Persistent pulmonary hypertension of the newborn occurs more frequently in Asian than in western settings, according to a study. Risk factors implicated in mortality include prematurity, congenital diaphragmatic hernia/lung hypoplasia, high frequency oscillation ventilation and inotropic agents.
Resistance of Helicobacter pylori to common antimicrobials is at an alarming level globally, with almost all WHO regions showing at least 15 percent resistance to clarithromycin, metronidazole and levofloxacin, a recent study has found.
Cefiderocol demonstrated noninferiority to imipenem-cilastatin in patients with complicated urinary tract infections (UTIs) and multidrug-resistant Gram-negative infections, according to results of a phase II trial.
Frailty does not impair the efficacy of influenza vaccination in elderly adults, according to a recent Singapore study, which showed that similar degrees of seroprotection and vaccination-induced humoral immune responses were achieved across the different categories of frailty.
The patient profiles of individuals diagnosed with hepatocellular carcinoma (HCC) vary depending on whether the cause of HCC is hepatitis B virus (HBV) infection or cryptogenic, a Singapore study found.
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.
Shortening the 10-day course of intravenous antibiotic therapy by at least 2 days in the management of infants with uncomplicated, late-onset group B streptococcus (GBS) bacteraemia appears to be effective with low rates of disease recurrence and treatment failure, according to a study.
Among patients with culture-negative nosocomial pneumonia, de-escalation of antimethicillin-resistant Staphylococcus aureus therapy is associated with a shorter hospital stay and lower incidence of acute kidney injury (AKI), a study suggests. De-escalation does not alter 28-day mortality.
Intravenous cefiderocol thrice daily is noninferior to imipenem-cilastatin for treating complicated urinary tract infection (UTI) patients with multidrug-resistant, Gram-negative infections, according to a recent study.
In patients with genotype 3 hepatitis C virus (HCV) infection and decompensated cirrhosis, the rate of achieving sustained virologic response 12 weeks after treatment (SVR12) is high with treatment regimens consisting of sofosbuvir and velpatasvir with or without ribavirin, according to the results of a phase II trial. However, the rate appears to be lower in the subgroup of patients with baseline resistance-associated substitutions in nonstructural protein 5A.
In infants with early-life acute respiratory infection (ARI) with respiratory syncytial virus (RSV), elevated nasopharyngeal Lactobacillus levels protect against wheezing illnesses at 2 years of age, a recent study has found.