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Multidisciplinary
Top Medical News
Unrestricted access to direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection in individuals with HIV led to a substantial reduction in HCV incidence, particularly in the key subgroup of men who have sex with men (MSM), according to a retrospective Dutch study.
Cancer patients administered with prophylactic antiviral drugs are still at risk of hepatitis B virus (HBV) reactivation during chemotherapy, a Taiwan study has found.
Malnutrition and sarcopaenia are highly inter-related and have overlapping presentations in adults, according to a recent Singapore study.
The standard combination therapy against paediatric migraine—consisting of a combination of parenteral medications—appears to yield moderate pain relief, which persists up to 1 week after administration, a new study has found.
For patients with early Parkinson’s disease, engaging in physical activity helps lower anxiety and apathy scores over time, as shown in a recent study.
Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) did not result in worsening renal function or bone mineral density (BMD) in Asian patients with chronic hepatitis B virus (HBV) infection, according to a small real-world prospective study.
There appears to be a link between a mother’s age at menarche (AAM) and pubertal timing in her children, a recent China study has shown. In particular, an earlier AAM also hastens puberty, corresponding to earlier menarche in girls and first ejaculation in boys.
Special Reports
Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.
Metastatic hormone-sensitive prostate cancer (mHSPC) refers to the condition whereby patients have metastatic prostate cancer and no prior hormonal therapy or androgen deprivation therapy (ADT). Typically, patients with mHSPC have been treated with ADT alone, following which, the overwhelming majority develop castration resistance over time and head towards eventual mortality. In recent years, the publication of various landmark trials has prompted dramatic changes in the mHSPC treatment landscape, and had favourably impacted overall survival (OS) in these patients. At a recent webinar, A/Prof Darren Poon, Honorary Consultant in Clinical Oncology, Hong Kong Sanatorium & Hospital, and Honorary Clinical Associate Professor, Department of Clinical Oncology, The Chinese University of Hong Kong, reviewed treatment options in mHSPC, while A/Prof Edmund Chiong, Head and Senior Consultant, Department of Urology, National University Hospital, Singapore, presented a case which was discussed by an esteemed panel of experts. This webinar was jointly organized by the Singapore Society of Oncology and the Singapore Urological Association, and supported by Astellas.
Significant advancements in the treatment of acute lymphocytic leukaemia (ALL) in children have improved their outcomes. However, ALL treatment and eradication remain a major challenge in adults. In a recent webinar, two specialists from the US discussed current ALL treatment strategies and goals of future regimens.
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
At the recent Mylan (a Viatris company) webinar ‘Find the Missing Millions: Advanced Treatments for Hepatitis, ’panelists Prof Dr Rosmawati Mohamed, consultant gastroenterologist and hepatologist at University Malaya Medical Centre, and Prof Dr Henry Chan, director of the Chinese University of Hong Kong’s Center of Liver Health, discussed the current challenges in reducing the impact of chronic hepatitis B and C, as well as the evidence supporting new antivirals in treatment guidelines.
In an interview, Dr Eric Lee Kim Hor, a consultant paediatrician from Pantai Hospital Kuala Lumpur, spoke on the importance of vaccination in the prevention of influenza among children, resulting in the prevention of coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in coronavirus disease (COVID-19) as well as reduction of burden on the healthcare system.
At the Nimenrix Speaker Training Workshop webinar, Dr Amgad Gamil of Pfizer Inc. discussed updates on the epidemiology of invasive meningococcal disease (IMD), while simultaneously reviewing the latest immunogenicity and safety data of the MenACWY-TT vaccine (Nimenrix®, Pfizer) in the paediatric population.
Conference Reports
Using high-dose oxytocin for labour augmentation did not significantly reduce the incidence of Caesarean delivery among nulliparous women compared with standard dosing, according to a study presented at SMFM 2021.
De-adoption of the practice of swabbing the mouth with chlorhexidine for the prevention of ventilator-associated pneumonia (VAP) in the intensive care unit (ICU) and implementing a standard oral care bundle does not necessarily reduce mortality, infection-related ventilator-associated complications (IVACs), or procedural pain, according to the results of the CHORAL study.
Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.
The systemic use of corticosteroids lowers 28-day all-cause mortality among patients with the novel coronavirus disease (COVID-19), as opposed to usual care or placebo, according to the REACT* meta-analysis presented at the recently concluded eCritical Care Reviews Meeting 2021 (eCCR21).
Older maternal age and higher body mass index (BMI) were associated with an increased risk of nulliparous, term, singleton, vertex (NTSV) Caesarean delivery, according to a study presented at SMFM 2021.
The propensity of the novel coronavirus disease (COVID-19) to develop into a severe and life-threatening disease appears to be influenced by genetics, according to the GenOMICC* study, whose results were recently presented at the eCritical Care Reviews Meeting 2021 (eCCR21).
In patients with acute hypoxemic respiratory failure admitted to the intensive care unit (ICU), a lower oxygenation target does not lead to a lower mortality rate, according to results of the HOT-ICU* trial presented at eCCR 2021.
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