Using sofosbuvir-based direct antiviral agents (DAAs) may accelerate the decline of estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C virus (HCV) infections, reports a new study.
SER-109, an investigational microbiome drug consisting of a consortium of bacterial spores from healthy donors to prevent recurrent Clostridioides difficile infection (CDI), has shown a favourable safety profile in a phase II trial. Early engraftment of SER-109 dose-species helps reduce the risk of recurrence, although engraftment kinetics suggests a higher dosing to increase efficacy.
Adjuvanted FLU-v, a broad-spectrum influenza vaccine that induces antibodies and cell-mediate immunity, has demonstrated immunogenicity in a phase IIb trial, warranting phase III development to explore its safety and efficacy.
Patients with coronavirus disease 2019 (COVID-19) pneumonia appear to exhibit potential mild pancreatic injury patterns, which may be linked to direct viral involvement of the pancreas or to secondary enzyme abnormalities in the setting of severe illness without extensive pancreatic injury, as reported in a study.
In chronic hepatitis C (CHC) patients, achieving sustained virological response (SVR) after therapy with pegylated interferon with ribavirin (PR) does not reduce the risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), a recent study has shown.
There appears to be no evidence of the SARS-CoV-2 virus in the semen of patients recovering from COVID-19 a month after diagnosis, according to a study, suggesting that the virus is unlikely to gain entry into testicular cells through an ACE2/TMPRSS2-mediated mechanism.
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.
In the fight against the coronavirus disease 2019 (COVID-19) pandemic, healthcare workers experience a range of physical symptoms, which are strongly related to psychological distress, according to a study, suggesting a bidirectional relationship between physical symptoms and psychological outcomes.