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Erenumab proves to be effective at lowering the number of monthly migraine days in Asian patients with chronic migraine while having a favourable safety profile, according to the results of DRAGON study.
Use of long-pulsed neodymium-doped yttrium-aluminium-garnet (LP-Nd:YAG) laser provides similar overall therapeutic effects to those of cryotherapy, results of a recent study have shown. However, laser appears more effective against recalcitrant warts and results in shorter time to warts clearance.
Weekly somapacitan is noninferior to daily growth hormone (GH) in terms of height velocity (HV), with comparable safety and mean insulin-like growth factor-1 standard deviation score (IGF-1 SDS) levels in treatment-naïve children with growth hormone deficiency (GHD), a study has shown.
Low intake of dietary choline may increase the risk of incident dementia and Alzheimer’s disease (AD), a recent study has found.
In children and adolescents with obesity, keeping healthy diets and adhering to positive dietary behaviours appear to lead to better metabolic outcomes, according to a recent Singapore study.
There appears to be no longitudinal association between hair cortisol and cortisone levels with dementia and various measures of cognitive function, a recent study has found.
Itraconazole appears to be effective in the treatment of patients with tinea corporis/cruris (TCC) or ringworm of the body, as shown in a study. However, the treatment duration needs to be longer and, even with successful treatment, many patients experience relapse.
Special Reports
Studies have shown that controlled ovarian stimulation (COS) supplementation with human chorionic gonadotropin (hCG)-driven luteinising hormone activity such as highly purified human menopausal gonadotropin (HP-hMG) (Menopur®) resulted in a significantly higher proportion of top-quality embryos and numbers of good-quality blastocysts compared with recombinant follicle-stimulating hormone (rFSH) alone. Regimens that combine FSH and hMG are often referred to as ‘mixed protocols’ and have been widely used for ovarian stimulation in the past decade. This single-centre, retrospective case series study aims to assess the efficacy of COS with follitropin delta in a mixed protocol regimen with HP-hMG in terms of the number of top-quality embryos and clinical pregnancy rate among Malaysian patients in a reproductive medicine clinic.
Managing infections in patients with multiple myeloma (MM)is important to improve their quality of life. Patients with MM are prone to infections due to the disease itself—the production of many malignant clonal plasma cells, which in turn, produce defective monoclonal antibodies.
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In conjunction with World Asthma Day and launch ofmepolizumab, GSK organised a webinar for healthcare professionals titled “The Right Patients at the Right Time: Elevating Care for SEA Patients with Biologics". Associate Professor Dr Mariko Koh Siyue, Senior Consultant in Respiratory and Critical Care Medicine, briefed the audience on severe eosinophilic asthma and discussed two case studies.
Multiple myeloma (MM) is a form of cancer where abnormal plasma cells, a type of white blood cell, accumulate in the bone marrow and replace the normal, healthy cells. While healthy plasma cells produce antibodies, cancerous plasma cells produce abnormal proteins, and the by-products of these proteins cause complications. New treatment options have transformed MM from an acute disease with a median survival of <6 months to a chronic condition where patients have better survival and quality of life (QOL).
The recent ATTR-ACT long-term extension (LTE) study concluded that patients initially treated with tafamidis had significantly better survival than those initially treated with placebo, highlighting the significance of early diagnosis and treatment in transthyretin amyloid cardiomyopathy (ATTR-CM).
At the recent 19th Malaysian Society of Haematology Scientific Meeting 2022, Professor Dr Martin Griesshammer presented an overview of the current paradigm surrounding myelofibrosis (MF) treatment and evidence that points to earlier initiation with JAK inhibition being beneficial for intermediate-1 patients.
While Viatris is a relatively new name among the pharmaceutical players, it is by no means a newcomer. The company is the result of the merger between Mylan and Upjohn, a legacy division of Pfizer. With the experience and brand legacy of two iconic powerhouses, Viatris is well-equipped to tackle the future. MIMS Doctor speaks to Jeff Bote, country manager of Viatris Malaysia, and learns a little about their direction and aspirations for the future.
Conference Reports
Oral midodrine may be a good alternative to intravenous albumin for preventing paracentesis-induced circulatory dysfunction (PICD) in patients with acute-on-chronic liver failure (ACLF) undergoing modest-volume paracentesis for ascites, suggests a new study.
A smoking cessation intervention, introduced as part of lung health screening, may encourage quitting in about 30 percent of smokers, results of the UK-based YESS* trial showed.
Patients with ST-elevation myocardial infarction (STEMI) who undergo primary percutaneous coronary intervention (PCI) have a reduced risk of all-cause death or BARC* type 3–5 bleeding when they receive a bolus plus post-PCI high-dose infusion of bivalirudin compared with heparin monotherapy, results of the BRIGHT**-4 trial showed.
In a broad range of patients with HFrEF* and iron deficiency, the administration of IV ferric derisomaltose (FDI) was associated with a lower risk of recurrent hospitalization for heart failure (HHF) and cardiovascular (CV) death compared with standard of care (SoC), findings from the IRONMAN** trial have shown.
Tongxinluo, added to guideline-directed therapy, improves outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) in the large, multicentre CTS-AMI* study. But experts are clamouring for more evidence of efficacy.
Fruquintinib, a highly selective and potent oral tyrosine kinase inhibitor of VEGFR*-1, -2, and -3, significantly improves overall survival (OS) in heavily pretreated patients with metastatic colorectal cancer (mCRC), according to the FRESCO-2** trial presented at ESMO 2022.
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