Multidisciplinary

Top Medical News
High-flow nasal cannula oxygen therapy better than CPAP in preterm infants
Tristan Manalac, 16 minutes ago
Compared with continuous positive airway pressure (CPAP), respiratory support using high-flow nasal cannula oxygen therapy (HNFC) appears to yield better clinical outcomes in preterm infants, according to a recent meta-analysis.
Vilobelimab augments treatment armamentarium for critically ill COVID-19 patients
Audrey Abella, 16 minutes ago
In the phase III part of the PANAMO trial, the anti-C5a monoclonal antibody vilobelimab, when added to standard of care (SoC), improved survival in COVID-19 patients who required invasive mechanical ventilation (IMV).
C-reactive protein levels unrelated to spinal pain in kids
an hour ago
There appears to be no link between C-reactive protein (CRP) levels and the trajectory of spinal pain in children and adolescents, a recent study has found.
Nonoptimal serum calcium levels worsen mortality in heart attacks
2 hours ago
Serum calcium levels that are either too high or too low appear to aggravate the risk of in-hospital mortality in patients with acute myocardial infarction (AMI), reports a recent study.
CGM improves HbA1c levels in T1D
Roshini Claire Anthony, 19 hours ago

Continuous glucose monitoring (CGM) with alarms for high or low blood sugar levels better controlled HbA1c levels than personal fingerstick monitoring in patients with type 1 diabetes (T1D), results of the FLASH-UK trial showed.

Temperature tied to body weight in individuals with HF
Audrey Abella, 20 hours ago
In a nationwide observational study, an association between temperature and body weight has been observed in individuals with heart failure (HF).
LSM improves prediction of cholangitis outcomes
21 hours ago
Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) is independently associated with primary biliary cholangitis (PBC) outcomes, a study has shown.
Special Reports
When dengue fever becomes severe
01 Nov 2022
Dengue has been around for more than a century from the first reported outbreak in 1902,1 with experts advising healthcare professionals (HCPs) from time to time to alert HCPs to the threats of dengue. This is because the dengue virus has been evolving and can cause severe illness especially among vulnerable patients regardless of age. In this fourth interview of a series focused on dengue, Dr Shanthi Ratnam, Consultant Physician and Intensivist, elaborated on the risks, impact and management of dengue, and advocated dengue as a public health priority.
Pregabalin mainstay of treatment in painful diabetic neuropathy
01 Nov 2022
At the recent Novugen Expert Forum, held in Penang, Dr Khaw Chong Hui discussed the prevalence of painful diabetic neuropathy (PDN), role of pregabalin in the treatment of PDN, its place in treatment recommendations of major international pain guidelines and its proven safety and efficacy.
Molecular Pathogenesis and Current Treatment Landscape In MPN, With A Focus On PV
01 Nov 2022
The recent Northern Haematology Update, held in Penang, saw Dr Christopher Ng, Dr Tan Sui Keat and Dr Carol Goh present on various aspects of myeloproliferative neoplasms (MPN)and its management. Dr Christopher Ng, a haematology trainee at Hospital Sultanah Bahiyah, Kedah, discussed the role of mutations as drivers of disease, with a focus on polycythaemiavera (PV) and essential thrombocythaemia (ET).
Role of Primary Care in the Diagnosis and Management of Multiple Myeloma
01 Nov 2022
Early detection is vital to the successful treatment of multiple myeloma (MM), a type of bone marrow cancer characterised by abnormal expansion of malignant clonal plasma cells in the bone marrow.
Iliadin® nasal drops safe, effective for infants and young children
01 Nov 2022
liadin® (oxymetazoline hydrochloride 0.01%) has been specially formulated in low dose to treat acute rhinitis, vasomotor rhinitis, allergic rhinitis, paranasal sinusitis, and nasal congestion in infants and young children. Iliadin®, the original brand for oxymetazoline has been in the market for over 60 years. Iliadin® is a direct-acting sympathomimetic with marked alpha-adrenergic activity that causes vasoconstriction—reduces swelling and congestion—when applied to mucous membranes.
Timely treatment of patients at risk for severe COVID-19 prevents severe outcomes
Dr. Asok Kurup, Dr. Alex Soriano, 31 Oct 2022

Despite widespread uptake of vaccinations, COVID-19 remains a serious health issue for high-risk patients, owing to the emergence of new variants of concern (VOCs), waning immunity, and breakthrough infections.

At a recent symposium in Singapore, esteemed experts Dr Asok Kurup, Consultant Infectious Diseases Physician at Mount Elizabeth Medical Centre, Singapore, and Dr Alex Soriano, Head of Infectious Diseases Department, Hospital Clínic of Barcelona and Assistant Professor, University of Barcelona, Spain, gave insights on the evolution of global trends since the start of the COVID-19 pandemic and discussed key challenges in managing high-risk patients with COVID-19 in the ICU. They also highlighted early treatment strategies to minimize the burden of COVID-19 on healthcare systems.

Dapagliflozin DELIVERs across full HF spectrum regardless of LVEF
Elvira Manzano, 04 Oct 2022
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
Conference Reports
CT angiography may increase potential recipients of EVT for acute ischaemic stroke
Roshini Claire Anthony, 27 Nov 2022

Using collateral flow findings, as seen on computed tomographic (CT) angiography, may widen the population who can undergo late endovascular treatment (EVT) for acute ischaemic stroke (AIS), according to findings of the MR CLEAN-LATE trial.

No CV benefits with cooler dialysate
Elvira Manzano, 27 Nov 2022
The use of a cooler dialysate during maintenance haemodialysis does not offer cardiovascular (CV) benefits to patients in the MyTEMP trial.
Lower all-cause death, fewer HF events with empagliflozin in acute HF
Roshini Claire Anthony, 25 Nov 2022

Patients hospitalized with acute heart failure (HF) have a reduced risk of subsequent HF events or all-cause mortality if treated with once-daily empagliflozin while in hospital, according to results of the EMPULSE trial presented at HFSA 2022.

Letermovir as good as valganciclovir for CMV prophylaxis
Elaine Soliven, 25 Nov 2022
The novel antiviral letermovir is as good as the current standard of care valganciclovir in preventing cytomegalovirus (CMV) infection in post-kidney transplant patients, but with less toxicity, according to a phase III trial presented at IDWeek 2022.
Post-surgery emergence delirium in kids has no long-term impact
Roshini Claire Anthony, 23 Nov 2022

The use of general anaesthesia (GA) in children undergoing elective surgeries does not lead to long-term deterioration in behavioural outcomes, according to a study presented at Anesthesiology 2022.

TB rates elevated after ART initiation in PLHIV
Roshini Claire Anthony, 21 Nov 2022

People living with HIV (PLHIV) who initiate antiretroviral therapy (ART) are at an increased risk of developing tuberculosis (TB), particularly in the first 3 months after starting ART, according to a study presented at HIV Glasgow 2022.

Low use of CVD prevention strategies in people with HIV
Roshini Claire Anthony, 18 Nov 2022

There is an underutilization of cardiovascular disease (CVD) prevention strategies in people living with HIV (PLHIV) who are at risk of CVD, according to a study presented at HIV Glasgow 2022.