Multidisciplinary

Top Medical News
Male sex, obesity among risk factors for severe COVID-19 in children
Roshini Claire Anthony, an hour ago

A large study by the US National COVID Cohort Collaborative (N3C) has identified factors associated with the risk of severe disease among children with SARS-CoV-2 infection as well as factors tied to an increased risk of multisystem inflammatory syndrome in children (MIS-C) as compared to acute COVID-19.

Salt iodination insufficient to boost iodine status in pregnant women
an hour ago
Despite policy advancement and nutritional monitoring, salt iodination seems to be an insufficient measure to provide the adequate level of iodine to pregnant women, reports a recent meta-analysis.
Antidepressant exposure in pregnancy not a risk factor for neonatal seizures, epilepsy
Jairia Dela Cruz, 5 hours ago
In pregnant women, the use of serotonergic antidepressants does not appear to put babies at risk of developing seizures or epilepsy, as reported in a study.
Even mild physical activity can cut fracture risk in older women
6 hours ago
Moderate physical activity (PA) appears to help in reducing the risk of hyperuricaemia, according to a study in a multiethnic Chinese population. In addition, decreasing sedentary time (ST) appears to be more beneficial in women than in men.
Infliximab does not contribute to long-term weight gain in IBD patients
Stephen Padilla, 7 hours ago
Treatment with infliximab does not lead to a general long-term weight gain in patients with inflammatory bowel disease (IBD), claims a study.
Carotid IDR, peak systolic velocity tied to neurological severe ischaemic events in Takayasu arteritis
8 hours ago
In patients with Takayasu arteritis, calculating the carotid intima-media thickness (IMT)/diameter ratio (IDR) and peak systolic velocity (PSV) may be useful in identifying neurological severe ischaemic events (SIEs), suggests a study.
cancer, leukemia, pathogen, WHO, bacteria, DNA origami
Tristan Manalac, 10 hours ago
For young adults with relapsed/refractory acute lymphoblastic leukaemia (R/R ALL) who had failed at least two prior lines of therapies, tisagenlecleucel appears to be an inexpensive treatment option, according to a recent Singapore study.
Special Reports
Recognising inflammatory back pain and
axial spondyloarthritis: A practical referral
algorithm for primary care physicians
18 May 2022
Early identification and referral of patients with inflammatory back pain (IBP) to rheumatologists for further assessment is imperative in ensuring those with axial spondyloarthritis (axSpA) receive timely intervention. In this interview, Associate Professor Dr Fariz Yahya shared his insights into the development, use and importance of the primary care physician-targeted IBP referral algorithm, which had been published in Malaysian Family Physician 
Psoriasis is more than skin deep
01 May 2022
Psoriasis (PsO) is a lifelong, systemic inflammatory disease associated with multiple comorbidities that extends beyond just the surface of the skin.1 Recently, MIMS Doctor spoke to Dr Bong Jan Ling, a Consultant Dermatologist at Sunway Medical Centre to gather her thoughts on the current treatment landscape of PsO, specifically the risk factors of developing psoriatic arthritis (PsA), a condition closely related to PsO, and how the coronavirus disease 2019 (COVID-19) pandemic may have impacted the management of PsO. 
Aiming for Best Outcomes: Optimizing
Myelofibrosis Treatment and Management
01 May 2022
At the recent Malaysia MPN Expert Forum, Dr Harry Gill, Clinical Assistant Professor at the University of Hong Kong, presented a review of the current treatment landscape in myelofibrosis (MF), along with a detailed look at the optimization of Jakavi® (ruxolitinib), Novartis in MF management. The forum was organized in collaboration between Novartis and the Malaysian Society of Haematology (MSH).
Empagliflozin/linagliptin combination therapy:
The way forward in the joint management of
diabetes and cardiovascular disea
01 Apr 2022
Cardiovascular disease (CVD) is a common comorbidity in diabetes mellitus (DM) and its prevalence is on the rise. Studies have reported that several factors including oxidative stress, low-grade inflammation, endothelial dysfunction and autonomic neuropathy are often present in patients with DM, and may directly contribute to the increased prevalence of myocardial infarction (MI), coronary revascularisation, stroke and congestive heart failure (HF).1,2 The presence of both DM and CVD in patients increases the risk of mortality and morbidity among men and women alike.
Management of recurrent implantation failure during the COVID-19 pandemic
Dr. Ameet Patki, Dr. Prakash Mayandi, 22 Mar 2022
Recurrent implantation failure (RIF) refers to the failure to achieve a clinical pregnancy after three in vitro fertilization (IVF) attempts with at least four good-quality embryos. RIF leaves couples frustrated and desperate for answers and is challenging for clinicians to handle, compounded by the impact of the COVID-19 pandemic restrictions. Two experts, Dr Ameet Patki, Medical Director of Fertility Associates Mumbai and Hon Assoc Prof at KJ Somaiya Medical College & Hospital, India, and Dr Prakash Mayandi, Metro IVF Fertility Centre, Kuala Lumpur, Malaysia, weigh in with their views on managing RIF during the COVID-19 pandemic.
Product Highlight - Pontevia
16 Mar 2022
Galcanezumab Injection
Conference Reports
Once-daily, low-dose elagolix reduces HMB in premenopausal women with uterine fibroids
Elaine Soliven, 20 May 2022
Once-daily (QD) administration of low-dose elagolix 150 mg led to significantly reduced heavy menstrual bleeding (HMB) in premenopausal women with uterine fibroids, according to a study presented at ACOG 2022.
Sustained benefits with ocrelizumab in relapsing-remitting MS
Roshini Claire Anthony, 19 May 2022

Patients with relapsing-remitting multiple sclerosis (RRMS) who have suboptimal response to disease-modifying therapies (DMTs) experienced low disease activity after switching to ocrelizumab, according to interim results of the LIBERTO study.

Reduced risk of psychosis relapse with continued pimavanserin use in patients with dementia
Elaine Soliven, 19 May 2022
Patients with Parkinson’s disease dementia (PDD) who continued treatment with pimavanserin had a lower risk of psychosis relapse compared with those on placebo, according to a post hoc analysis of the HARMONY* trial presented at AAN 2022.
Pelvic floor dysfunction in women warrants further attention
Audrey Abella, 17 May 2022
There appears to be a dearth of evidence on the management of nonrelaxing pelvic floor dysfunction (PFD), a debilitating condition characterized by tension of the pelvic floor muscles that frequently leads to pelvic pain, according to data presented at ACOG 2022.
Levonorgestrel IUD  staves off heavy menses in obese nulliparous women
Elvira Manzano, 17 May 2022
The use of an intrauterine device (IUD) containing levonorgestrel 52 mg cuts heavy menses in obese nulliparous women in a phase III study.
Post-TAVR SLT does not differ with edoxaban or DAPT
Roshini Claire Anthony, 16 May 2022

The risk of subclinical valve leaflet thrombosis (SLT) following transcatheter aortic valve replacement (TAVR) did not differ regardless of whether patients received edoxaban or dual antiplatelet therapy (DAPT) post-surgery, according to results of the ADAPT-TAVR* trial.

ED-dispensed mifepristone plus misoprostol improves access to early pregnancy loss care
Jairia Dela Cruz, 16 May 2022
Administering mifepristone and misoprostol in the emergency departments (EDs) appears to be effective, increasing the availability of early pregnancy loss medical management services to women during the COVID-19 pandemic in the US, as shown in a study presented at the 2022 American College of Obstetricians and Gynecologists (ACOG) Annual Clinical & Scientific Meeting.