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Once weekly injection of semaglutide causes weight loss in obese patients with heart failure with preserved ejection fraction (HFpEF), with positive shifts in symptoms and improvements in physical limitations in the STEP-HFpEF trial presented at ESC 2023.
Treatment with either nirmatrelvir or molnupiravir helps reduce mortality and hospitalization in COVID-19 patients infected with the Omicron variant and are at high-risk of progressing to severe disease, as shown in a study.
Perioperative myocardial injury (PMI), as shown by perioperative high-sensitivity cardiac troponin T (hs-cTnT) release, appears predictive of expected 30-day mortality, but not 5-year mortality, in patients undergoing cardiac surgery, reveals a recent study.
Visceral fat area (VFA) is a reliable prognostic indicator of muscle mass and is associated with nutritional, immune, and inflammatory status in patients with diverse types of cancer, such as gastric, colorectal, and nonsmall-cell lung cancers (NSCLC), claims a recent study.
People with idiopathic pulmonary fibrosis (IPF) who live near a major road tend to have a faster decrease in lung function, according to a study in Australia. Likewise, increased exposure to fine particulate matter (<2.5 μm, PM2.5) is associated with a higher rate of annual decline in diffusing capacity of the lungs for carbon monoxide (DLco).
In the phase III INSPIRE study, the novel, potent ALK tyrosine kinase inhibitor (TKI) iruplinalkib conferred a progression-free survival (PFS) benefit in patients with TKI-naïve, locally advanced, or metastatic ALK+ non-small-cell lung cancer (NSCLC).
Acetazolamide helps to reduce the chances of altitude-related adverse health effects (ARAHE) in patients with chronic obstructive pulmonary disease (COPD) in a study reported at ERS.
Special Reports
Novugen is an innovator in the generics and biosimilars market. Since its inception, it has dived in headfirst into the industry, taking on difficulties and sparking new ideas. In this exclusive interview, Novugen’s CEO Rahil Mahmood explores the strategic moves that has set the stage to launching this Malaysian jewel to the forefront of the pharmaceutical world.
Dato’ Sri Dr Azhari Rosman, Senior Consultant Cardiologist at National Heart Institute, discusses the formidable situation of hypercholesterolaemia in Malaysia while Professor Dr Peter Jan Lansberg, Lipidologist at University Medical Center Groningen, The Netherlands, puts forth the solution of prescribing the highest tolerated dose of statins like atorvastatin calcium to treat patients to target low-density lipoprotein cholesterol (LDL-C) levels.
Heart failure (HF) is a global health problem, affecting over 26 million people worldwide. In Malaysia, HF is a common cause of hospitalization, accounting for approximately 6–10% of all acute medical admissions. It is also a prevalent reason for hospital readmissions. Between the years 2007 and 2016 in Malaysia, 18% of patients were readmitted within 30 days after discharge following an index hospitalisation for HF. Notably, the in-hospital, 30-day and 1-year mortality rates were 5.3%, 11.2% and 33.1%, respectively.
Coronary artery disease (CAD) stands as the foremost cause of mortality worldwide. In 2012, CAD accounted for 98.9 deaths per 100,000 people in Malaysia. Chronic stable angina is a common manifestation of CAD. The presence of chronic angina significantly increases the risk of major cardiovascular (CV) events, reduces quality of life (QoL) and adversely affects activities of daily living. Patients with this condition often present with several comorbidities, including hypertension, diabetes mellitus (DM),dyslipidaemia, atrial fibrillation (AF) and heart failure, further complicating the treatment approach.
People with
glaucoma (PwG) are at high risk for developing Dry Eye disease (DED), 40-59% of
PwG are diagnosed with DED worldwide.
At the recent MPN Expert Forum held in Kuching, Dr Chew Lee Ping (Consultant Haematologist, Sarawak General Hospital) and Dr Yong Kar Ying (Clinical Haematologist Hospital Miri Sarawak) shared their expert opinion on treating hydroxyurea (HU) resistance/intolerance in Polycythaemia Vera (PV) patients, where real-life patients were managed successfully.
Consultant Cardiologist Dr Yew Kuan Leong elaborates on the efficacy and safety of inclisiran, a new LDL cholesterol-lowering injectable medication now available in Malaysia, and the target group of patients benefiting from the additional LDL cholesterol-lowering therapy.
Conference Reports
Acetazolamide helps to reduce the chances of altitude-related adverse health effects (ARAHE) in patients with chronic obstructive pulmonary disease (COPD) in a study reported at ERS.
Tacrolimus given once daily significantly reduced the 3-year incidence of chronic lung allograft dysfunction (CLAD) in lung transplant patients compared with standard immunosuppressant in the open label, multicentre, ScanCLAD trial presented at ERS 2023.
In the merged analysis of the IMpower133 trial and IMbrella A open-label extension study, the combination of the PD-L1 inhibitor atezolizumab and a chemotherapy regimen comprising carboplatin and etoposide (CP/ET) demonstrated potential for survival benefit of up to 5 years in patients with extensive stage-small-cell lung cancer (ES-SCLC).
Treatment with dupilumab significantly improves lung function in children with moderate-to-severe type 2 asthma compared with placebo, according to two post hoc analyses presented at ERS 2023.
Two studies presented at ERS 2023 demonstrated the potential of a continuous positive airway pressure (CPAP) machine to address cardiovascular (CV) risks in individuals with obstructive sleep apnoea (OSA).
Use of e-cigarette (EC) shows a significant relation with a higher incidence of chronic stress and is indicative of poorer quality of life (QoL) in young adults, suggests a study presented at ERS 2023.
Fatigue in people with chronic obstructive pulmonary disease (COPD) may be caused by factors such as shortness of breath, sleep quality, pain, and fatigue-related catastrophizing, according to the FAntasTIGUE study.
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