intrahepatic%20cholestasis
INTRAHEPATIC CHOLESTASIS
Cholestasis is bile formation and/or bile flow impairment that manifests as fatigue, pruritus and jaundice.
It can be classified into intrahepatic or extrahepatic cholestasis.
Extrahepatic cholestasis develops from mechanical blockage in the duct system or hepatocellular defects.
Intrahepatic cholestasis may be due to functional defects hepatocellularly or from obstructive lesions of the intrahepatic biliary tract distal from the bile canaliculi.

Surgical Intervention

Magnetic Resonance Cholangiopancreatography (MRCP)

  • Safer (as it is non-invasive) option to study and find out more about the status of the biliary tree

Endoscopic Retrograde Cholangiopancreatography (ERCP)

  • Gold standard in visualizing biliary tract and treating extrahepatic biliary obstruction but it is associated with complications such as pancreatitis and sepsis
    • Thus, when extrahepatic obstruction is considered and the need for endoscopic intervention is unclear, MRCP or EUS should be performed
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