Ischemic stroke occurs when a blood vessel supplying the brain is obstructed.
Consider stroke in any patient presenting with sudden focal neurological deficit or any alteration in level of consciousness.
Rapid evaluation is essential for sure of time-sensitive treatments.
Determine if patient's symptoms are due to stroke and exclude stroke mimics (eg migraine, hypertensive encephalopathy, hypoglycemia, seizures or post-ictal paresis); identify other conditions requiring immediate intervention and determine the potential causes of stroke.
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
The eicosapeptide nerinetide did not improve outcomes in patients with large vessel occlusion-related acute ischaemic stroke who underwent endovascular thrombectomy (EVT). However, patients not treated with alteplase appeared to derive some benefit, results from the multinational ESCAPE-NA1* trial showed.
A novel, noninvasive wearable brain stimulation device that delivers continuous transcranial magnetic stimulation to induce the brain to rewire itself significantly increases brain activity and is safe in patients with chronic ischaemic stroke — thus presenting a step forward to improving motor function after stroke, suggests a preliminary study presented at ISC 2020 Meeting.
Being male and having a high genetic predisposition to sustain an acute vascular event (AVE) predict greater risks of stroke and myocardial infarction (MI) than either factor does alone in a population of middle-aged individuals without vascular risk factors, as shown in a study presented at the International Stroke Conference (ISC) 2020.
Statins do not contribute to an increased risk of intracerebral haemorrhage in individuals with previous stroke, with the risk even lower in the subgroup of those who have had ischaemic stroke, a recent study has shown.
Patients with atherosclerotic disease who have had an ischaemic stroke or transient ischaemic attack (TIA) may fare better with a lower low-density lipoprotein cholesterol (LDL-C) target, as reducing LDL-C levels even below the 90–110 mg/dL target range at <70 mg/dL confers superior protection against the risk of subsequent stroke, according to data from the Treat Stroke to Target trial.
Early dabigatran administration does not contribute to an excess risk of haemorrhagic transformation (HT) as compared with aspirin in patients with acute minor noncardioembolic ischaemic stroke/transient ischaemic attack, according to the results of the phase II DATAS II* study.
Prompt treatment with tranexamic acid may reduce intracerebral haemorrhage (ICH) growth in patients with ongoing bleeding, though the timing of treatment appears to be key to improved outcomes, according to a study presented at ISC 2020.