Multidisciplinary

Urological outcomes favourable after genital gender affirming surgery in transgender men

an hour ago

The complication rate is high in transgender men undergoing genital gender affirming surgery with urethral lengthening, which is considered a complex procedure, but no clinically relevant differences in urological functioning have been recorded following treatment of these complications, reports a study.

For patients with rheumatoid arthritis, diets matter

Jairia Dela Cruz, 4 hours ago

Foods factor in the management of symptoms of rheumatoid arthritis (RA), and several dietary approaches help by removing staples that promote inflammation or by adding more of anti-inflammatory edibles and altering the gut microbiota, according to a team of researchers.

Plant-based diet before pregnancy may cut GDM risk

Pearl Toh, 17 hours ago

Women who follow a healthy plant-based diet before pregnancy have a lower risk of developing gestational diabetes mellitus (GDM), suggests a large, prospective cohort study presented at ADA 2020 Annual Meeting.

Out-of-hours vs in-hours PPCI have comparable outcomes

18 hours ago

Patients receiving out-of-hours primary percutaneous coronary intervention (PPCI) endure a slightly longer door-to-balloon time (DTBT) but otherwise have comparable outcomes to those receiving the procedure during regular working hours, a recent study has found.

Empagliflozin near to us: Insights from its use in Asians

09 Jul 2020

In this fourth issue, join us as we discover the unique biology Asians have with respect to diabetes. Take a closer look at trials evaluating whether empagliflozin’s cardiovascular and renal benefits – as analysed in Asians – are consistent with the overall trial population, and how it addresses unmet needs.

Achieving full functional recovery in MDD: How do we get there?

29 Jun 2020

The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illness. On the first day, eminent local and internationalexperts weighed in on the treatment of major depressive disorder (MDD), including in the elderly and incases of coexisting anxiety.

Early Treatment Intensification in T2DM, The Time is Now

29 Jun 2020

At the Novartis-sponsored VERIFY Soft Launch held at Le Meridien, Kuala Lumpur, two distinguished speakers spoke on the latest updates in glucose-lowering therapy and the benefit of early treatment intensification using combination therapy (ie, vildagliptin/metformin) in the management of T2DM.

HK in CKD: Do diet, HD frequency matter?

Elvira Manzano, 28 Jun 2020

Hyperkalaemia (HK) occurrence and recurrence are frequent in advanced CKD*, creating a perfect storm for cardiovascular events and death, says Professor Juan-Jesus Carrero from the Karolinska Institute, Solna, Sweden, at ERA-EDTA 2020. Given these risks, acutely elevated potassium (K+) should merit clinical attention.

No increased ophthalmic risk with roxadustat treatment in DD CKD-related anaemia

Roshini Claire Anthony, 28 Jun 2020

Roxadustat treatment for anaemia in patients with dialysis-dependent chronic kidney disease (DD CKD) does not come with an increased risk of ophthalmic abnormalities, according to a phase III trial conducted in Japan.

Plant-based diet before pregnancy may cut GDM risk

Pearl Toh, 13 Jul 2020

Enzalutamide-ADT extends OS in nmCRPC

Roshini Claire Anthony, 13 Jul 2020

The addition of enzalutamide to androgen deprivation therapy (ADT) improved overall survival (OS) in men with nonmetastatic castration-resistant prostate cancer (nmCRPC), demonstrated the phase III PROSPER* trial.

Global registry links treatments to death in thoracic cancer patients with COVID-19

Christina Lau, 13 Jul 2020

Prior treatment with chemotherapy alone, chemotherapy plus immunotherapy, steroids or anticoagulants is associated with an increased risk of death in patients with thoracic cancer who develop coronavirus disease 2019 (COVID-19), new data from the global TERAVOLT (Thoracic Cancers International COVID-10 Collaboration) registry have shown.

Ipatasertib-paclitaxel displays potential as first-line treatment for inoperable advanced TNBC

Roshini Claire Anthony, 10 Jul 2020

Treatment with ipatasertib plus paclitaxel in the first-line setting demonstrated a trend toward improved overall survival (OS) compared with paclitaxel alone in women with inoperable locally advanced/metastatic triple-negative breast cancer (TNBC), according to final results of the phase II LOTUS trial.

Vitamin D protective against advanced cancer?

Pearl Toh, 09 Jul 2020

Vitamin D supplementation can reduce the incidence of advanced cancer among older adults, in particular those with a normal BMI but not those who are overweight or obese, suggests the large VITAL* randomized study presented during the ASCO 2020 Meeting.

Netakimab improves treatment outcomes in PsA

Audrey Abella, 09 Jul 2020

The anti-interleukin 17A antibody netakimab reduces disease activity and skin manifestations in patients with active psoriatic arthritis (PsA), consequently improving patient-reported outcomes (PROs), analyses of the phase III PATERA trial have shown.

Novel JAK1 inhibitor on par with adalimumab in RA over 52 weeks

Pearl Toh, 08 Jul 2020

The investigational JAK1* inhibitor filgotinib was noninferior to adalimumab in reducing disease activity in patients with moderate-to-severe rheumatoid arthritis (RA) who had inadequate response to methotrexate (MTX-IR), according to the FINCH 1 study presented at EULAR 2020 Virtual Meeting.

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