The rising incidence of infections caused by multidrug-resistant (MDR) gram-negative bacteria has become a serious health threat and a major challenge for intensivists. Against a backdrop of high patient mortality and risk factors for infection in intensive care units (ICU), early adequate therapy is of paramount importance. At a recent Pfizer-sponsored symposium, Dr Asok Kurup, Infectious Disease Physician, Singapore presented the implications of MDR gram-negative infections in critically ill patients in Asia, while Dr Kenneth Chan, Respiratory Physician and Intensivist, Singapore highlighted the role of ceftazidime-avibactam (Zavicefta) and shared published real-world data on ceftazidime-avibactam.
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.
As the COVID-19 pandemic continues to spread around the globe, comparison is often drawn to influenza, another contagious respiratory-borne disease. Recently, Dr Azureen Azmel, a consultant infectious disease physician at Hospital Tengku Ampuan Rahimah (HTAR), and Dr Leong Chee Loon, a consultant infectious disease physician with Hospital Kuala Lumpur (HKL), came together to discuss about the importance of annual influenza vaccination during the current COVID-19 pandemic.
Influenza or influenza-like illness (ILI) is defined as an acute respiratory infectionwith measured fever ≥38°C and cough with an onset within the last 10 days.1 In aninterview with Dr Gogillan Sevaratnam, an occupational health physician from theOccupational Safety and Health Unit, Hospital Kuala Lumpur (HKL), he spoke onthe importance of vaccination in the prevention of influenza, and how healthcareworkers (HCWs) are a priority target group for vaccination.
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.