Treatment Guideline Chart

Infections caused by Candida sp that is associated w/ candidemia & metastatic organ involvement.

Most common pathogens of invasive candidiasis are Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei

Early initiation of antifungal therapy w/ adequate source control is essential in the management of invasive candidiasis.

Invasive Candidiasis References

  1. Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 Mar;48(5):503-535. PMID: 19191635
  2. Dismukes WE. Introduction to antifungal drugs. Apr 20, 2000. Clin Infect Dis. 2000 Apr;30(4):653-657. PMID: 10770726
  3. Edwards JE. Candida Species. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases. 6th ed. Philadelphia: Elsevier Churchill Livingstone, Inc; 2005.
  4. Ministry of Health Malaysia. National antibiotic guideline 2014, 2nd edition. Pharmaceutical Services Divisions, Ministry of Health Malaysia. Dec 2014. Accessed 16 Jul 2015.
  5. Taplitz RA, Kennedy EB, Bow EJ, et al. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA Clinical Practice Guideline update. J Clin Oncol. 2018 Oct;36(30):3043-3054. doi: 10.1200/JCO.18.00374. Accessed 26 Jul 2019. PMID: 30179565
  6. Asiedu DK. Invasive candidiasis. In: Ferri's Clinical Advisor 2021. Philadelphia: Elsevier; 2021. 293-295. Accessed 20 Apr 2021:293-295.
  7. ClinicalKey. Clinical overview: candidiasis. ClinicalKey. Dec 2020.
  8. Durand, ML, Kauffman, CA. Epidemiology, clinical manifestations & diagnosis of fungal endophthalmitis. UpToDate. 03 Aug 2020. Accessed 22 Apr 2021.
  9. Kauffman, CA. Clinical manifestations & diagnosis of candidemia & invasive candidiasis in adults. UpToDate. 23 Feb 2021. Accessed 22 Apr 2021.
  10. Kauffman, CA. Management of candidemia & invasive candidiasis in adults. UpToDate. 03 Feb 2021. Accessed 22 Apr 2021.
  11. Kauffman, CA. Overview of candida infections. UpToDate. 31 May 2019. Accessed 22 Apr 2021.
  12. Onate JM, Rivas P, Pallares C, et al. Colombian consensus on the diagnosis, treatment, & prevention of Candida Spp. disease in children and adults. Infectio. 2018 Sep;23(3):271-304.
  13. Aslam S, Rotstein C; AST Infectious Disease Community of Practice. Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019 Sep(9):e13623. doi: 10.1111/ctr.13623. PMID: 31155770
  14. Center for Disease Control and Prevention. Fungal diseases: Information for healthcare professionals about invasive candidiasis. CDC. Apr 2019.
  15. Cornely OA, Bassetti M, Calandra T, et al. ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18(7):19-37. PMID: 23137135
  16. Kauffman CA. Candidiasis. In: In: Goldman L, Schafer AI, eds. Goldman’s Cecil Medicine. 25th edition. Philadelphia, PA: Elsevier Saunders; 2016.
  17. Martin-Loeches I, Antonelli M, Cuenca-Estrella M, et al. ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients. Intensive Care Med. 2019 Jun;45(6):789-805. doi: 10.1007/s00134-019-05599-w. PMID: 30911804
  18. Pappas PG, Kauffman CA, Andes CR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America (IDSA). Clin Infect Dis. 2016 Feb;62(4):e1-50. doi: 10.1093/cid/civ933. PMID: 26679628
  19. Pappas PG, Lionakis MS, Arendrup MC, et al. Invasive candidiasis. Nat Rev Dis Primers. 2018 May;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
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