Infectious Diseases

Top Medical News
Roshini Claire Anthony, 14 hours ago

A once-weekly prophylactic dose of azithromycin does not improve lung function in children with HIV-associated chronic lung disease (HCLD), according to results of the BREATHE* trial. However, azithromycin was associated with a reduction in acute respiratory exacerbations (AREs).

Jairia Dela Cruz, 18 hours ago
In the treatment of patients with community-acquired bacterial pneumonia (CABP), omadacycline is as effective as moxifloxacin at inducing response in patients with Pneumonia Patient Outcomes Research Team (PORT) risk class III and IV, according to data from the phase III OPTIC* trial.
Christina Lau, 22 hours ago

Altered gut microbiota composition in patients with coronavirus disease 2019 (COVID-19) compared with controls is linked to COVID-19 severity and may contribute to persistent symptoms after viral clearance, according to a study by the Chinese University of Hong Kong (CUHK).

Tristan Manalac, 23 hours ago
Recent research has shown that the population of CD8+ T cells targeting SARS-CoV-2 are very diverse. Patients who recover from a severe episode of the novel coronavirus disease (COVID-19) tend to have robust T cell memory responses, as opposed to a more exhausted, restrained repertoire of cells found in those who only developed mild disease.
Roshini Claire Anthony, Yesterday

The combination of baricitinib and remdesivir improved recovery time and clinical status of patients with COVID-19 compared with remdesivir monotherapy, results of the ACTT*-2 study showed.

Elvira Manzano, Yesterday
The approval of the first COVID-19 vaccine came at a breakneck speed in December. Inoculation started in the US, liberating pent-up hopes that virus-ravaged states could get past the pandemic that has killed over 1.5 million people across continents.
Elvira Manzano, Yesterday
Patients with diabetes and hypertension are at an increased risk for neurologic complications from COVID-19, and this makes an already bad prognosis into worse, reports an expert at RSNA 2020.
Special Reports
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Dr. Asok Kurup, Dr. Kenneth Chan, 07 Dec 2020
The rising incidence of infections caused by multidrug-resistant (MDR) gram-negative bacteria has become a serious health threat and a major challenge for intensivists. Against a backdrop of high patient mortality and risk factors for infection in intensive care units (ICU), early adequate therapy is of paramount importance. At a recent Pfizer-sponsored symposium, Dr Asok Kurup, Infectious Disease Physician, Singapore presented the implications of MDR gram-negative infections in critically ill patients in Asia, while Dr Kenneth Chan, Respiratory Physician and Intensivist, Singapore highlighted the role of ceftazidime-avibactam (Zavicefta) and shared published real-world data on ceftazidime-avibactam. 
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.
01 Nov 2020
As the COVID-19 pandemic continues to spread around the globe, comparison is often drawn to influenza, another contagious respiratory-borne disease. Recently, Dr Azureen Azmel, a consultant infectious disease physician at Hospital Tengku Ampuan Rahimah (HTAR), and Dr Leong Chee Loon, a consultant infectious disease physician with Hospital Kuala Lumpur (HKL), came together to discuss about the importance of annual influenza vaccination during the current COVID-19 pandemic.
16 Sep 2020
XOFLUZA – Baloxavir marboxil 20 mg and 40 mg FC tab
22 Jun 2020
Influenza or influenza-like illness (ILI) is defined as an acute respiratory infectionwith measured fever ≥38°C and cough with an onset within the last 10 days.1 In aninterview with Dr Gogillan Sevaratnam, an occupational health physician from theOccupational Safety and Health Unit, Hospital Kuala Lumpur (HKL), he spoke onthe importance of vaccination in the prevention of influenza, and how healthcareworkers (HCWs) are a priority target group for vaccination.
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Conference Reports
Roshini Claire Anthony, 17 Dec 2020

Switching to a telemedicine-only strategy from face-to-face visits does not affect asthma control in children. Moreover, the strategy may actually increase show rates, according to a study presented at the recent ACAAI 2020 meeting.

Elvira Manzano, 12 Dec 2020
Having asthma or allergy does not make COVID-19 severe, a new study presented at ACAAI 2020 has shown.
Roshini Claire Anthony, 08 Dec 2020

The elevations in liver enzymes that occur in patients with COVID-19 may be due to other conditions and not as a direct result of COVID-19, according to a poster presented at the AASLD 2020 Liver Meeting.

Roshini Claire Anthony, 04 Dec 2020

Adjunctive daptomycin in addition to standard-of-care (SoC) treatment does not reduce the duration of bloodstream infections caused by methicillin-susceptible Staphylococcus aureus (MSSA), according to the DASH* study presented at ID Week 2020.

Roshini Claire Anthony, 02 Dec 2020

People with HIV (PWH) who are hospitalized due to COVID-19 may have an increased mortality risk, according to a study from the UK.

Elvira Manzano, 30 Nov 2020
HIV patients hospitalized for COVID-19 are at a higher risk of mortality than those hospitalized without HIV in a new study reported at HIV Glasgow 2020.
Roshini Claire Anthony, 25 Nov 2020

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

CME Modules
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