hypothyroidism
HYPOTHYROIDISM
Hypothyroidism is a common endocrine disorder where in the thyroid does not make enough thyroid hormone.
Subclinical/mild hypothyroidism refers to the state of slightly increased serum TSH with normal serum FT4 in patients who are usually asymptomatic.
Most common cause of primary hypothyroidism is autoimmune thyroiditis or Hashimoto's disease.
Levothyroxine is the first-line agent for treatment of hypothyroidism.

Definition

Defined as the inability of the thyroid gland  to make enough thyroid hormones

Signs and Symptoms

  • Cold intolerance
  • Wt gain
  • Dry skin
  • Periorbital puffiness
  • Hair loss
  • Voice change; hoarseness
  • Slow speech
  • Weakness, fatigue
  • Constipation
  • Menorrhagia
  • Hyperlipidemia
  • Depression
  • Poor memory
  • Myxedema (non-pitting edema)
  • Pallor
  • Goiter
  • Alopecia
  • Myalgia
  • Effusions
  • Delayed relaxation of deep tendon reflexes
  • Bradycardia
  • Anemia
  • Galactorrhea

Risk Factors

Special Population w/ Higher Risk of Developing Hypothyroidism

  • Postpartum women
  • Individuals w/ a family history of autoimmune thyroid disorders
  • Patients w/ previous head & neck or thyroid irradiation
  • Other autoimmune endocrine conditions
    • Type 1 DM, adrenal insufficiency (AI), ovarian failure
  • Other non-endrocrine autoimmune disorders
    • Celiac disease, vitiligo, pernicious anemia, Sjogren’s syndrome, multiple sclerosis
  • Down’s & Turner’s syndrome
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
09 May 2019
Nurses who utilize the pen device take less time preparing and administering insulin compared with those who use the vial and syringe method, reports a recent study.
14 May 2019
Excessive gains in overall and central fat prior to the childbearing period pose an increased risk of developing gestational diabetes mellitus, a study has found.
24 Apr 2019
Severe vitamin D deficiency may be detrimental to diabetic patients, with the condition increasing the risk of diabetic foot ulcer, according to the results of a meta-analysis.
6 days ago
New drug applications approved by US FDA as of 01 - 15 May 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.