Cholestasis is bile formation and/or bile flow impairment that manifests as fatigue, pruritus and jaundice.
It can be classified into intrahepatic or extrahepatic cholestasis.
Extrahepatic cholestasis develops from mechanical blockage in the duct system or hepatocellular defects.
Intrahepatic cholestasis may be due to functional defects hepatocellularly or from obstructive lesions of the intrahepatic biliary tract distal from the bile canaliculi.

Follow Up

  • In patients with PSC, suspect cholangiocarcinoma if with weight loss, worsening cholestasis, elevated serum level of CA 19-9, and/or new or progressive stricture, especially with an enhancing mass lesion 
  • Follow-up in ICP patients should be long enough to ensure a normalization of LFTs, and it is reasonable to check LFTs at 6 weeks
    • If after 6 months there is no improvement, further specialist input will be required 
  • ICP should settle spontaneously following delivery
  • The outcome of drug-induced cholestasis after withdrawal of the drug is generally good and few patients who develop DILI show abnormal liver tests and persistent histological evidence of liver damage at follow-up
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Editor's Recommendations
Most Read Articles
10 Mar 2018
Compared to triple therapy, dual antithrombotic therapy yields reduced bleeding without excess ischaemic and thromboembolic cardiac events in patients with long-term indication to chronic oral anticoagulation following percutaneous coronary intervention, according to a new study.
09 Mar 2018
Exposure to antibiotics during pregnancy, but not in infantile age, appears to carry an increased risk of developing very early onset (VEO) inflammatory bowel disease (IBD) in children, as reported in a study from Sweden.
Pearl Toh, 6 days ago
Listening to upbeat music during an ECG treadmill stress test significantly prolongs exercise time, suggests a pilot study presented at the American College of Cardiology 2018 (ACC.18) Annual Scientific Session in Orlando, Florida, US.
Rachel Soon, 2 days ago

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.