Multidisciplinary

Top Medical News
Onasemnogene abeparvovec for spinal muscular atrophy safe in heavier babies
2 hours ago
Babies who weigh ≥8.5 kg can safely be administered with onasemnogene abeparvovec for the treatment of spinal muscular atrophy, a new study has found.
Cranberries sharpen memory, neural function in healthy seniors
Jairia Dela Cruz, 6 hours ago
Eating a small cup of cranberries daily is apparently good for the brain, enhancing memory consolidation and retrieval for everyday events as well as neural functioning in healthy older adults, as shown in a recent study.
Hypothyroidism, lower FT4 levels tied to greater T2D risk
7 hours ago
People with hypothyroidism and lower free thyroxine (FT4) levels in the reference range have a higher risk of type 2 diabetes (T2D), suggests a recent study.
Higher echocardiographic calcium score seen in CVD patients on peritoneal dialysis
Stephen Padilla, 8 hours ago
Patients undergoing peritoneal dialysis (PD) with cardiovascular disease (CVD) show significantly higher echocardiographic calcium score (ECS) than those without CVD, according to a Singapore study. This indicates a higher vascular calcification burden in the former.
Head, neck involvement tied to poor prognosis in patients with mycosis fungoides
9 hours ago
Head and neck involvement of mycosis fungoides is a predictor of a poor prognosis, according to a recent study.
CIEDs give clues to time of patient death
Tristan Manalac, 11 hours ago
Postmortem interrogation of cardiac implantable electrical devices (CIED) can help pinpoint a patient’s time of death, according to a recent study. While forensic analysis of explanted CIEDs is valid, accuracy of time determination varies across different devices.
Dextrose gel reduces need for intravenous fluids in babies with asymptomatic hypoglycaemia
12 hours ago
In neonates who have asymptomatic hypoglycaemia in the first 48 hours of life, administering dextrose gel is useful and minimizes requirement for intravenous fluids, as shown in a study.
Special Reports
Recognising inflammatory back pain and
axial spondyloarthritis: A practical referral
algorithm for primary care physicians
18 May 2022
Early identification and referral of patients with inflammatory back pain (IBP) to rheumatologists for further assessment is imperative in ensuring those with axial spondyloarthritis (axSpA) receive timely intervention. In this interview, Associate Professor Dr Fariz Yahya shared his insights into the development, use and importance of the primary care physician-targeted IBP referral algorithm, which had been published in Malaysian Family Physician 
Psoriasis is more than skin deep
01 May 2022
Psoriasis (PsO) is a lifelong, systemic inflammatory disease associated with multiple comorbidities that extends beyond just the surface of the skin.1 Recently, MIMS Doctor spoke to Dr Bong Jan Ling, a Consultant Dermatologist at Sunway Medical Centre to gather her thoughts on the current treatment landscape of PsO, specifically the risk factors of developing psoriatic arthritis (PsA), a condition closely related to PsO, and how the coronavirus disease 2019 (COVID-19) pandemic may have impacted the management of PsO. 
Aiming for Best Outcomes: Optimizing
Myelofibrosis Treatment and Management
01 May 2022
At the recent Malaysia MPN Expert Forum, Dr Harry Gill, Clinical Assistant Professor at the University of Hong Kong, presented a review of the current treatment landscape in myelofibrosis (MF), along with a detailed look at the optimization of Jakavi® (ruxolitinib), Novartis in MF management. The forum was organized in collaboration between Novartis and the Malaysian Society of Haematology (MSH).
Empagliflozin/linagliptin combination therapy:
The way forward in the joint management of
diabetes and cardiovascular disea
01 Apr 2022
Cardiovascular disease (CVD) is a common comorbidity in diabetes mellitus (DM) and its prevalence is on the rise. Studies have reported that several factors including oxidative stress, low-grade inflammation, endothelial dysfunction and autonomic neuropathy are often present in patients with DM, and may directly contribute to the increased prevalence of myocardial infarction (MI), coronary revascularisation, stroke and congestive heart failure (HF).1,2 The presence of both DM and CVD in patients increases the risk of mortality and morbidity among men and women alike.
Management of recurrent implantation failure during the COVID-19 pandemic
Dr. Ameet Patki, Dr. Prakash Mayandi, 22 Mar 2022
Recurrent implantation failure (RIF) refers to the failure to achieve a clinical pregnancy after three in vitro fertilization (IVF) attempts with at least four good-quality embryos. RIF leaves couples frustrated and desperate for answers and is challenging for clinicians to handle, compounded by the impact of the COVID-19 pandemic restrictions. Two experts, Dr Ameet Patki, Medical Director of Fertility Associates Mumbai and Hon Assoc Prof at KJ Somaiya Medical College & Hospital, India, and Dr Prakash Mayandi, Metro IVF Fertility Centre, Kuala Lumpur, Malaysia, weigh in with their views on managing RIF during the COVID-19 pandemic.
Product Highlight - Pontevia
16 Mar 2022
Galcanezumab Injection
Conference Reports
Fewer hospitalizations with omicron vs delta suggest reduced severity of omicron variant
Roshini Claire Anthony, 23 May 2022

Infection with the omicron variant of SARS-CoV-2 was less likely to result in hospitalization than infection with the delta variant, according to an observational study from Denmark presented at ECCMID 2022 and published in The Lancet.

Keto diet: Is there good evidence in MS?
Elvira Manzano, 23 May 2022
A diet rich in fat but low in carbohydrates, popularly known as the ketogenic or “keto” diet, offers clinical benefits to patients with relapsing multiple sclerosis (MS) in a phase II study. Quality of life (QoL) likewise improved, and so did disability.
Fezolinetant reduces hot flashes in menopausal women
Elaine Soliven, 21 May 2022
Treatment with fezolinetant significantly reduced the frequency and severity of vasomotor symptoms (VMS), particularly hot flashes, in women during their menopausal phase, according to the SKYLIGHT 1* trial presented at ACOG 2022.
Investigational drug gains upper hand over placebo in reducing CDI recurrence rates
Audrey Abella, 20 May 2022
SER-109, an investigational oral microbiome therapeutic, achieves superiority over placebo in reducing recurrent Clostridioides difficile infection (CDI) rates, according to updated findings from the phase III ECOSPOR-III trial.
Once-daily, low-dose elagolix reduces HMB in premenopausal women with uterine fibroids
Elaine Soliven, 20 May 2022
Once-daily (QD) administration of low-dose elagolix 150 mg led to significantly reduced heavy menstrual bleeding (HMB) in premenopausal women with uterine fibroids, according to a study presented at ACOG 2022.
Sustained benefits with ocrelizumab in relapsing-remitting MS
Roshini Claire Anthony, 19 May 2022

Patients with relapsing-remitting multiple sclerosis (RRMS) who have suboptimal response to disease-modifying therapies (DMTs) experienced low disease activity after switching to ocrelizumab, according to interim results of the LIBERTO study.

Reduced risk of psychosis relapse with continued pimavanserin use in patients with dementia
Elaine Soliven, 19 May 2022
Patients with Parkinson’s disease dementia (PDD) who continued treatment with pimavanserin had a lower risk of psychosis relapse compared with those on placebo, according to a post hoc analysis of the HARMONY* trial presented at AAN 2022.