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Top Medical News
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
A risk prediction model based on high-resolution computed tomography (HRCT) variables appear useful for patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD), suggests a study.
Despite the lack of significant contrast use, nearly one in six patients undergoing transcatheter mitral valve repair (MitraClip) develop acute kidney injury (AKI), which is associated with device failure or other severe conditions, according to a study.
Ambulatory blood pressure monitoring (ABPM) provides significant data on heart rate (HR) parameters, which can help predict the risk of mortality in patients with hypertension, a study has found.
Adherence to the Mediterranean diet (MD) may reduce the risk of rheumatoid arthritis (RA) in women who are ever-smokers, according to the French E3N-EPIC* study.
A pulmonary rehabilitation programme for chronic obstructive pulmonary disease (COPD) yields sustained improvements in anxiety and quality of life of patients over 2 years, a study has shown. However, the positive changes in dyspnoea, depression, and stress symptoms may only last short term.
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Special Reports
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
At the recent Pfizer webinar “Pneumococcal Vaccination in High-Risk Individuals: Are We Doing It Right?”, Dr Petrick Periyasamy, head of the Hospital Canselor Tuanku Muhriz UKM Infectious Diseases Unit, discussed the currently known epidemiology of adult pneumococcal disease (PD),as well as the impact of vaccines on PD prevention in at-risk populations.
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Alpelisib 50 mg, 150 mg and 200 mg FC tab
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
At a Pfizer-sponsored webinar held in collaboration with the Malaysian Medical Association, several distinguished speakers shared their insights into the current SARSCOV-2 pandemic, better known as COVID-19. Topics discussed include current and future therapeutic interventions from both local and global perspectives.
Heart failure (HF) is a global public health concern, affecting about 38 million individuals globally.1 Despite significant medical advances, HF remains a chronic and progressive condition that can negatively affect patients’ quality of life (QoL).2,3 In this case study, Dr Abdul Muizz shares his clinical experience in managing a patient with HF and reduced ejection fraction (HFrEF), following the percutaneous coronary intervention, showing how the initiation of sacubitril/valsartan therapy (an angiotensin receptor/neprilysin inhibitor [ARNI]) changed the clinical outcome of this patient.
Conference Reports
HIV patients hospitalized for COVID-19 are at a higher risk of mortality than those hospitalized without HIV in a new study reported at HIV Glasgow 2020.
Using regional citrate for anticoagulation during dialysis significantly extends the lifespan of dialysis filter compared with systemic heparin anticoagulation, although this has no impact on the patients’ mortality rate over 1 year, according to the RICH study presented at ASN 2020.
The efficacy of lanifibranor in reducing histological markers of non-alcoholic steatohepatitis (NASH) is comparable in patients with and without type 2 diabetes (T2D), according to the phase IIb NATIVE study presented as a poster at AASLD 2020.
Use of the potent and selective PPARδ* agonist seladelpar led to improvements in histologic responses and liver chemistry in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH), a phase II study has shown.
Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.
Reductions in liver fat and adipose tissue volumes were sustained in patients with type 2 diabetes (T2D) with the addition of the SGLT-2* inhibitor dapagliflozin (DAPA) and the DPP-4** inhibitor saxagliptin (SAXA) to metformin (MET), compared with a regimen comprising glimepiride (GLIM)+MET, according to the extension period results of a phase IIIb trial.
Patients with ST-elevation and COVID-19 have different characteristics than those without COVID-19, and may have a higher risk of in-hospital mortality and stroke, according to initial results of the NACMI* registry study presented at TCT Connect 2020.
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