Treatment Guideline Chart

Insomnia can be either having difficulty in initiating sleep, maintaining sleep or experiencing early morning awakening wherein returning to sleep is not easily attained.

These disturbances can cause significant distress and impairment in daytime functioning.

It is the most prevalent sleep disorder in the general population thus accurate diagnosis and effective treatment is necessary.

Insomnia Diagnosis


  • Based on DSM-5 criteria, a diagnosis of insomnia is made if there is a predominant complaint of dissatisfied sleep related to its quantity or quality associated with at least one of the following symptoms:
    • Having trouble with sleep initiation or maintenance; in children, this is manifested as having trouble with sleep without the caregiver’s intervention
    • Interrupted sleep (eg frequent awakenings or early-morning awakening) with difficulty returning to sleep afterwards
  • Also, DSM-5 criteria stated that the sleeping difficulty:
    • Causes distress or impairment in significant areas of functioning (eg social, occupational, educational, academic and/or behavioral)
    • Occurs ≥3 nights per week
    • Last for ≥3 months
    • Occurs even though there is sufficient opportunity for sleep
  • The insomnia is not due to and does not happen during another sleep-wake disorder (eg narcolepsy, a breathing-related sleep disorder, a circadian rhythm sleep-wake disorder or a parasomnia)
  • The symptoms are not caused by effects of substance or medication
  • The disturbance is not associated with coexisting mental disorders and medical conditions
  • May specify insomnia if with non-sleep disorder mental comorbidity, with other medical comorbidity or with other sleep disorder
  • Insomnia may be specified further as:
    • Episodic where symptoms occur for at least a month but less than 3 months
    • Persistent where symptoms occur for ≥3 months
    • Recurrent where ≥2 episodes occur within a span of a year
  • Insomnia lasting for <3 months that meets the criteria for insomnia disorder in regards to frequency, intensity, significant distress and/or impairment should be considered under the other specified insomnia disorder


  • Comprehensive clinical history and physical examination that evaluate sleep and waking function of the patient
    • Sleep history includes sleep habits, sleep environment, work schedules and circadian factors
    • Determine the onset, duration, frequency, severity, course and perpetuating factors
    • Ask about past and current treatments and response of the patient
    • Screen for physical symptoms such as pain, nocturia, shortness of breath, itch, paresthesia, reflux, restlessness or general discomfort, which may disrupt sleep
  • Common medical, psychiatric, and medication/substance-related comorbidities should also be assessed
  • Self-administered questionnaires, sleep log, symptom checklists, psychologic screening tests and interviews with bed partner are some of the instruments that help arrive at the proper diagnosis
    • Ask patient to keep a sleep diary
    • May use questionnaires such as Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI) or Morningness-Eveningness Questionnaire (MEQ)
      • ISI is a self-report tool which measures perceived severity of insomnia and has been shown to be a valid and reliable tool to detect patients with insomnia
      • PSQI may be used to evaluate subjective sleep during the previous month
      • MEQ is for assessment of circadian factor
  • Polysomnography can be used:
    • To evaluate other suspected sleep disorders (ie periodic limb movement disorder)
    • In treatment-resistant insomnia
    • For professional at-risk populations
    • When substantial sleep state misperception is suspected


Short-Term Insomnia Disorder

  • Symptoms are present for <3 months
  • Also referred to as adjustment insomnia or acute insomnia
  • Presence of insomnia associated with an identifiable stressor
  • Sleep disturbance has a relatively short duration, occurring days to weeks, and is expected to resolve when the stressor resolves or when individual is able to adapt
  • Associated with unfamiliar sleep environment, situational stress, acute medical illness or pain, shift work, or caffeine or alcohol use
  • Diagnosis can only be firmly made retrospectively after it has been relieved
  • Usually triggered by: Changes in sleep environment, high arousal states, poor sleep hygiene or short-term circadian rhythm disorders including particularly by jet lag and rotating shift work

Chronic Insomnia Disorder

  • Insomnia persisting for at least 3 months with a frequency of at least 3 times per week
  • Consists of the former terms primary insomnia, secondary insomnia and comorbid insomnia
  • Patients with chronic insomnia should be evaluated for depression

Common Comorbid Medical Disorders and Conditions

  • Neurological
    • Stroke, Parkinson’s disease, dementia, seizure disorders, headache disorders, traumatic brain injury, chronic pain disorders, peripheral neuropathy, neuromuscular disorders
  • Cardiovascular
    • Angina, congestive heart failure
  • Pulmonary/Respiratory
    • Chronic obstructive pulmonary disease (COPD), emphysema, asthma, laryngospasm
  • Gastrointestinal
    • Reflux, peptic ulcer disease, cholelithiasis, colitis, irritable bowel syndrome
  • Genitourinary
    • Incontinence, benign prostatic hypertrophy, interstitial cystitis
  • Endocrine
    • Hyperthyroidism, hypothyroidism, diabetes mellitus
  • Musculoskeletal
    • Rheumatoid arthritis, osteoarthritis, fibromyalgia, Sjogren syndrome, kyphosis
  • Reproductive
    • Pregnancy, menopause, menstrual cycle variations
  • Sleep disorders
    •  Obstructive sleep apnea, central sleep apnea, restless legs syndrome, periodic limb movement disorder, circadian rhythm sleep disorders, parasomnias
      • Screen for obstructive sleep apnea using STOP Bang screening questionnaire: Ask about snoring, tiredness during the day, observed apneic episodes, high blood pressure, body mass index >30 kg/m2, age >50 years, neck circumference >40 cm, and male gender

Common Comorbid Psychiatric Disorders

  • Mood disorders
    • Major depressive disorder, bipolar disorder
  •  Anxiety disorders
    •  Generalized anxiety disorders, panic disorder, posttraumatic stress disorder, obsessive-compulsive disorder
  • Psychotic disorders
    • Schizophrenia, schizoaffective disorder
  •  Amnestic disorders
    • Alzheimer’s disease, other dementias

Common Medications or Substances Contributing to Insomnia

  • Antidepressants
    • Fluoxetine, Paroxetine, Sertraline, Venlafaxine, Duloxetine, monoamine oxidase inhibitors (MAOIs)
  • Stimulants
    • Caffeine, Methylphenidate, amphetamine derivatives, Ephedrine and derivatives, cocaine
  • Decongestants
    • Pseudoephedrine, Phenylephrine, Phenylpropanolamine
  • Narcotic analgesics
    • Oxycodone, Codeine
  • Cardiovascular medications
    • Beta-blockers, alpha-receptor agonists and antagonists, diuretics, lipid-lowering agents
  • Respiratory medications
    • Theophylline, albuterol
  • Alcohol
  • Corticosteroids


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