic fatty liver disease (NAFLD) who take probiotics, prebiotics, or synbiotics (PPS) may have better energy metabolism, according to a recent study.
Special Reports
Dengue Serotype and Seroprevalence in Malaysia:
The Malaysian dengue epidemic
from the perspective of serotype
and seropre
01 Aug 2022
In this third interview of a series focused on dengue, Dr Ravindran Thayan, Head of Virology Unit at Institute for Medical Research, discussed the reasons for epidemic outbreaks in Malaysia, and the challenges associated with dengue surveillance and dengue serotypes in Malaysia.
Current Updates on Management of Dry Eye Disease
01 Aug 2022
Dry eye disease (DED) is a multifactorial condition characterized by tear film instability, and results in ocular discomfort and visual disturbance, and may impact patient’s quality of life such as reading and driving at night. The outer most lipid layer of the tear film, formed by the meibum, helps to maintain tear film stability by reducing the rate of tear evaporation. Alteration in the tear lipid layer, because of impaired quality or quantity of the meibum, is one of the most common causes of evaporative DED.
Deep Dive  Into ERNEST STUDY
01 Aug 2022
The recent Myeloproliferative Neoplasms Expert Forum: Deep Dive into ERNEST saw Professor Alessandro M. Vannucchi, professor of hematology at the University of Florence, Italy, present an analysis on the ERNEST registry and study, and the subsequent updated ERNEST study. He delved into the patient cohort, benefits in overall survival and symptoms, and answered the perennial question of whether Jakavi® (ruxolitinib) provides absolute improvements in myelofibrosis (MF) survival.
A new perspective on the management of knee osteoarthritis: Summary of a Malaysian Delphi consensus
01 Jul 2022
The prevalence of OA, which is the most common cause of disability in the aged population, is increasing in Malaysia owing to a combination of risk factors such as older age and obesity. A COPCORD study conducted in Malaysia found that 64.8% of all joint-related complaints were knee related; among patients assessed for knee pain, over half showed clinical evidence of OA. While the 2013 Malaysian CPG on the Management of Osteoarthritis recommends a linear step-up approach in managing knee OA, monotherapy is often inadequate in relieving pain symptoms and functional limitations experienced by patients with arthritis.
Managing Hypertension in Children:
Guidelines and Considerations
01 Jul 2022
In a virtual lecture series sponsored by Viatris, Dr Dolores Bonzon spoke about the importance of blood pressure (BP) control and recommendations for pharmacologic treatment in the management of paediatric hypertension (HTN). She also discussed the diagnosis and treatment of a paediatric patient with HTN from her practice.
IMPROVING MYELOFIBROSIS OUTCOMES (2022):
REGULAR MONITORING AND EARLY INTERVENTION ARE KEY
TO OPTIMISE CARE AND IMPROVE OVE
01 Jul 2022
At the recent regional Myeloproliferative Neoplasm (MPN): New Horizons, A Cross-Country Webinar supported by Novartis, Dr Francesco Passamonti, professor of haematology, University Hospital Ospedale di Circolo, Fondazione Macchi, Varese, Italy, addressed the current landscape of treatment surrounding Myelofibrosis (MF) and improving survival outcomes.
Care Delayed is Care Denied: Benefits Beyond
Glycaemic Control with a Single Pill Combination
of Empagliflozin and Linaglip
01 Jul 2022
3.9 million Malaysians have diabetes, representing a staggering 1in 5 adults. We also have the highest rate of diabetes in Asia and to compound matters, more than half of them will develop chronic kidney disease (CKD) during their lifetime. The incidence of CKD is also rising relentlessly year after year, evolving rapidly into not only a Malaysian, but a global non-communicable disease pandemic. Progressive CKD may not only lead to end-stage renal disease but markedly increases mortality risks, where this grows more than ten times fold if one happens to have CKD.
Conference Reports
Is 5-year interval sufficient for prostate cancer screening in older men?
Roshini Claire Anthony, 18 Aug 2022

Diagnosis, progression, or death due to prostate cancer occur at approximately a decade to 15 years following an initial assessment of prostate-specific antigen (PSA) levels in older men, according to a study presented at EAU 2022.

Dancing protective against AD, dementia?
Audrey Abella, 17 Aug 2022
Studies presented at AAIC 2022 show that dancing could be a protective factor against the development of Alzheimer’s disease (AD) and dementia in older adults.
Haemorrhagic complications in COVID-19 patients linked to mortality risk in ICU
Roshini Claire Anthony, 16 Aug 2022

A large global study of patients with severe COVID-19 admitted to the intensive care unit (ICU) has shown a 14 percent prevalence of haemorrhagic, coagulopathic, and thrombotic (HECTOR) complications in these patients, with mortality risk increased in those with haemorrhagic complications. 

Does TB influence viral suppression in HIV patients on DTG-based therapy?
Audrey Abella, 16 Aug 2022
Incident tuberculosis (TB) appears to be a risk factor for virologic non-suppression (ie, viral load of >1,000 copies/mL) in HIV patients who have transitioned to dolutegravir (DTG)-based therapy with recycled NRTIs*, according to a retrospective subanalysis of the VISEND study.
Short GnRH antagonist protocol in ART may reduce ovarian hyperstimulation risk
Roshini Claire Anthony, 15 Aug 2022

A large systematic review and meta-analysis of women undergoing assisted reproduction has shown that the use of short gonadotropin-releasing hormone (GnRH) antagonist protocols, compared with long GnRH agonist protocols, during controlled ovarian stimulation (COS) may reduce the risk of ovarian hyperstimulation syndrome (OHSS) while having no major impact on live birth rates. 

Subgroup analyses boost masupirdine potential for AD
Audrey Abella, 15 Aug 2022
Post hoc data from a phase II study presented at AAIC 2022 continue to demonstrate the potential of masupirdine (SUVN-502), a selective 5-HT6 receptor antagonist, as a treatment alternative for the management of neuropsychiatric and cognitive symptoms of Alzheimer’s disease (AD).
Two-fold setback: ICU stay doubles dementia risk
Elvira Manzano, 13 Aug 2022
Intensive care unit (ICU) hospitalization doubles the risk of subsequent dementia in older adults, a longitudinal study suggests.