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Top Medical News
The increasingly adopted strategy to freeze all IVF* embryos for transfer in a later cycle offers no improvement in ongoing pregnancy rates over the conventional strategy of fresh embryo transfer among normo-ovulatory women, thus calling into question a general freeze-all strategy in a growing number of clinics.
Surgery during pregnancy appears to increase the likelihood of preterm deliveries and lower birthweight infants, a new study has shown.
The likelihood of pregnancy following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is significantly reduced when male partners are aged 51 years and older, according to a retrospective study from the UK.
Surufatinib has demonstrated encouraging antitumour activity with manageable toxicity profile in patients with extrapancreatic neuroendocrine tumours (NETs), according to the results of a phase I/IIb trial.
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.
Drinking sugary beverages may increase the risks of overall cancer and breast cancer, suggests a study. Of note, 100-percent fruit juices also correlate with the risk of overall cancer.
OPTILOGG, an mHealth tool for heart failure (HF) that provides education, symptom monitoring and diuretic titration guide, effectively cuts in-hospital days and improves self-care behaviour in the general HF population, according to data from two clinical controlled trials.
Special Reports
All Helicobacters are urease-positive, able to convert aminoacids and urea into ammonia to neutralize stomach acid, andhighly mobile – characteristics that help them invade the mucosallayer to evade the body’s immune response. Helicobacter pylori(H. pylori) is linked to peptic ulcer disease, chronic gastritis,gastric mucosa-associated lymphoid tissue lymphoma, andearly gastric cancer. The infection rate of H. pylori is over 80% indeveloping countries and 20–50% in industrialized nations, withover 4.4 billion people testing positive for the bacteria in 2015.1,2
Type 2 diabetes mellitus (T2DM) is on the rise owing to the increasing prevalence of obesity and sedentary lifestyles. As such, when considering treatment for patients who are overweight or obese, clinicians should be aware of potential weight gain that is associated with antidiabetic medication.
At the 4th Respiratory Forum, jointly organized by theMalaysian Thoracic Society and Boehringer Ingelheim,two distinguished speakers addressed the use ofdual bronchodilators versus triple therapy in chronicobstructive pulmonary disease (COPD) and discussedabout updates from recent clinical trials.
At a recent Boehringer Ingelheim-sponsored symposium held in conjunction with the National Heart Association of Malaysia Congress 2019, two distinguished speakers discussed the importance of cardiovascular (CV) risk management in patients with type 2 diabetes mellitus (T2DM), and highlighted the role of sodium-glucose co-transporter-2 (SGLT-2) inhibitors in reducing the risk of adverse CV outcomes.
Acquired immunodeficiency syndrome (AIDS) remains as one of the world’s leading causes of mortality in global public health. Dr Charles Hicks shared his insights into the increasing role of dolutegravir (DTG; Tivicay, GSK) – an integrase strand transfer inhibitor (INSTI) – in HIV therapy during the 4th National AIDS Conference 2018 at Swiss Garden International Hotel and Residences, Kuala Lumpur.
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
In conjunction with TRB Chemedica’s 30th anniversary, a panel of distinguished speakers shared their insights into the management of the associated disorders surrounding dry eye disease (DED) at the HOPE Symposium.
Conference Reports
A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
The combination of TAS-118 and oxaliplatin led to significantly greater survival compared with the S-1 and cisplatin combination in patients with metastatic or recurrent HER2-negative gastric cancer, the phase III SOLAR* study showed.
Reducing the dose of regorafenib did little to affect the overall tolerability of the drug in patients with metastatic colorectal cancer (mCRC), according to the phase II REARRANGE* trial presented at ESMO GI 2019.
Women with polycystic ovarian syndrome (PCOS) undergoing assisted reproductive technology (ART) cycles may benefit from the administration of myo-inositol (MI) which improves oocyte and embryo quality due to alterations in gene expression in granulosa cells, according to a study presented at ESHRE 2019.
The survival benefit with ramucirumab was consistent in patients with advanced hepatocellular carcinoma (HCC) and high alpha-fetoprotein (AFP) levels regardless of whether they were previously treated with transarterial chemoembolization (TACE), a post hoc analysis of pooled data from the REACH/REACH-2 studies shows.
Augmenting the triple chemotherapeutic regimen FOLFOXIRI* with bevacizumab demonstrated favourable efficacy regardless of age and gender in patients with unresectable metastatic colorectal cancer (mCRC), according to data presented at the ESMO World Congress on Gastrointestinal Cancer (ESMO GI) 2019.
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