New drug applications approved by US FDA as of 1 - 15 July 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Hepatitis C virus (HCV) treatment may benefit patients with HCV-related hepatocellular carcinoma (HCC) who respond to the initial HCC palliative treatment, suggest the results of a study, adding, however, that treating HCV in HCC patient undergoing noncurative HCC treatment remains debatable.
Respiratory infections, particularly influenza, may increase the risk of treatment failure in children with asthma who present to emergency departments (EDs) with exacerbations, a secondary analysis of the DOORWAY* study revealed.
Higher doses of rifampin result in more rapid sputum sterilization and similar toxicity, a study has shown. These findings support the investigation of increased rifampin doses to shorten tuberculosis treatment.
Continuous low-dose antibiotic prophylaxis safely and effectively reduces the frequency of urinary tract infections (UTI) in adult users of clean intermittent self-catheterization (CISC), according to a recent study.
The use of ethanol lock therapy did not reduce treatment failure of central line-associated bloodstream infections (CLABSIs) in patients with cancer or haematological disorders, but was associated with an increased risk of catheter occlusion, a recent study found.
A large number of patients who present at outpatient clinics with symptoms of acute respiratory infections (ARIs) during influenza seasons are prescribed antibiotics despite not needing them, a finding that highlights the overuse of antibiotics in ARIs, a recent study showed.
Influenza is a highly contagious viral disease, which is primarily spread through water droplets containing strains of the virus. Dr Leong Chee Loon shares his insights into the management of influenza in Malaysia, highlighting the importance of improving vaccination coverage in populations at high-risk of influenza-related complications, such as elderly patients and healthcare practitioners.
The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.
The addition of low oxygen levels measured by pulse oximetry to the three signs delineated in the current diagnostic model for pneumonia in primary care setting derived by van Vugt, which include fever, tachycardia, and crackly breath sounds on auscultation, can add value to diagnostic precision and help general practitioners (GPs) differentiate pneumonia from less serious infections, a study suggests.
Ceftazidime-avibactam appears to offer a reasonable alternative to colistin in the treatment of Klebsiella pneumoniae carbapenemase (KPC)-producing carbapenem-resistant Enterobacteriaceae (CRE) infections, according to a study.