One in four cases of Gram-negative bacilli (GNB) bloodstream infection (BSI) is multidrug-resistant, a new study has found. Risk factors for multidrug-resistant GNB BSI in children’s hospitals include cancer chemotherapy and older age. Multidrug resistance, however, does not seem to increase the rate of all-cause mortality.
Hearts and lungs from donors with hepatitis C viraemia may be safely transplanted to a recipient, according to a recent study. The strategy to prevent the development of hepatitis C virus (HCV) infection is to administer an antiviral regimen within a few hours after the surgery.
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Various biologic medications used prior to total knee or hip arthroplasty demonstrate similar risks for hospitalized infection, prosthetic joint infection (PJI) and readmission after surgery, reports a study. In contrast, glucocorticoids, particularly with dosages >10 mg/d, yield a greater risk for adverse outcomes.
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
A two-step algorithm that incorporates the liver stiffness measurement hepatocellular carcinoma (LSM-HCC) score and enhanced liver fibrosis (ELF) score appears to improve the accuracy of predicting HCC in chronic hepatitis B (CHB) patients after antiviral treatment, according to a study from Hong Kong.
Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.