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JUVENILE IDIOPATHIC ARTHRITIS
Treatment Guideline Chart
Juvenile idiopathic arthritis was formerly known as juvenile rheumatoid arthritis or juvenile chronic arthritis.
It presents as chronic joint swelling, pain with functional limitation for at least 6 weeks of unknown cause that starts before 16 year of age.
It is the most common autoimmune-autoinflammatory disease in children.
Around half of the children with juvenile idiopathic arthritis may have active disease until adulthood.

Juvenile Idiopathic Arthritis References

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  2. Beukelman T, Patkar NM, Saag KG, et al. 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: Initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res (Hoboken). 2011 Apr;63(4):465-482. doi: 10.1002/acr.20460. PMID: 21452260
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  4. Furst DE, Keystone EC, Fleischmann R, et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2009. Ann Rheum Dis. 2010 Jan;69(Suppl I):i2-i29. doi: 10.1136/ard.2009.123885. PMID: 19995740
  5. Hahn Y, Kim J. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis. Korean J Pediatr. 2010 Nov;53(11):921-930. doi: 10.3345/kjp.2010.53.11.921. PMID: 21218013
  6. Hayward K, Wallace CA. Recent developments in anti-rheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis. Arthritis Research & Therapy. 2009;11(1):216. doi: 10.1186/ar2619. PMID: 19291269
  7. Kim KH, Kim DS. Juvenile idiopathic arthritis: diagnosis and differential diagnosis. Korean J Pediatr. 2010 Nov;53(11):931-935. doi: 10.3345/kjp.201053.11.931. PMID: 21218014
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  9. Philpott J, Houghton K, Luke A; Canadian Paediatric Society, Healthy Active Living and Sports Medicine Committee, Canadian Academy of Sport Medicine, Paediatric Sport and Exercise Medicine Committee. Physical activity recommendations for children with specific chronic health conditions: juvenile idiopathic arthritis, hemophilia, asthma and cystic fibrosis. Paediatr Child Health. 2010 May;20(3):167-172. PMID: 20445355
  10. Weiss JE, Ilowite NT. Juvenile idiopathic arthritis. Pediatr Clin North Am. 2005 Apr;52(2):413-442. http://www.ncbi.nlm.nih.gov/pubmed/?term=15820374. PMID: 15820374
  11. Sztajnbok F, Cornel-Martinez DL, Diaz-Maldonado A, et al. Discordance between physician’s and parent’s global assessments in juvenile idiopathic arthritis. Jun 16, 2006. Rheumatology. 2007 Jan;46(1):141-145. http://rheumatology.oxfordjournals.org/content/46/1/141.full.pdf. Accessed 11 Aug 2011. PMID: 16782733
  12. Cassidy JT. Juvenile rheumatoid arthritis. In: Firestein GS, Budd RC, Harris ED Jr, et al. Kelley's Textbook of Rheumatology. 7th. Philadelphia: Elsevier W.B. Saunders; 2005.
  13. DeWitt EM, Schanberg LE, Rabiovich CE. Treatment of Rheumatic Diseases. In: Kliegman RM, Stanton BF, St Geme JW III, et al, eds. Nelson textbook of Pediatrics. 19th. Philadelphia: Saunders, Elsevier; 2011.
  14. Wu EY, Van Mater HA, Rabinovich CE. Juvenile idiopathic arthritis. In: Kliegman RM, Stanton BF, St Geme JW III, et al, eds. Nelson textbook of Pediatrics. 19th. Philadelphia: Saunders, Elsevier; 2011.
  15. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  16. The Royal Australian College of General Practitioners (RACGP) Juvenile Idiopathic Arthritis Working Group. Clinical guideline for the diagnosis and management of juvenile idiopathic arthritis. http://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/cp119-juvenile-arthritis.pdf. Aug 2009
  17. U.S. Food and Drug Administration. FDA drug safety communication: new boxed warning for severe liver injury w/ arthritis drug Arava (leflunomide). FDA. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformati. Jul 2010. Accessed 12 Aug 2011
  18. The Royal Australian College of General Practitioners (RACGP) Juvenile Idiopathic Arthritis Working Group. Recommendations for the diagnosis and management of juvenile idiopathic arthritis. http://www.racgp.org.au/your-practice/guidelines/musculoskeletal/juvenileidiopathicarthritis/. Aug 2009
  19. Costa V, Ungar W, Hancock R, et al. The use of biological modifiers in polyarticular-course juvenile idiopathic arthritis. http://pede.ccb.sickkids.ca/pede/task.jsp.DeWitt. Jan 2010.
  20. National Institute for Health and Care Excellence. NICE guidance on biologic drugs for the treatment of juvenile idiopathic arthritis. NICE. http://www.nice.org.uk/. Feb 2012.
  21. National Institute for Health and Care Excellence. Tocilizumab for the treatment of systemic juvenile idiopathic. NICE. http://www.nice.org.uk/nicemedia/live/12817/53297/53297.pdf. Dec 2011.
  22. Ringold S, Weiss PF, Beukelman T, DeWitt EM, et al; American College of Rheumatology. 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Rheum. 2013 Oct;65(10):2499-2512. http://dx.doi.org/10.1002/art.38092. PMID: 24092554
  23. Cavallo S, Feldman D. Rehabilitation and psychosocial issues in juvenile idiopathic arthritis. In: Hochberg MC, Gravallese EM, Silman AJ, et al. Rheumatology. 7th ed. Philadelphia, Pennsylvania, USA: Saunders, Elsevier; 2019. 924-932. :924-932.
  24. Cellucci T, Guzman J, Petty RE, et al. Management of juvenile idiopathic arthritis 2015: a position statement from the Pediatric Committee of the Canadian Rheumatology Association. J Rheumatol. 2016 Oct;43(10):1773-1776. doi: 10.3899/jrheum.160074. PMID: 27698103
  25. Crayne CB, Beukelman T, Courtney B. Juvenile idiopathic arthritis. Pediatr Clin of N Am. 2018 Aug;65(4):657-674. doi: 10.1016/j.pcl.2018.03.005.
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  28. Giancane G, Alongi A, Rosina S, et al. Recent therapeutic advances in juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol. 2017 Aug;31(4):476-487. doi: 10.1016/j.berh.2018.01.001. PMID: 29773268
  29. Grom AA. Juvenile idiopathic arthritis: epidemiology and immunopathogenesis. UpToDate. http://www.uptodate.com. Mar 2018.
  30. Hahn YS, Kim JG. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis. Korean J Pediatr. 2010 Nov;53(11):921-930. doi: 10.3345/kjp.2010.53.11.921. PMID: 21218013
  31. Hashkes PJ, Laxer RM. Management of juvenile idiopathic arthritis. In: Hochberg MC, Gravallese EM, Silman AJ, et al. Rheumatology. 7th ed. Philadelphia, Pennsylvania, USA: Saunders, Elsevier; 2019. 898-909. :898-909.
  32. Klein-Gitelman M. Classification of juvenile arthritis. UpToDate. http://www.uptodate.com. Sep 2017.
  33. National Institute for Health and Care Excellence (NICE). Abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis. NICE. http://www.nice.org. Dec 2015.
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  36. Kimura Y. Systemic juvenile idiopathic arthritis: Treatment. UpToDate. http://www.uptodate.com. 2 Apr 2019. Accessed 9 Aug 2019.
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  41. Sudoł-Szopińska I, Znajdek M, Gietka P, et al. Imaging of juvenile spondyloarthritis part II: Ultrasonography and magnetic resonance imaging. J Ultrason. 2017 Sep;17(70):176-181. doi: 10.15557/JoU.2017.0026. Accessed 16 Aug 2019. PMID: 29075522
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