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Multidisciplinary
Top Medical News
Consumption of oily fish and use of fish oil supplements help lower the risk of developing type 2 diabetes (T2D), a study has found.
Treatment with ultra-short-acting β-blockers, such as esmolol and landiolol, in sepsis and septic shock patients with persistent tachycardia leads to a significantly lower mortality at 28 days despite initial resuscitation, according to the results of a systematic review and meta-analysis.
People who were deprived of sleep (≤4 hours per night) or who slept excessively (≥10 hours per night) saw a faster cognitive decline than those with normal sleep duration (7 hours per night), shows a large cohort study.
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.
Exercise interventions based on aerobic, combined, or isometric workout help improve pulse wave velocity (PWV) in adults with hypertension, results of a meta-analysis have shown.
Concomitant pathology of aortic stenosis (AS) and cardiac amyloidosis (CA) occurs frequently in older AS patients and has worse clinical presentation and prognosis unless treated, suggests a study. Hence, transcatheter aortic valve replacement (TAVR) must not be denied in AS-CA patients.
Left atrial volume index (LAVI) can be used as a reliable and accurate predictor of atrial fibrillation (AF) recurrence after the pulmonary vain isolation through cryo-ablation, a new study has shown.
Special Reports
Metastatic hormone-sensitive prostate cancer (mHSPC) refers to the condition whereby patients have metastatic prostate cancer and no prior hormonal therapy or androgen deprivation therapy (ADT). Typically, patients with mHSPC have been treated with ADT alone, following which, the overwhelming majority develop castration resistance over time and head towards eventual mortality. In recent years, the publication of various landmark trials has prompted dramatic changes in the mHSPC treatment landscape, and had favourably impacted overall survival (OS) in these patients. At a recent webinar, A/Prof Darren Poon, Honorary Consultant in Clinical Oncology, Hong Kong Sanatorium & Hospital, and Honorary Clinical Associate Professor, Department of Clinical Oncology, The Chinese University of Hong Kong, reviewed treatment options in mHSPC, while A/Prof Edmund Chiong, Head and Senior Consultant, Department of Urology, National University Hospital, Singapore, presented a case which was discussed by an esteemed panel of experts. This webinar was jointly organized by the Singapore Society of Oncology and the Singapore Urological Association, and supported by Astellas.
Significant advancements in the treatment of acute lymphocytic leukaemia (ALL) in children have improved their outcomes. However, ALL treatment and eradication remain a major challenge in adults. In a recent webinar, two specialists from the US discussed current ALL treatment strategies and goals of future regimens.
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
At the recent Mylan (a Viatris company) webinar ‘Find the Missing Millions: Advanced Treatments for Hepatitis, ’panelists Prof Dr Rosmawati Mohamed, consultant gastroenterologist and hepatologist at University Malaya Medical Centre, and Prof Dr Henry Chan, director of the Chinese University of Hong Kong’s Center of Liver Health, discussed the current challenges in reducing the impact of chronic hepatitis B and C, as well as the evidence supporting new antivirals in treatment guidelines.
In an interview, Dr Eric Lee Kim Hor, a consultant paediatrician from Pantai Hospital Kuala Lumpur, spoke on the importance of vaccination in the prevention of influenza among children, resulting in the prevention of coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in coronavirus disease (COVID-19) as well as reduction of burden on the healthcare system.
At the Nimenrix Speaker Training Workshop webinar, Dr Amgad Gamil of Pfizer Inc. discussed updates on the epidemiology of invasive meningococcal disease (IMD), while simultaneously reviewing the latest immunogenicity and safety data of the MenACWY-TT vaccine (Nimenrix®, Pfizer) in the paediatric population.
The rising incidence
of infections caused by multidrug-resistant (MDR) gram-negative bacteria has become
a serious health threat and a major challenge for intensivists. Against a backdrop
of high patient mortality and risk factors for infection in intensive care units
(ICU), early adequate therapy is of paramount importance. At a recent Pfizer-sponsored
symposium, Dr Asok Kurup, Infectious Disease Physician, Singapore presented the
implications of MDR gram-negative infections in critically ill patients in Asia,
while Dr Kenneth Chan, Respiratory Physician and Intensivist, Singapore highlighted
the role of ceftazidime-avibactam (Zavicefta) and shared published real-world data
on ceftazidime-avibactam.
Conference Reports
An anticoagulation strategy based on blood D-dimer level as a biomarker for clotting risk may help improve survival of patients hospitalized with COVID-19, according to a study presented during the ASH 2020 Meeting.
Dabigatran was similarly effective as standard of care (SOC) in resolving thrombus and preventing recurrent venous thromboembolism (VTE), without raising the risk of bleeding in children, according to the DIVERSITY trial presented at ASH 2020 — thus providing a potential oral alternative to standard of care for the paediatric population.
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.
A single polypill combining a beta blocker, ACE* inhibitor, statin, and diuretic, in addition to a daily dose of aspirin, significantly reduced the risk of cardiovascular disease (CVD) in patients with intermediate CV risk, according to the TIPS**-3 study presented at the AHA 2020 Scientific Sessions.
While breast cancer survivors of childbearing age are less likely to get pregnant than the general population, most of them who do become pregnant deliver healthy babies without detrimental outcomes on their long-term survival, according to a large meta-analysis presented at the SABCS 2020 Congress.
Removal of the gallbladder (ie, cholecystectomy) is not recommended at the time of intestinal resection among individuals with inflammatory bowel disease (IBD), according to data presented at AIBD 2020.
The combination of panobinostat, dexamethasone, and subcutaneous (SC) bortezomib shows promising responses in patients with relapsed or relapsed and refractory multiple myeloma (RRMM), according to the phase II PANORAMA 3* study. Furthermore, SC bortezomib may be preferable to the intravenous (IV) option for reducing toxicity.
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