hypothyroidism
HYPOTHYROIDISM
Hypothyroidism is a common endocrine disorder where in the thyroid does not make enough thyroid hormone.
Subclinical/mild hypothyroidism refers to the state of slightly increased serum TSH with normal serum FT4 in patients who are usually asymptomatic.
Most common cause of primary hypothyroidism is autoimmune thyroiditis or Hashimoto's disease.
Levothyroxine is the first-line agent for treatment of hypothyroidism.

Definition

Defined as the inability of the thyroid gland  to make enough thyroid hormones

Signs and Symptoms

  • Cold intolerance
  • Weight gain
  • Dry skin
  • Periorbital puffiness
  • Hair loss
  • Voice change; hoarseness
  • Slow speech
  • Weakness, fatigue
  • Constipation
  • Menorrhagia
  • Hyperlipidemia
  • Depression
  • Poor memory
  • Myxedema (non-pitting edema)
  • Pallor
  • Goiter
  • Alopecia
  • Myalgia
  • Effusions
  • Delayed relaxation of deep tendon reflexes
  • Bradycardia
  • Anemia
  • Galactorrhea

Risk Factors

Special Population with Higher Risk of Developing Hypothyroidism

  • Postpartum women
  • Individuals with a family history of autoimmune thyroid disorders
  • Patients with previous head and neck or thyroid irradiation
  • Other autoimmune endocrine conditions
    • Type 1 diabetes mellitus (DM), adrenal insufficiency (AI), ovarian failure
  • Other non-endrocrine autoimmune disorders
    • Celiac disease, vitiligo, pernicious anemia, Sjogren’s syndrome, multiple sclerosis
  • Down’s & Turner’s syndrome
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