lung%20cancer
LUNG CANCER
Lung cancer is having a malignant tumor in the lungs especially in the cells lining air passages.
Primary tumor-related signs and symptoms are cough, dyspnea, hemoptysis, and chest discomfort.
Signs and symptoms due to intrathoracic spread may involve the nerves (hoarseness, dyspnea, muscle wasting of upper limb, Horner's syndrome), chest wall and pleura (chest pain, dyspnea) and vascular structures (facial swelling, dilated neck veins, cardiac tamponade) & viscera (dsyphagia).
The signs and symptoms due to metastatic spread are bone pain with or without pleuritic pain, neurologic symptoms, limb weakness, unsteady gait, cervical lymphadenopathy, and skin nodules.

Surgical Intervention

Surgery for Non-Small Cell Lung Cancer (NSCLC)
  • Resectability of tumor should be fully assessed
  • May offer the best chance of survival & possible cure in non-small cell lung cancer (NSCLC) patients with Stage I-II disease
    • May be considered in patients with N2 disease responsive to induction chemotherapy
  • Surgery is recommended for patients with the following:
    • ≥8 mm solid nodule on LDCT screening that has high probability of cancer as shown on PET/CT scan
    • ≥8 mm solid nodule that increased in size in chest CT &/or PET/CT scan with high probability for cancer
    • ≥15 mm solid nodule with the same measurements in LDCT after 6 months or in PET/CT scan with high probability for cancer
    • ≥6 mm part solid nodule with ≥8 mm solid component in follow-up LDCT with high probability for cancer in PET/CT scan
    • New or growing part solid nodule with ≥4 mm solid component in LDCT with high probability for cancer in chest CT scan with or without contrast &/or PET/CT scan
    • New or growing NS nodule ≥20 mm in size during follow-up or annual LDCT
  • Treatment of choice for stage I & II non-small cell lung cancer (NSCLC)
    • In the absence of medical contraindications to surgery, complete resection (ie lobectomy) with clear surgical margins should be achieved as much as possible
    • In patients with comorbidities who are not able to tolerate lobectomy (eg patients with impaired pulmonary function), sublobar resection (segmentectomy or wedge resection) is recommended
    • Nodal dissection is preferred over simple intraoperative sampling for mediastinal lymph node
    • Sleeve lobectomy is recommended for total resection of centrally or locally advanced non-small cell lung cancer (NSCLC)
    • Segmental or wedge resection is recommended for patients with impaired pulmonary function
  • Surgery in stage IIIA N2 lung cancer is controversial
    • Surgery is considered in resectable stage IIIA N0-1 tumors, followed by adjuvant chemotherapy
    • Usually not recommended if with involvement of N2; patient may undergo chemotherapy prior to surgery to decrease the tumor size, eliminate micrometastases & to improve patient’s tolerance to procedure
  • Video-assisted thoracic surgery (VATS) is a less invasive & reasonable approach for patients with no anatomic or surgical contraindication
  • For highly selected patients with recurrent NSCLC, stereotactic radiation surgery & surgical resection of isolated cerebral metastasis are recommended
 
Surgery for Small Cell Lung Cancer (SCLC)
  •  Considered only for patients with clinical stage I-IIA & in limited disease (LD) patients with sufficient pulmonary function & no evidence of metastases to mediastinal or supraclavicular lymph nodes
    • Patients with clinical stage in excess of T1-2, N0 do not benefit from surgery
  • Lobectomy or pneumonectomy should be done followed by detailed dissection of the mediastinal lymph nodes
  • Platinum-based adjuvant chemotherapy is recommended after complete resection
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