A once-daily oral dose of sofosbuvir and velpatasvir for 12 weeks leads to sustained virological response (SVR) in a majority of patients with chronic hepatitis C virus (HCV) infection, according to an Asian study. However, the efficacy of this regimen may be reduced in patients with HCV genotype 3b with cirrhosis.
Echinocandins are noninferior to amphotericin B (AmB) formulations in the treatment of invasive candidiasis (IC) in children, with fewer discontinuations than in comparator arm, a recent meta-analysis has shown.
There is a significantly lower rate of recurrence in cases of hospital-acquired Clostridium difficile infection (HA-CDI), a population that is more likely to be immunocompromised, compared with community-acquired (CA)-CDI, according to a new study. Additionally, treatment with faecal microbiota transplant is successful in patients with recurrent CDI.
The presence of frailty is associated with an elevated risk of subsequent incidence of cardiovascular disease, diabetes and bone disease among adults infected with HIV, a study has shown. Moreover, an increase in frailty over 48 weeks is tied to a greater risk of death.
The non-steroidal phosphodiesterase-4 inhibitor crisaborole may reduce lesions in patients with mild-to-moderate atopic dermatitis (AD), according to an intrapatient randomized study presented at the Inflammatory Skin Disease Summit (ISDS) 2018.
The application of mupirocin to multiple body sites of infants appears to be safe and effective for eradicating Staphylococcus aureus carriage in the neonatal intensive care unit setting, a study has found. However, recolonization occurs after 2–3 weeks in a number of infants who remain hospitalized.
Elderly individuals with a Clostridium difficile (C. difficile) infection have a higher risk of 30-day mortality and admission to long- or short-term facilities compared with their counterparts without C. difficile infection, a recent study showed.
A broad range of peripheral infections, including those of the central nervous system, appears to be associated with a heightened risk of developing epilepsy, potentially due to inflammatory processes affecting the brain, according to a study.
Multidrug-resistant organisms (MDROs) are frequently defined as bacteria with resistance to three or more classes of antimicrobials. Common examples include methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamases (ESBL)–producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant Enterococci (VRE). The challenges of managing these infections are illustrated in the following two cases.
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.