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Multidisciplinary
Top Medical News
Among individuals with gastro‐oesophageal reflux symptoms, those with hiatal hernia and those who consume alcohol appear to have a high prevalence of Barrett's oesophagus, as reported in a study.
Amidst the optimism from COVID-19 vaccine roll-out, the irrepressible yearning for normalcy is unmistakable. People are starting to drop their guard, thronging malls, and snapping up cruise tickets as soon they become available.
Among patients with inflammatory bowel diseases (IBDs), low-grade dysplasia, ulcerative colitis (UC; as opposed to Crohn’s disease [CD]), primary sclerosing cholangitis, and an extensive disease seem to aggravate the risk of advanced colorectal neoplasia, reports a recent meta-analysis.
Adjuvant pelvic radiotherapy shows promise in reducing the rate of distant metastases among patients with uterine carcinosarcoma (UCS), reports a study. However, it appears to offer no statistically significant improvements in survival metrics.
Treatment with paclitaxel plus ramucirumab beyond the first-line setting appears to improve overall survival (OS) among patients with metastatic gastric or lower oesophageal adenocarcinoma, results of a real-world study have shown.
Prior exposure to pain and the mere possession of an analgesic seem to affect subsequent analgesia, altering pain threshold and tolerance, a new study has found.
Most individuals using marijuana for treating nausea are likely to experience relief within a relative short duration of time, although the level of antiemetic effect is influenced by the characteristics of the products consumed, a study has found.
Special Reports
Intensive care unit (ICU) patients are at risk of developing serious infections with multidrug-resistant organisms (MDROs), which require appropriate and adequate antibiotic coverage. Early empirical coverage is pivotal in saving patients’ lives. At a recent webinar co-organized by the Society of Infectious Disease (Singapore) and Pfizer, renowned Professor David Paterson, Professor of Medicine and Director, The University of Queensland Centre for Clinical Research, and Consultant Infectious Diseases Physician, Royal Brisbane and Women’s Hospital, Brisbane, Australia, discussed the role of newer antimicrobial agents, including ceftazidime-avibactam (Zavicefta) in the management of MDROs in the ICU. Dr Wong Sin Yew, Infectious Disease Physician at Gleneagles Medical Centre and Mount Elizabeth Novena Specialist Centre, Singapore, chaired the event.
In Singapore, advanced breast cancer (aBC) is the leading cause of cancer death in women 30–49 years of age. For premenopausal women diagnosed with hormone receptor (HR)-positive, HER2-negative BC, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors provide new hope. Currently, ribociclib is the only CDK4/6 inhibitor studied in the first-line setting for premenopausal women with HR+/HER2- aBC, in the phase III MONALEESA-7 trial. Two experts, Dr Wong Seng Weng, Medical Director & Consultant Medical Oncologist at The Cancer Centre, Paragon Medical & Mount Elizabeth Novena Specialist Centre, and Dr Lee Guek Eng, Senior Consultant & Specialist in Medical Oncology at Icon Cancer Centre and Program Director of the Young Women Cancer Program, weigh in with their views on managing premenopausal women with aBC.
Chronic coronary syndrome (CCS) remains a leading cause of death and disability worldwide. The dual goals of CCS management is to prevent future cardiac events, such as myocardial infarction and death, and to reduce ischaemia and relieve angina symptoms, says Prof Peter Yan, consultant cardiologist and medical director, Peter Yan Cardiology Clinic, Gleneagles Medical Centre, Singapore, during a Servier-sponsored virtual symposium.
SALOFALK – Mesalazine 1.5 g PR granules
During a recent GSK webinar, Professor Norbert Berend and Dr Gur Levy discussed the principles of asthma management and its applications, specifically addressing and challenging the use of maintenance and reliever therapy (MART). Additionally, they also highlighted recent updates on the budesonide/formoterol PRN regimen.
Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.
Metastatic hormone-sensitive prostate cancer (mHSPC) refers to the condition whereby patients have metastatic prostate cancer and no prior hormonal therapy or androgen deprivation therapy (ADT). Typically, patients with mHSPC have been treated with ADT alone, following which, the overwhelming majority develop castration resistance over time and head towards eventual mortality. In recent years, the publication of various landmark trials has prompted dramatic changes in the mHSPC treatment landscape, and had favourably impacted overall survival (OS) in these patients. At a recent webinar, A/Prof Darren Poon, Honorary Consultant in Clinical Oncology, Hong Kong Sanatorium & Hospital, and Honorary Clinical Associate Professor, Department of Clinical Oncology, The Chinese University of Hong Kong, reviewed treatment options in mHSPC, while A/Prof Edmund Chiong, Head and Senior Consultant, Department of Urology, National University Hospital, Singapore, presented a case which was discussed by an esteemed panel of experts. This webinar was jointly organized by the Singapore Society of Oncology and the Singapore Urological Association, and supported by Astellas.
Conference Reports
New evidence from a recent trial points to a genetically defined male equivalent of PCOS* that is characterized by ovarian-independent pathogenesis and can increase risks for excess weight, type 2 diabetes (T2D), and cardiovascular disease (CVD) in men, reports an expert at ENDO 2021.
Select stroke patients who present late to the hospital — beyond 6 hours and up to 24 hours after stroke onset — still stand to benefit from endovascular thrombectomy, confirms the AURORA meta-analysis of six randomized trials presented at the ISC 2021 Meeting.
Patients and healthcare practitioners in the endocrinology setting seem satisfied with the use of telemedicine, and most say that they would want to maintain such a system even after the novel coronavirus disease (COVID-19) pandemic, according to a study presented at the recently concluded ENDO 2021 virtual conference by the Endocrine Society.
In patients hospitalized with COVID-19, hypernatraemia during hospitalization may increase mortality risk, while hyponatraemia at admission may up the need for ventilation support, a recent study from the UK showed.
Administering recombinant human insulin-like growth hormone-1 (rhIGF-1) for 6 months followed by risedronate for another 6 months helps improve bone mineral density (BMD) at the spine in women with anorexia nervosa, according to a study.
The combination of long-acting amylin analogue AM833 (at all tested doses) and glucagon-like peptide-1 receptor agonist semaglutide (2.4 mg) is well tolerated and shows an acceptable safety profile, with pharmacokinetics data supporting once-weekly dosing, according to a study presented at the virtual conference of the Endocrine Society (ENDO 2021).
An increase in incidence or severity of ischaemic strokes was associated with an increased risk of developing dementia, according to the ARIC* study presented at ISC 2021.
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