Combination therapy with the NS5A inhibitor ledipasvir and NS5B inhibitor sofosbuvir appears to be highly effective in the management of chronic hepatitis C virus genotype 1 infection, yielding a sustained virologic response of >90 percent without increasing the incidence of serious adverse events, according to data from a real-world Japanese cohort.
Use of rifaximin as a follow-on medication after successful treatment of Clostridium difficile infection in frail elderly patients appears to halve recurrence rate, according to the results of the RAPID* trial. However, the results do not rule out the possibility of no effect.
Critically ill children harbouring Stenotrophomonas maltophilia in the intensive care unit (ICU) may benefit from the combination treatment of trimethoprim and sulfamethoxazole, ciprofloxacin, and minocycline, suggests a recent study.
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.
Male gender, motor complete injury, presence of chest trauma and delayed intubation are risk factors for elevated pneumonia risk in critically ill spinal cord injured patients, reports a recent study, which enables the future synthesis of a pneumonia prediction tool for use in the acute postinjury period.
Iron deficiency is associated with a reduced risk of developing malaria infection, as shown in a cohort study of African children. As such, improving iron status may predispose this population to infection.
Due to varying analyses and reporting methods, fever rates in studies substantially differ. As such, there is a need for standardized fever reporting to allow comparisons between studies, according to a recent investigation.
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.
A US study suggests that expanding HIV screening to reduce undiagnosed infections and increasing access to care and treatment to achieve viral suppression are important to lessen HIV transmission. It is also imperative that prevention methods, such as condoms and pre-exposure prophylaxis, be easily accessed, particularly among young men who have sex with men (MSM) and MSM of colour.