Individuals with obesity are at an elevated risk of developing infections, particularly that of the skin in both men and women, and those of the gastrointestinal and urinary tracts and sepsis in women only, according to a study.
The PRoFeSs score―which includes the Charlson score, as well as levels of day 3 lactate, day 1 and day 3 procalcitonin, day 3 D-dimer, and day 1 brain-type natriuretic peptide―can identify severe community-acquired pneumonia patients at high risk of poor outcomes 5 days after ICU admission, a recent study has found.
An 8- or 12-week regimen of glecaprevir plus pibrentasvir appears to be safe and effective in the treatment of genotype 2 hepatitis C virus (HCV) infection in patients undergoing haemodialysis, as reported in a recent Japanese cohort study.
Bloodstream infections are common among patients with epidermal necrolysis and are mostly caused by Staphylococcus aureus and Pseudomonas aeruginosa, a recent study has found. Skin cultures may help predict such infections.
Hepatitis C virus (HCV) transmission from infected children to other relatives happens, and the only documented way of transmission either directly or indirectly is through parenteral route, a recent study has found.
An investigational bivalent Clostridium difficile vaccine that contains equal dosages of genetically and chemically detoxified toxins A and B has a tolerable safety profile and is immunogenic in healthy older adults, according to the results of a phase II trial.
Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.
Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng,
10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.