hypothyroidism
HYPOTHYROIDISM
Hypothyroidism is a common endocrine disorder where in the thyroid does not make enough thyroid hormone.
Subclinical/mild hypothyroidism refers to the state of slightly increased serum TSH with normal serum FT4 in patients who are usually asymptomatic.
Most common cause of primary hypothyroidism is autoimmune thyroiditis or Hashimoto's disease.
Levothyroxine is the first-line agent for treatment of hypothyroidism.

Hypothyroidism Signs and Symptoms

Definition

Thyroid hormone deficiency due to underactive thyroid that may be secondary to hypothalamic-pituitary disease or primary thyroid disease

Signs and Symptoms

  • Variable signs and symptoms but typical symptoms are fatigue, weight gain, cold intolerance, constipation and dry skin
  • Neurological
    • Weakness
    • Depression
    • Poor memory
    • Delayed relaxation of deep tendon reflexes
  • Head and neck
    • Periorbital puffiness
    • Hair loss/alopecia
    • Voice change; hoarseness
    • Slow speech
  • Gastrointestinal
    • Constipation
  • Cardiovascular
    • Bradycardia
    • Hyperlipidemia
    • Pericardial effusion
  • Others
    • Menorrhagia
    • Myxedema (non-pitting edema)
    • Pallor
    • Goiter
    • Myalgia
    • Anemia
    • Galactorrhea

Risk Factors

Special Population with Higher Risk of Developing Hypothyroidism

  • Postpartum women
  • Infertile individuals
  • Individuals with a family history of autoimmune thyroid disorders
  • Patients with previous head and neck or thyroid irradiation
  • Other autoimmune endocrine conditions
    • Type 1 diabetes mellitus (DM), adrenal insufficiency (AI), ovarian failure
  • Other non-endrocrine autoimmune disorders
    • Celiac disease, vitiligo, pernicious anemia, Sjogren’s syndrome, multiple sclerosis
  • Down’s and Turner’s syndrome
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
30 Aug 2020
Diabetes bears an increased hazard of developing kidney cancer among postmenopausal women, but this association is only limited to those without obesity, a study has shown.
11 Jul 2020
Individuals who eat large amounts of vegetables and fruits, wheat, nuts, and dairy products are better protected against insulin resistance, diabetes mellitus, and excessive abdominal fat as compared with those who consume lots of fast foods, alcoholic beverages, and desserts—a dietary pattern described to promote metabolic abnormalities and disorders, as reported in a study.
22 Aug 2020
A weakened correlation between fructosamine and glycated haemoglobin (HbA1c) levels may be indicative of obesity in type 2 diabetes patients, reports a new study.
29 Aug 2020
Sodium-glucose co-transporters (SGLT) 2 and 1/2 inhibitors help improve glycaemic control in patients with type 1 diabetes (T1D), reports a new meta-analysis.