Dupilumab significantly improves all disease components of severe, uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) — a primarily type 2 inflammatory condition — compared with placebo when both are added to standard of care. Furthermore, the treatment benefit extends to even patients with comorbid nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NSAID-ERD), according to a pooled analysis of the LIBERTY NP SINUS-24 and -52* trials presented at ERS 2019.
The use of tumour necrosis factor-α (TNFα) inhibitors was not associated with an increased risk of infection in children with inflammatory bowel disease (IBD), a contrast to previous findings in adult IBD, a study from Denmark showed.
The combination of sofosbuvir and velpatasvir is safe and effective for the treatment of hepatitis C virus (HCV) in patients with end-stage renal disease (ESRD) undergoing haemodialysis, a study has shown.
The combination of sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is safe and effective as rescue therapy for hepatitis C patients in whom prior direct-acting antivirals (DAAs) had failed, a new study has found.
In children admitted for orbital complications of acute rhinosinusitis (ARS), the most important causes of medical treatment failure are older age and stage II/III orbital complications at presentation, a recent study has shown.
Clostridium difficile (CD) infection remains high in patients with acute myeloid leukaemia (AML) or myelodysplasia syndrome (MDS) undergoing allogeneic haematopoietic stem cell transplantation (alloHCT), a recent study has shown. Moreover, patients with CD infection appear to have a significantly lower overall survival.
Age and blood biomarkers such as aspartate aminotransferase (AST), alkaline phosphatase (ALP) and the hepatitis B surface antigen (HBsAg) predict mortality risk in patients with advanced schistosomiasis 2 years after discharge, a recent study has found.
Healthcare personnel (HCP) who use medical masks when in contact with patients with respiratory illness are no more likely to acquire influenza or other viral respiratory illnesses than HCPs who use N95 respirators, according to the ResPECT* study.
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
Final overall survival (OS) results from the double-blind phase III FLAURA study reinforce osimertinib as the standard frontline treatment for epidermal growth factor receptor-mutated (EGFRm) non–small cell lung cancer (NSCLC), say leading oncologists at ESMO 2019.
Babies born to mothers exposed to high levels of bisphenol A during pregnancy are at a greater risk of wheezing and poor lung function, according to a new study presented at the recently concluded International Congress of the European Respiratory Society (ERS 2019).