Treatment with luspatercept, a first-in-class erythroid maturation agent, help achieves red blood cell transfusion independence (RBC-TI) in patients with anaemia who had low-risk myelodysplastic syndrome (MDS) with ring sideroblasts (RS), according to results of the MEDALIST* trial presented at ASH 2018.
In the era of Highly Active Antiretroviral Therapy (HAART), majority of the malignancies in AIDS patients are non-AIDS-defining cancers (NADC), according to an India study presented at the recently concluded European Society for Medical Oncology Asia 2018 Congress (ESMO Asia 2018).
At the recent 4th National Aids Conference, Dr Charles Hicks, Senior Global Medical Director, ViiV Healthcare, US, spoke about the evolution of HIV care and how future advancements will impact the lives of persons living with HIV. Hicks, who is only recently joined ViiV Healthcare, said the cure for HIV is still likely far in the future. In the meantime, the only option is antiretroviral therapy (ART). However, despite the absence of a cure, the outlook for patients living with HIV has improved by leaps and bounds since the first antiretroviral zidovudine (AZT) was released.
Treatment with the combination of the DAAs* glecaprevir and pibrentasvir led to sustained virological response (SVR) in a majority of patients with chronic hepatitis C virus (HCV) infection genotype 5 or 6, according to the phase IIIB ENDURANCE-5,6** trial.
Relying on urinary symptoms alone may lead to an inaccurate diagnosis of culture-positive urinary tract infection, according to a recent Singapore study, which also reports that concurrent urine microscopy may improve diagnostic accuracy.
Individuals hospitalized with pneumonia have an elevated risk of developing major adverse cardiovascular events (MACE), with a greater risk among those with bacterial compared with viral pneumonia, according to a recent study presented at AHA 2018.
Cefiderocol demonstrated noninferiority to imipenem-cilastatin in patients with complicated urinary tract infections (UTIs) and multidrug-resistant Gram-negative infections, according to results of a phase II trial.
Frailty does not impair the efficacy of influenza vaccination in elderly adults, according to a recent Singapore study, which showed that similar degrees of seroprotection and vaccination-induced humoral immune responses were achieved across the different categories of frailty.
The patient profiles of individuals diagnosed with hepatocellular carcinoma (HCC) vary depending on whether the cause of HCC is hepatitis B virus (HBV) infection or cryptogenic, a Singapore study found.
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.