Elite HIV controllers—those who can control viral replication without medications—have fewer proviral sequences, a recent study has found. These viral genomes appear to be more concentrated in inaccessible and transcriptionally repressed areas of the genome.
Recycling tenofovir after failure of first-line treatment vs switching to second-line zidovudine is associated with better care retention, adherence, and viral load suppression in HIV patients, especially when combined with atazanavir boosted with ritonavir, a new study presented at AIDS 2020 Virtual has shown.
A new dengue vaccine candidate, TAK-003, has demonstrated the persistence of neutralizing antibodies in participants who were inoculated with the vaccine up to 3 years post-vaccination, reports a recent study.
While generally a self-limiting condition, hand, foot, and mouth disease (HFMD) can spread very quickly, particularly among children attending childcare centres. Dr Chan Si Min, Head and Senior Consultant at the Division of Paediatric Infectious Diseases, National University Hospital, Singapore, talks to Roshini Claire Anthony about the complications and management of HFMD.
A study with limited case data reveals a shorter duration of viral shedding of SARS-CoV-2, the causative agent of the novel coronavirus disease (COVID-19), through the upper respiratory tract in children compared with adults.
HIV-1 RNA viral suppression is comparable between tenofovir alafenamide (TAF)/emtricitabine (FTC) + dolutegravir (DTG), tenofovir disoproxil fumarate (TDF)/FTC + DTG, and TDF/FTC/efavirenz (EFV) regimens, according to updated results of the ADVANCE trial.
Hypertensive patients are twice more likely to die from COVID-19 — particularly if they are not treated with antihypertensive medications — than people without hypertension, a large retrospective study has shown.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.