meningitis%20-%20acute,%20bacterial
MENINGITIS - ACUTE, BACTERIAL

Acute meningitis is the infection of the subarachnoid space and cerebrospinal fluid by bacteria that may cause local and systemic inflammatory response.
There is the classic triad of symptoms of fever, neck stiffness and altered level of consciousness.
Other symptoms include chills, myalgia, photophobia, severe headache, focal neurologic symptoms, nausea, vomiting, seizures and some patients may present with rash.

 

Definition

  • Meningitis is the infection of the meninges and subarachnoid space that is usually caused by bacteria results in high mortality and morbidity throughout the world

Etiology

  • H influenza type B, N meningitidis and S pneumoniae 
  • Causative agents depend on the age of the patient and predisposing factors
  • The introduction of conjugated vaccines have caused decline in the incidence of bacterial meningitis in children thus majority of cases are now present in the adult population

Other causes of acute meningitis include the following:

  • Spirochetes eg Treponema pallidum
  • Mycobacteria eg Mycobacterium tuberculosis
  • Fungi eg Cryptococcus, Coccidioides, Sporothrix
  • Viruses eg herpes simplex virus (HSV), varicella zoster, cytomegalovirus (CMV), enterovirus
  • Protozoa and helminths

Signs and Symptoms

  • Classic triad: Fever, neck stiffness and an altered level of consciousness
  • Other symptoms:
    • Chills
    • Myalgia
    • Photophobia
    • Severe headache
    • Focal neurologic symptoms (eg cranial nerve palsies, ataxia, dilated/unequal and poorly reacting pupils - late sign)
    • Nausea/vomiting
    • Seizures (late sign)
    • Some patients may present with petechial rash
    • Some patients may not present with the classic signs (eg alcoholics, patients who are immunocompromised and who had meningitis after neurosurgery)
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Dr. Joseph Delano Fule Robles, 05 Dec 2017

Results of a study conducted by the Chinese University of Hong Kong (CUHK) revealed that patients who recovered from hepatitis B virus (HBV) infection are still at risk for hepatocellular carcinoma (HCC). 

30 Mar 2018
A US study suggests that expanding HIV screening to reduce undiagnosed infections and increasing access to care and treatment to achieve viral suppression are important to lessen HIV transmission. It is also imperative that prevention methods, such as condoms and pre-exposure prophylaxis, be easily accessed, particularly among young men who have sex with men (MSM) and MSM of colour.
Saras Ramiya, 10 Aug 2018
The National Institutes of Health (NIH) and International Medical University (IMU) strengthens their research collaboration with the recent signing of a Memorandum of Understanding (MoU).