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Multidisciplinary
Top Medical News
In patients hospitalized with COVID-19, hypernatraemia during hospitalization may increase mortality risk, while hyponatraemia at admission may up the need for ventilation support, a recent study from the UK showed.
Obstructive sleep apnoea (OSA) is common among postmenopausal women with breast cancer or endometrial cancer, a recent study has found.
Administering recombinant human insulin-like growth hormone-1 (rhIGF-1) for 6 months followed by risedronate for another 6 months helps improve bone mineral density (BMD) at the spine in women with anorexia nervosa, according to a study.
The overall rate of meningitis is low among patients with inflammatory bowel disease (IBD), but they remain at increased risk than their non-IBD counterparts, according to a study.
The combination of long-acting amylin analogue AM833 (at all tested doses) and glucagon-like peptide-1 receptor agonist semaglutide (2.4 mg) is well tolerated and shows an acceptable safety profile, with pharmacokinetics data supporting once-weekly dosing, according to a study presented at the virtual conference of the Endocrine Society (ENDO 2021).
Rising pollen count appears to trigger flares of urological chronic pelvic pain syndrome, suggests a study.
Genetic risk factors of polycystic ovary syndrome (PCOS) also induce a similar condition in men, suggesting that PCOS is not always and necessarily a disorder of women’s reproductive systems, according to a new study presented at the recently concluded ENDO 2021 virtual conference by the Endocrine Society.
Special Reports
Intensive care unit (ICU) patients are at risk of developing serious infections with multidrug-resistant organisms (MDROs), which require appropriate and adequate antibiotic coverage. Early empirical coverage is pivotal in saving patients’ lives. At a recent webinar co-organized by the Society of Infectious Disease (Singapore) and Pfizer, renowned Professor David Paterson, Professor of Medicine and Director, The University of Queensland Centre for Clinical Research, and Consultant Infectious Diseases Physician, Royal Brisbane and Women’s Hospital, Brisbane, Australia, discussed the role of newer antimicrobial agents, including ceftazidime-avibactam (Zavicefta) in the management of MDROs in the ICU. Dr Wong Sin Yew, Infectious Disease Physician at Gleneagles Medical Centre and Mount Elizabeth Novena Specialist Centre, Singapore, chaired the event.
In Singapore, advanced breast cancer (aBC) is the leading cause of cancer death in women 30–49 years of age. For premenopausal women diagnosed with hormone receptor (HR)-positive, HER2-negative BC, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors provide new hope. Currently, ribociclib is the only CDK4/6 inhibitor studied in the first-line setting for premenopausal women with HR+/HER2- aBC, in the phase III MONALEESA-7 trial. Two experts, Dr Wong Seng Weng, Medical Director & Consultant Medical Oncologist at The Cancer Centre, Paragon Medical & Mount Elizabeth Novena Specialist Centre, and Dr Lee Guek Eng, Senior Consultant & Specialist in Medical Oncology at Icon Cancer Centre and Program Director of the Young Women Cancer Program, weigh in with their views on managing premenopausal women with aBC.
Chronic coronary syndrome (CCS) remains a leading cause of death and disability worldwide. The dual goals of CCS management is to prevent future cardiac events, such as myocardial infarction and death, and to reduce ischaemia and relieve angina symptoms, says Prof Peter Yan, consultant cardiologist and medical director, Peter Yan Cardiology Clinic, Gleneagles Medical Centre, Singapore, during a Servier-sponsored virtual symposium.
SALOFALK – Mesalazine 1.5 g PR granules
During a recent GSK webinar, Professor Norbert Berend and Dr Gur Levy discussed the principles of asthma management and its applications, specifically addressing and challenging the use of maintenance and reliever therapy (MART). Additionally, they also highlighted recent updates on the budesonide/formoterol PRN regimen.
Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.
Metastatic hormone-sensitive prostate cancer (mHSPC) refers to the condition whereby patients have metastatic prostate cancer and no prior hormonal therapy or androgen deprivation therapy (ADT). Typically, patients with mHSPC have been treated with ADT alone, following which, the overwhelming majority develop castration resistance over time and head towards eventual mortality. In recent years, the publication of various landmark trials has prompted dramatic changes in the mHSPC treatment landscape, and had favourably impacted overall survival (OS) in these patients. At a recent webinar, A/Prof Darren Poon, Honorary Consultant in Clinical Oncology, Hong Kong Sanatorium & Hospital, and Honorary Clinical Associate Professor, Department of Clinical Oncology, The Chinese University of Hong Kong, reviewed treatment options in mHSPC, while A/Prof Edmund Chiong, Head and Senior Consultant, Department of Urology, National University Hospital, Singapore, presented a case which was discussed by an esteemed panel of experts. This webinar was jointly organized by the Singapore Society of Oncology and the Singapore Urological Association, and supported by Astellas.
Conference Reports
In patients hospitalized with COVID-19, hypernatraemia during hospitalization may increase mortality risk, while hyponatraemia at admission may up the need for ventilation support, a recent study from the UK showed.
Administering recombinant human insulin-like growth hormone-1 (rhIGF-1) for 6 months followed by risedronate for another 6 months helps improve bone mineral density (BMD) at the spine in women with anorexia nervosa, according to a study.
The combination of long-acting amylin analogue AM833 (at all tested doses) and glucagon-like peptide-1 receptor agonist semaglutide (2.4 mg) is well tolerated and shows an acceptable safety profile, with pharmacokinetics data supporting once-weekly dosing, according to a study presented at the virtual conference of the Endocrine Society (ENDO 2021).
Genetic risk factors of polycystic ovary syndrome (PCOS) also induce a similar condition in men, suggesting that PCOS is not always and necessarily a disorder of women’s reproductive systems, according to a new study presented at the recently concluded ENDO 2021 virtual conference by the Endocrine Society.
Getting patients with suspected large-vessel occlusion (LVO) stroke to undergo immediate angiography instead of the standard CT scan speeds up time stroke treatment and improves 90-day functional outcomes, according to the ANGIOCAT study presented at the ISC 2021 Meeting.
Using 17α-hydroxyprogesterone caproate (17-OHPC) to treat habitual and threatened abortion in pregnant women poses an increased future risk of cancer among their children, according to a study.
Metformin reduces mortality in diabetic patients with COVID-19
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