intrahepatic%20cholestasis
INTRAHEPATIC CHOLESTASIS
Treatment Guideline Chart
Cholestasis is bile formation and/or bile flow impairment that manifests as fatigue, pruritus and jaundice.
It can be classified into intrahepatic or extrahepatic cholestasis.
Extrahepatic cholestasis develops from mechanical blockage in the duct system or hepatocellular defects.
Intrahepatic cholestasis may be due to functional defects hepatocellularly or from obstructive lesions of the intrahepatic biliary tract distal from the bile canaliculi.

Intrahepatic Cholestasis References

  1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol. 2009 Aug;51(2):237-267. doi: 10.1016/j.jhep.2009.04.009. PMID: 19501929
  2. Ahmed KT, Almashhrawi AA, Rahman RN, et al. Liver diseases in pregnancy: diseases unique to pregnancy. World J Gastroenterol. 2013 Nov;19(43):7639-7646. http://www.ncbi.nlm.nih.gov. Accessed 20 Jan 2015. PMID: PMC3837262
  3. Chapman R, Fevery J, Kalloo A, et al. American Association for the Study of Liver Diseases (AASLD) practice guidelines: diagnosis and management of primary sclerosing cholangitis. Hepatology. 2010 Feb;1(2):660-678. doi: 10.1002/hep.23294. Accessed 12 Jan 2015. PMID: 20101749
  4. deLemos AS, Pratt DS. Immunoglobulin G4-associated cholangitis: the next great masquerader. Gastroenterol Hepatol. 2013 Apr;9(4):255-256. http://www.ncbi.nlm.nih.gov. Accessed 20 Jan 2015. PMID: PMC3977647
  5. Jungst C, Berg T, Cheng J, et al. Intrahepatic cholestasis in common liver diseases. Eur J Clin Invest. 2013 Oct;43(10):1069-1083. doi: 10.1111/eci.12128. Accessed 20 Jan 2015. PMID: 23927644
  6. Royal College of Obstetricians and Gynaecologists. Obstetric cholestasis. London (UK): RCOG Green-top Guideline. 2011;43. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_43.pdf. Accessed 12 Jan 2015
  7. Rull G. Cholestasis. Patient.co.uk. http://www.patient.co.uk. Aug 2011. Accessed 17 Dec 2014.
  8. Rull G. Obstetric cholestasis. Patient.co.uk. http://www.patient.co.uk. Aug 2011. Accessed 17 Dec 2014.
  9. Tran TT, Ahn J, Reau NS. American College of Gastroenterology (ACG) clinical guideline: liver disease and pregnancy. Am J Gastroenterol. 2016 Feb;111(2):176-194. doi: 10.1038/ajg.2015.430. Accessed 24 Oct 2016. PMID: 26832651
  10. Aabakken L, Karlsen TH, Albert J, et al. Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. Endoscopy. 2017 Jun;49(6):588-608. doi: 10.1055/s-0043-107029. PMID: 28420030
  11. European Association for the Study of the Liver. EASL clinical practice guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017 Jul;67(1):145-172. doi: 10.1016/j.jhep.2017.03.022. Accessed 18 Feb 2019. PMID: 28427765
  12. Lindor KD, Lee RH. Intrahepatic cholestasis of pregnancy. UpToDate. https://www.uptodate.com. 08 Dec 2020.
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