Melanoma is a skin neoplasm that originates from malignant transformation of melanocytes.
It commonly occurs in the extremities of women and on trunk or head and neck in men.
Metastases are via lymphatic and hematogenous routes.
Patients with advanced, unresectable melanoma may derive overall survival (OS) and progression-free survival (PFS) benefits when treated with a nivolumab plus ipilimumab combination or nivolumab alone, according to 4-year results of the phase III CheckMate 067* trial presented at ESMO 2018.
The FDA approval and subsequent use of checkpoint blockade immunotherapy (CBI) and BRAFV600 targeted therapy almost doubled the overall survival (OS) in patients with stage 4 melanoma with brain metastases (MBM), according to a recent US-based study.
Pembrolizumab delivered intravenously every 3 weeks for 1 year extended recurrence-free survival (RFS) in patients with resected stage III melanoma, according to results of the KEYNOTE-054/EORTC 1325-MG* trial.
Dermoscopy plus conventional and modified clinical ABCD criteria (amelanotic, bleeding bump, colour uniformity, de novo at any diameter) improves diagnosis of paediatric melanoma (PM), suggests a recent study. Dermoscopy helps in differentiating spitzoid from nonspitzoid melanomas.
Individuals with advanced melanoma treated with pembrolizumab had better overall survival (OS) compared with those treated with ipilimumab regardless of pembrolizumab dosing schedule, results of the final survival analysis of the KEYNOTE-006* trial showed.
A 10 mg/kg dose of ipilimumab led to significant improvement in overall survival (OS) in individuals with advanced melanoma compared with a 3 mg/kg dose, but was also associated with a higher number of treatment-related adverse events (TRAEs), according to findings of a recent study.
Stigmatization is likely among patients with psoriatic lesions on the back of their hands. They require effective treatment, particularly female patients as they are more sensitive to stigmatization, suggests a recent study.
Chronic pruritus is a diverse and aetiologically complex skin condition and thus requires a similarly comprehensive treatment approach, according to Dr Siti Aisah who gave a lecture at the recently concluded 23rd Regional Conference of Dermatology (RCD 2018) in Surabaya, Indonesia.
Acidity of the skin appears to be significantly higher in atopic dermatitis (AD) patients than in controls without the condition, indicating that increased skin pH may heighten the risk of developing AD, according to a study.
An association exists between stress and quality of life (QoL) in patients with psoriasis vulgaris, according to a poster presented at the 23rd Asian-Australasian Regional Conference of Dermatology (RCD 2018) held in Surabaya, Indonesia.