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Changes in weight and waist circumference appear to have a dose-response association with the risk of future breast cancer, such that the greater the gain, the higher the risk, according to a retrospective study.
Adherence to a Mediterranean-style diet and higher intake of total carotenoid help prevent frailty over time, according to a study. This benefit is more pronounced in adults aged <60 years.
Results of the STOP-COVID trial, presented at ERS 2022, showed no clinical outcome benefit with the dipeptidyl peptidase-1 (DPP-1) inhibitor brensocatib compared with placebo in patients hospitalized with COVID-19 in the UK.
Use of proton pump inhibitors (PPIs) helps prevent upper gastrointestinal (GI) bleeding in patients using oral anticoagulants, reveals a study.
In neovascular age-related macular degeneration (nAMD), the absence of exudative recurrence after three loading doses of antivascular endothelial growth factor (VEGF) is associated with younger age, smaller lesion size, and having no fibrovascular pigment epithelial detachment (PED), a recent study has found.
Patients suffering from treatment-resistant depression (TRD) have higher healthcare resource utilization (HRU) associated with psychiatric services, reports a recent study.
People suffering from plantar heel pain (PHP) have worse generic and foot-specific health-related quality of life (HRQoL), a recent study has found.
Special Reports
Multiple myeloma (MM) is an uncommon cancer usually afflicting those in their 70s. About 85% of these patients present with bone pain. When presenting to an orthopaedic surgeon, patients usually complain about back pain or bone pain. To differentiate between MM and regular bone pain, three criteria are looked at: the characteristic of the pain—MM-associated pain is persistent even with rest and can sometimes disturb sleep; the site of the pain—usually very generalized and covers entire back; and the patient’s general outlook—MM patients can look extremely unwell and complain of lethargy, loss of appetite, weight loss, and complain of feeling unwell in general.
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
A study on Systane® COMPLETE was conducted from March to April 2020. Twenty-six patients were enrolled at the beginning of the study, but only 21 patients completed the study at 1-month follow-up. The data was analysed only for those who completed the 4-week review during the study period. Systane® COMPLETE was initiated at four to six times per day, instilled into both eyes as a single therapy for dry eyes
Adalimumab soln for inj 40 mg/0.8 mL
Ravidasvir 200 mg tab
Talazoparib 0.25 mg hard cap
Patients with rare genetic diseases usually have limited treatment options if any is available. Gene therapy has been progressing tremendously especially in the treatment of challenging rare genetic diseases such as spinal muscularatrophy (SMA). Modification of genetic diseases perhaps to the point of cure may be possible with gene therapy. Two renowned experts in clinical genetics discuss gene therapies for selected deleterious genetic diseases
Conference Reports
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
Following negative primary results, the final follow-up of the SYMPLICITY HTN-3 trial takes a turn for the better, demonstrating significant blood pressure (BP) reductions with renal denervation (RDN) in patients with uncontrolled hypertension (HTN).
Timing of antihypertensive medication intake, be it in the morning or evening, does not appear to affect the risk of cardiovascular death or hospitalization for non-fatal myocardial infarction (MI) or non-fatal stroke, according to results of the TIME trial presented at ESC 2022.
In the 24-month follow-up results of the EMPROVE trial, treatment with the Spiration Valve System (SVS) endobronchial valve provided a sustained clinically significant benefit in disease-specific health-related quality of life (QoL) in patients with severe heterogeneous emphysema.
The risk of hypertensive disorders in pregnancy (HDP) is increased following assisted reproductive technology (ART) using frozen embryo transfer (FET) compared with after fresh embryo transfer or natural conception, according to results of a study presented at ESHRE 2022.
Compared with aspirin alone, treatment with a P2Y12 inhibitor (clopidogrel or ticagrelor) is associated with lower risks of cardiovascular (CV) death, myocardial infarction (MI), or stroke in patients with established coronary artery disease (CAD), according to the PANTHER* trial presented at ESC 2022.
Rocatinlimab improved disease severity in patients with moderate-to-severe head and neck atopic dermatitis (H&N AD), a post hoc analysis of a phase IIb trial has shown.
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