Molluscum contagiosum is an infection due to poxvirus that results into discrete skin lesions with central umbilication.
Spread is by skin-to-skin contact, fomites spread and autoinoculation.
Patients with atopic dermatitis, HIV or immunodeficiency are particularly susceptible.
Incubation period may be from 2-7 weeks.
In children, it usually presents with lesions on the face, scalp, ears, trunk and extremities and crural folds while in adults, it is typically sexually transmitted and affects the groin, genital area, thighs and lower abdomen.
Romiti R, Ribeir AP, Grinblat BM, et al. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatr Dermatol. 1999;16:228-231. PMID: 10383783
Skinner RB. Treatment of molluscum contagiosum with imiquimod 5% cream. J Am Acad Dermatol. 2002;47(Suppl 4):S221-S224. PMID: 12271282
Silverberg NB, Sidbury R, Mancini AJ. Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients. J Am Acad Dermatol. 2000;43:503-507. PMID: 10954663
Skinner RB Jr. Imiquimod. Dermatol Clin. 2003;21:291-300. PMID: 12757252
Syed TA, Goswami J, Ahmadpour OA, et al. Treatment of molluscum contagiosum in males with an analog of imiquimod 1% cream: a placebo-controlled, double-blind study. J Dermatol. 1998;25:309-313. PMID: 9640884
Syed TA, Lundin S, Ahmad M. Topical 0.3% and 0.5% podophyllotoxin cream for self-treatment of molluscum contagiosum in males. A placebo controlled, double-blind study. Dermatology. 1994;189:65-68. PMID: 8003791
Stulberg DL, Hutchinson AG. Molluscum contagiosum and warts. Am Fam Physician. 2003;67:1223-1240. PMID: 12674451
Toro JR, Sanchez S, Turiansky G, et al. Topical cidofovir for the treatment of dermatologic conditions: verruca, condyloma, intraepithelial neoplasia, herpes simplex and its potential use in smallpox. Dermatol Clin. 2003;21:301-309. PMID: 12757253
Tyring SK. Molluscum contagiosum: the importance of early diagnosis and treatment. Am J Obstet Gynecol. 2003;189(3 suppl):S12-S16. PMID: 14532898
Zabawski EJ. A review of topical and intralesional cidofovir. Dermatol Online J. 2000;6:3. Accessed 22 Jul 2003. PMID: 11328613
Cheng SY. Molluscum contagiosum. In: Lo KK, Chong LY, Tang YM. Handbook of dermatology & venereology: social hygiene handbook. 2nd ed. Western District, Hong Kong: Hygiene Service, Dept of Health; 1997
Other poxviruses that infect humans: parapoxviruses, molluscum contagiosum, and tanapox. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett's principles and practice of infectious diseases. 6th ed. Philadelphia: Elsevier Churchill Livingstone, Inc; 2005
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