Hypothyroidism is a common endocrine disorder where in the thyroid does not make enough thyroid hormone.
Subclinical/mild hypothyroidism refers to the state of slightly increased serum TSH with normal serum FT4 in patients who are usually asymptomatic.
Most common cause of primary hypothyroidism is autoimmune thyroiditis or Hashimoto's disease.
Levothyroxine is the first-line agent for treatment of hypothyroidism.

Hypothyroidism References

  1. American Association of Clinical Endocrinologists and the American College of Endocrinology. Medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002 Nov;8(6):457-469. https://www.aace.com/files/hypo_hyper.pdf. PMID: 15260011
  2. Hypothyroidism [patient notes]. Postgrad Med. 2000;107(1)
  3. Cooper DS. Subclinical hypothyroidism. N Engl J Med. 2001 Jul;345(4):260-265. PMID: 11474665
  4. Devdhar M, Ousman YH, Burman KD. Hypothyroidism. Endocrinol Metab Clin North Am. 2007 Sep;36(3):595-615. http://dx.doi.org/10.1016/j.ecl.2007.04.008. PMID: 17673121
  5. Ladenson PW, Singer AP, Alin KB, et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000 Jun;160(11):1573-1575. PMID: 10847249
  6. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease scientific review and guidelines for diagnosis and management. JAMA. 2004 Jan;291(2):228-238. PMID: 14722150
  7. Roberts CGP, Ladenson PW. Hypothyroidism. Lancet. 2004 Mar;363(9411):793-803. PMID: 15016491
  8. Singer PA, Cooper SD, Elliot GL, et al. Treatment guidelines for patients with hyperthyroidism and hypothyroidism. JAMA. 1995 Mar;273(10):808-812. PMID: 7532241
  9. Hypothyroidism. Merck Manual; 2014 May. http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/thyroid_disorders/hypothyroidism.html?qt=hypothyroidism&alt=sh.
  10. Grace K, Davies TF. Hypothyroidism. Comprehensive clinical endocrinology. 3rd ed. London: Mosby; 2002
  11. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  12. Malaysian Endocrine and Metabolic Society. Practice guidelines for thyroid disorders: The Malaysian Consensus. http://www.acadmed.org.my/. 2000.
  13. Ferry RJ, Bauer AJ. Hypothyroidism. eMedicine. http://www.emedicine.com/ped/topic1141.htm. Accessed 01 Jul 2008.
  14. Orlander PR. Hypothyroidism. http://emedicine.medscape.com/article/122393-overview. 2002
  15. Garber JR, Cobin RH, Gharib H,et al; American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012 Nov;18(6):988-1028. PMID: 23246686
  16. Berg AO. Screening for thyroid disease: United States Preventive Services Task Force recommendation statement. Ann Int Med. 2004;140:125-127.
  17. Ross DS. Central hypothyroidism. UpToDate. http://www.uptodate.com. Feb 2018.
  18. Persani L, Brabant G, Dattani M, et al. 2018 European Thyroid Association (ETA) guidelines on the diagnosis and management of central hypothyroidism. Eur Thyroid J. 2018 Oct;7(5):225-237. doi: 10.1159/000491388. PMID: 30374425
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