In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.
Individuals with major depressive disorder (MDD) have lower odds of testing seropositive for measles despite previous immunization, according to a study. This suggests that MDD may increase susceptibility to the infection due to impaired maintenance of vaccine-related protection against measles.
Antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.
Prophylaxis for respiratory syncytial virus (RSV) infection in healthy preterm infants reduced their risk of parent-reported (but not physician-diagnosed) asthma at age 6 years, with no apparent effect on lung function, according to follow-up results of the MAKI* study.
Meropenem-vaborbactam may be effective in improving signs and symptoms and eradicating causative pathogens in patients with complicated urinary tract infections (UTIs), the phase III TANGO I* trial showed.
Mother-to-child transmission (MTCT) of the hepatitis B virus (HBV) from carrier mothers to their infants may be preventable if antiviral therapy is initiated from the third trimester of pregnancy, according to a study presented at RCOG 2018.
Less than half of patients in this study have met the criteria for severe Clostridium difficile infection (CDI). Furthermore, almost half of providers for those with severe infection and longer duration of antibiotic therapy are less likely to adhere to the institutional guideline.
New drug applications approved by US FDA as of 16 - 31 March 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvalsmay have occurred since the original approval date.
A US study suggests that expanding HIV screening to reduce undiagnosed infections and increasing access to care and treatment to achieve viral suppression are important to lessen HIV transmission. It is also imperative that prevention methods, such as condoms and pre-exposure prophylaxis, be easily accessed, particularly among young men who have sex with men (MSM) and MSM of colour.